The effects of vitamin D administration on brain inflammatory markers in high fat diet induced obese rats
Mahdieh Abbasalizad Farhangi, Mehran Mesgari-Abbasi, Ghazaleh Nameni, Ghazaleh Hajiluian and Parviz Shahabi
BMC NeuroscienceBMC series – 201718:81, https://doi.org/10.1186/s12868-017-0400-1© The
This study echos many previous studies with humans - less weight gain and even lose weight with vitamin D
- Less weight gain if more vitamin D (in rats) – 2017 very similar results to the study on this page
- Overweight and obese lost 12 lbs with vitamin D in 6 months– RCT May 2015
- Dieters lost 5 more pounds if achieved more than 32 ng of vitamin D – RCT March 2014
- Infant risk of obesity increased by 50 percent if low vitamin D during pregnancy – Sept 2015
- Obesity 1.5 X more likely if poor Vitamin D receptor – Dec 2017
- Low-calorie diets mimicked by Vitamin D – Dec 2016
- Obesity linked to 13 cancers, the linkage is probably vitamin D – Aug 2016
- Vitamin D activates the hypothalamus (in rodents) to reduce weight and diabetes– May 2016
- Vitamin D stored in fatty tissue may have half life of 12 months (vs 2 months otherwise) – July 2017
Obese with enough Vit D in the Fall may have better Vit D in the Spring than non-obese. Is adding weight a way that the body tries to deal with low Vit D in the winter?
Overview Obesity and Vitamin D contains the following summary
- FACT: People who are obese have less vitamin D in their blood
- FACT: Obese need a higher dose of vitamin D to get to the same level of vit D
- FACT: When obese people lose weight the vitamin D level in their blood increases
- FACT: Adding Calcium, perhaps in the form of fortified milk, often reduces weight
- FACT: 168 trials for vitamin D intervention of obesity as of Dec 2021
- FACT: Less weight gain by senior women with > 30 ng of vitamin D
- FACT: Dieters lost additional 5 lbs if vitamin D supplementation got them above 32 ng - RCT
- FACT: Obese lost 3X more weight by adding $10 of Vitamin D
- FACT: Those with darker skins were more likely to be obese Sept 2014
- OBSERVATION: Low Vitamin D while pregnancy ==> more obese child and adult
- OBSERVATION: Many mammals had evolved to add fat and vitamin D in the autumn
- and lose both in the Spring - unfortunately humans have forgotten to lose the fat in the Spring
- SPECULATION: Low vitamin D might be one of the causes of obesity – several studies
- SUGGESTION: Probably need more than 4,000 IU to lose weight if very low on vitamin D due to
risk factors such as overweight, age, dark skin, live far from equator,shut-in, etc. - Obesity category has
442 items See also: Weight loss and Vitamin D - many studies Child Obesity and Vitamin D - many studies Obesity, Virus, and Vitamin D - many studies
Obese need more Vitamin D- Normal weight Obese (50 ng = 125 nanomole)
Download the PDF from VitaminDWiki
Rats gained less weight if take Vitamin D (independant of amount of fat in diet)
Background
Obesity induced brain inflammation is associated with cognitive disorders. We aimed to investigate the influence of vitamin D on hypothalamus and hippocampus inflammatory response in high-fat diet induced obese rats.Methods
In the beginning of the study, 40 rats were divided into two groups: control diet and high fat diet (HFD) for 16 weeks; then each group subdivided into two groups including: N, ND + vitamin D, HFD and HFD + vitamin D. Vitamin D supplementation was done for 5 weeks at 500 IU/kg dosage. IL-6, IL-1β, NF-Kβ and acetylcholine (ACH) and brain derived neurotropic factor (BDNF) concentrations in hippocampus and hypothalamus homogenate samples were measured by commercial ELISA kits.Results
Vitamin D administration, reduced food intake and weight gain in studied groups (P < 0.001). Vitamin D reduced hippocampus acetylcholine concentrations in ND + vitamin D group (P < 0.001). High fat diet increased hippocampus IL-6 concentrations significantly (P < 0.05) compared with normal diet receiving groups. Vitamin D could not have significant effects on IL-6 concentrations. Vitamin D administrations reduced IL-1β, NF-Kβ and acetylcholine concentration and BDNF concentrations in ND + vitamin D compared with ND group. These reductions were not significant in HFD + vitamin D versus HFD group.Conclusion
According to our results, vitamin D reduced food intake and weight gain and modulated the HFD induced inflammatory response in hippocampus and hypothalamus of high fat diet induced obesity. Therefore, this neurosteroid, can be suggested as a supplemental therapeutic tool in prevention of obesity related cognitive and neurodegenerative problems.Less weight gain if add Vitamin D, even if have a high fat diet (in rats) – RCT Dec 2017Printer Friendly Follow this page for updates7911 visitors, last modified 17 Jul, 2018, This page is in the following categories (# of items in each category)Attached files
ID Name Uploaded Size Downloads 9102 Weight gain.jpg admin 02 Jan, 2018 23.65 Kb 727 9100 High fat diet.pdf admin 02 Jan, 2018 897.63 Kb 1040