Effects of Calcium Plus Vitamin D Supplementation on Anthropometric Measurements and Blood Pressure in Vitamin D Insufficient People with Type 2 Diabetes: A Randomized Controlled Clinical Trial.
J Am Coll Nutr. 2015 Mar 4:1-9. [Epub ahead of print]
Tabesh M1, Azadbakht L, Faghihimani E, Tabesh M, Esmaillzadeh A.
50,000 IU vitamin D weekly + 1000 mg/d Calcium vs placebos
Systolic blood pressure reduced by 8 mmHg in 8 weeks
Suspect weight loss would have been measured if any of the following
- Trial had lasted longer than 8 weeks (takes >12 weeks for that dose to be effective)
- More vitamin D was used (obese need 2-3X more vitamin D)
- Magnesium was also used
Background: Up to 75% of the risk of type 2 diabetes is attributable to obesity. Therefore, finding a way to control obesity can be useful for management of diabetes. Objective: This study was performed to assess the effects of vitamin D3 and calcium supplementation on anthropometric measurements and blood pressure in vitamin D insufficient people with type 2 diabetes.
Methods: One hundred eighteen patients with diabetes were enrolled in this randomized placebo-controlled clinical trial. All subjects were randomly assigned into 4 groups receiving
- (1) 50,000 IU/wk vitamin D3 plus (equal to 7143 IU/d) calcium placebo;
- (2) 1000 mg/d calcium plus vitamin D3 placebo;
- (3) 50,000 IU/wk vitamin D3 (equal to 7143 IU/d) plus 1000 mg/d calcium; or
- 4) vitamin D3 placebo plus calcium placebo for 8 weeks.
Anthropometric measurements and blood pressure were assessed at study baseline and after 8 weeks of intervention.
Results: A greater reduction in body mass index was observed in calcium plus vitamin D group than other groups (p = 0.03). Comparison of changes in waist circumference among 4 groups revealed no significant difference in crude model (p = 0.21) and when the effect of confounders was taken into account (p = 0.08). Calcium supplementation resulted in a significant reduction in hip circumference compared to other groups (p <0.001). Systolic blood pressure significantly decreased in the calcium plus vitamin D group compared to placebo (-7.3 ± 8.7 mmHg vs 0.5 ± 8.2 mmHg; p = 0.001). However, calcium and vitamin D supplementation had no significant effects on diastolic blood pressure.
Conclusion: Calcium-vitamin D3 cosupplementation can have beneficial effect on body mass index (BMI), hip circumference, and systolic blood pressure in vitamin D-insufficient type 2 diabetics.
PMID: 25738212
See also VitaminDWiki
Pages listed in BOTH the categories Diabetes and Obesity
- Water-soluble form of vitamins are needed for some health problems
- Metabolic Syndromes fought by Vitamin D in 6 ways – Oct 2023
- UV reduces cardiovascular and metabolic problems– Vitamin D plus Nitric oxide – Sept 2023
- Vitamin D both reduces CVD directly and reduces metabolic problems that cause CVD – May 2023
- Non-alcoholic fatty liver disease: 75 percent of overweight adults and type II diabetics – Aug 2022
- Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes - Jan 2021
- The Role of Magnesium in the Pathogenesis of Metabolic Disorders – April 2022
- Vitamin D might a risk factor of insulin resistance, diabetes, obesity, etc. (50 ng) – Oct 2021
- COVID-19 hospitalizations: 63% associated with diabetes, obesity, hypertension or heart failure – Feb 2021
- 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D
- 90 percent remission of recently diagnosed diabetes with a low-calorie diet
- Resveratrol improves health (Vitamin D receptor, etc.) - many studies
- Waist size reduced 3 cm by Vitamin D in those with Metabolic Syndrome – Jan 2017
- Type II Diabetes is not prevented by a small amount of vitamin D (proven again) – May 2017
- Vitamin D activates the hypothalamus (in rodents) to reduce weight and diabetes– May 2016
- Autistic child 3X more likely if mother was obese and diabetic (both associated with low vitamin D) - Feb 2015
- Diabetes is more likely if low vitamin D than if obese - Feb 2016
- Off Topic: Diabetes 11X increase for just 150 calories of sugar - June 2015
- Obese diabetics with dark skins not benefit from 6,000 IU of vitamin D daily (no surprise) – RCT March 2015
- Vitamin D3 is stored in fat has not been processed by liver – March 2015
- Diabetic hypertension reduced with Vitamin D and Calcium – RCT March 2015
- Hypothesis- Metabolic disease is due to Tissue Renin-Angiotensin Systems – Feb 2014
- Higher vitamin D at birth associated with less diabetes and obesity 35 years later – Jan 2014
- Hypothesis: Obesity causes vitamin D deficiency and type 2 diabetes - 2012
- Insulin sensitivity in obese adolescents greatly improved with 4000 IU of vitamin D - RCT April 2013
- Metabolic Syndrome 10% less likely for every 4 ng increase in Vitamin D – Jan 2013
- No association between diabetes level and vitamin D insufficiency in obese youth – Jan 2013
- African-Americans at high risk of obesity and diabetes - 2011
- Diabetes 6X more likely for those abdominal obese who have insufficient vitamin D – June 2012
- Low vitamin D associated with obesity-related diseases for ethnic minorities – Sept 2011
- Obesity lowers vitamin D which increases probability of diabetes in children – Nov 2011
- Obesity and diabetes reduced when move to better neighborhood – or better UV – Oct 2011
- Vitamin D Levels at Birth May Predict Obesity Risk at age 3 - Oct 2010
- Overview Metabolic Syndrome and vitamin D
- More obese had less vitamin D, and after low calorie diet, vitamin D went up – June 2010
- Vitamin D and Obesity from vitamin D council newsletter of Nov 2006
Pages listed in BOTH the categories Magnesium and Obesity
- Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes - Jan 2021
- The Role of Magnesium in the Pathogenesis of Metabolic Disorders – April 2022
- More Magnesium needed by obese (Mg Sulfate, women in this case) – RCT Dec 2021
- PTH failed to decrease with Vitamin D if overweight and had low Magnesium – Aug 2019
- Magnesium may help with calorie restriction, ALS, and R-loops in DNA - LEF Oct 2017
- Heart problems in obese increase if deficient in BOTH Vitamin D and Magnesium – Aug 2017
- Obesity epidemic: a perfect storm of deficiency of vitamin D, Magnesium, Iodine, etc – May 2012
- Obesity pandemic since 1975 - is it due to Vitamin D, Magnesium, Iodine, adenovirus, or what
- Reasons for low response to vitamin D
- Weight loss and Vitamin D, Calcium, and Magnesium
- Overview Magnesium and vitamin D
Pages listed in BOTH the categories Magnesium and Diabetes
- Vitamin D Roles - more than just help the immune system
- Retinopathy in males 6.9 X more likely if low vitamin D and low Magnesium - June 2024
- Magnesium Depletion Score predicts increased risk of various health problems
- High fluoride in water: 5X more likely to be Vitamin D deficient – Jan 2023
- Diabetes, Metabolic Syndrome and Magnesium - many studies
- More Magnesium needed to decrease diabetes, cardio, HT (body weight has increased) - March 2021
- Treating pre-diabetes with Magnesium Chloride should be cost effective – June 2022
- Reduced Magnesium is associated with reduced health (Diabetes in this case) - April 2022
- Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes - Jan 2021
- The Role of Magnesium in the Pathogenesis of Metabolic Disorders – April 2022
- Magnesium fights diabetes (yet again)– meta-analysis Nov 2021
- Excessive insulin decreases vitamin D in 4 ways – problems for diabetic COVID-19 – Dec 2020
- Low Magnesium associated with diabetes, etc. – meta-analysis 2016
- Low Level Laser Therapy greatly increased Vitamin D and Magnesium (for diabetics with nephropathy) – March 2019
- Young Diabetics had 3.8 X higher risk of Parkinson’s (perhaps low Mg or low Vitamin D)– June 2018
- Cardiometaboic problems decreased with increased Vitamin D, unless low Magnesium – Aug 2017
- Diabetes 29 % less likely if consume lots of Magnesium and cereal fiber (surveys of 200,000 people) – Oct 2017
- Magnesium is associated with prevention and treatment of Diabetes – Meta-analysis Aug 2016
- Type 2 diabetes associated with low Magnesium
- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
- More vitamin D makes for better health – dissertation based on Rotterdam studies – Oct 2015
- Prediabetes reduced in half by those getting Magnesium Chloride – RCT April 2015
- Type II Diabetes might be prevented and treated with Magnesium – Review Feb 2015
- Diabetes decreased with 300 mg of Mg (Mg Sulfate) – RCT July 2014
- Daily Magnesium improved all aspects of metabolic profile – RCT July 2014
- Diabetes and low Magnesium - Mercola 2014 - 2019
- Diabetics have problems with low Magnesium, especially if taking statins – Aug 2013
- Low Magnesium and type II diabetes – June 2012
- Hypothesis: Decreasing Magnesium and increasing CaMg ratio are increasing health problems – 2012 - 2013
- Reduced chance of diabetes 46 percent with Magnesium - Oct 2010