Association Between Preoperative 25-Hydroxyvitamin D Level and Hospital-Acquired Infections Following Roux-en-Y Gastric Bypass Surgery
JAMA Surg. 2014;149(2):112-118. doi:10.1001/jamasurg.2013.3176
Sadeq A. Quraishi, MD, MHA； Edward A. Bittner, MD, PhD； Livnat Blum, BA；Mathew M. Hutter, MD, MPH； CarlosA. CamargoJr, MD, DrPH
Items in both categories Immunity and Trauma-Surgery are listed here:
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- Orthopaedic surgeries need Vitamin D – many studies
- The effect of vitamin D on different human cells, with emphasis on burns and ICU – April 2018
- Vitamin D might reduce suture infection when time-released from nano-structure suture – Nov 2017
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Immunity category starts with:
see also
Virus category listing hasOverview Influenza and vitamin D
Vitamin D helps both the innate and adaptive immune systems fight COVID-19 – Jan 2022
Vitamin D aids the clearing out of old cells (autophagy) – many studies
600,000 IU of Vitamin D (total) allowed previously weak immune systems to fight off a virus antigen - Nov 2020
Search for treg OR "t-cell" in VitaminDWiki 1440 items as of Jan 2020
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Vitamin D and the Immune System – chapter Aug 2019
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Only the brain is more complex, nothing about Vitamin D
18 titles in VitaminDWiki contained INNATE or ADAPTIVE as of Jan 2023
Increasing publications on vitamin D and Infection
Optimum category starts with
The RDA (600 IU is barely enough for bones of infants.
Need an optimal level for the body to thrive
Example pages
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- Revisiting Vitamin D Guidelines – Holick Oct 2024 has
- Saudi study defines normal Vitamin D level to be 50 to 70 ng (diabetes, etc.) - June 2020
- Need 40 to 60 ng of Vitamin D – 48 scientists call for action – 2015
- Vitamin D RDA of 600 IU is not enough - global RCT meta-analysis March 2019
- Vitamin D sufficiency 10 to 30 ng, optimal 40 to 80 ng (no consensus)– May 2018
- 4 X fewer visits to Dr. after getting high level of vitamin D (Interview with transcript) - Jan 3, 2022
- Vitamin D sufficiency 10 to 30 ng, optimal 40 to 80 ng (no consensus)– May 2018
- Sports benefits from up to 50 ng of Vitamin – meta-analysis - Nov 2012
- Vitamin D of 32 to 60 ng is needed before, during, and after pregnancy – Dec 2012
- Hypothesis by VitaminDWiki – Vitamin D levels are no longer limited by evolution
- VitaminDWiki pages with HIGH-DOSE in title 878 as of Nov 2024
Download the PDF from VitaminDWiki
IMPORTANCE Postoperative hospital-acquired infections (HAIs) may result from disruption of natural barrier sites. Recent studies have linked vitamin D status and barrier site integrity.
OBJECTIVE To investigate the association between preoperative vitamin D status and the risk for HAIs.
DESIGN, SETTING, AND PARTICIPANTS A retrospective analysis was performed using propensity score methods to construct a matched-pairs cohort to reduce baseline differences between patients with 25-hydroxyvitamin D (25[OH]D) levels less than 30 ng/mLvs 30 ng/mL or greater. Multivariable logistic regression analysis was then performed to examine the association between 25(OH)D levels and HAIs while adjusting for additional perioperative factors. Locally weighted scatterplot smoothing was used to depict the relationship between increasing 25(OH)D levels and the risk for HAIs. This study was conducted in a single, teaching hospital in Boston, Massachusetts, and involved 770 gastric bypass surgery patients between January 1, 2007, and December 31,2011.
EXPOSURES Preoperative 25(OH)D levels.
MAIN OUTCOMES AND MEASURES Association between preoperative 25(OH)D levels and the riskfor postoperative HAIs.
RESULTS The riskfor HAIswas3-fold greater (adjusted odds ratio, 3.05; 95% CI, 1.34-6.94) in patients with 25(OH)D levels less than 30 ng/mL vs 30 ng/mL or greater. Further adjustment for additional perioperative factors did not materially change this association. Locally weighted scatterplot smoothing analysis depicted a near inverse linear relationship between vitamin D status and the risk for HAIs for 25(OH)D levels around 30 ng/mL.
CONCLUSIONS AND RELEVANCE In our patient cohort, a significant inverse association was observed between preoperative 25(OH)D levels and the risk for HAIs. These results suggest that preoperative 25(OH)D levels may be a modifiable risk factor for postoperative nosocomial infections. Prospective studies must determine whether there is a potential benefit to preoperative optimization of vitamin D status.
Study was cited by 67 publications as of Nov 2022
- The Association of Serum Vitamin D Concentration with Serious Complications After Noncardiac Surgery- 2014 PDF
20 X less likely if very high vitamin D
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| 15677 | The Association of Serum Vitamin D Concentration with Serious Complications After Noncardiac Surgery.pdf | admin 30 May, 2021 | 218.06 Kb | 340 | |
| 15676 | Infection 50 ng.jpg | admin 30 May, 2021 | 28.17 Kb | 4919 | |
| 15675 | Gastric Bypass Surgery 2014.pdf | admin 30 May, 2021 | 231.06 Kb | 327 |