Effect of Monthly Vitamin D Supplementation on Preventing Exacerbations of Asthma or Chronic Obstructive Pulmonary Disease in Older Adults: Post Hoc Analysis of a Randomized Controlled Trial
Nutrients 2021, 13(2), 521; https://doi.org/10.3390/nu13020521
by Carlos A. Camargo, Jr. 1,*OrcID,Les Toop 2OrcID,John Sluyter 3OrcID,Carlene M. M. Lawes 3,Debbie Waayer 3OrcID,Kay-Tee Khaw 4,Adrian R. Martineau 5 and Robert Scragg 3OrcID
This study is a subset of the following, and had only 18 people with <10 ng of vitamin D
Study did not accept people supplementing with more than 600 or 800 IU of vitamin D
Monthly 100,000 IU of vitamin D is safe (and may be better than daily) – RCT Aug 2018
Overview Asthma and Vitamin D contains
- VitaminDWiki pages containing ASTHMA in title (164 as of Nov 2024)
- Asthma attacks reduced in half if Vitamin D level higher than 42 nanograms – RCT May 2014
- Started with 100,000 IU loading dose and has standard-of-care Asthma drug
- Asthma may be treated by Vitamin D if more than 40 ng for 12 months – Sept 2018
- Those with Asthma or COPD had half the response to Vitamin D – March 2020
- Those with Asthma need larger doses to get the same response.
- Probably need gut-friendly Vitamin D
- CDC funded study: 1.3 X Asthma risk if vaccination contained aluminum – Sept 2022
- Asthma occurrence rate reduced 3X by Vitamin D – 8 study meta-analysis - Aug 2021
- Asthma in child 2.3 X more likely if both parents asthmatic (unless add Vitamin D) – VDAART Nov 2018
- Adult-onset asthma 2X more likely if low vitamin D and not hyperallergenic – May 2018
- Children had poor lung function if mothers had low vitamin D while pregnant – Nov 2022
- 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D
- CDC list of high-risk for COVID-19 includes Asthma
- Child Asthma increased 2.1 X by antibiotics, Child milk allergy increased 4.4 X by PPI – April 2018
- Asthmatic children taking Corticosteroids had 2X more vitamin D intake, but lower levels – July 2017
- Traffic pollution increases asthma unless supplement with Vitamin D (mice) June 2018
- Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017
- Proof that Vitamin D Works 92 health problems prevented/treated as of Nov 2020
- Asthma has been proven to be treated by Vitamin D in at least 4 random controlled trials
- Childhood asthma still reduced 4 months after 800 IU of Vitamin D daily - RCT Feb 2016
- Respiratory Disease exacerbations (Asthma, CF, COPD) may be treated by Vitamin D – July 2019
- Women with asthma 35X more likely to be vitamin D deficient – Oct 2013
- If high vitamin D during pregnancy the child is 5X less likely to get asthma
- Asthma is treated by Vitamin D – now they are trying to understand why – Feb 2015
- Increase in vitamin D deficiency may partially explain increases in asthma and allergies – Jan 2015
- Why deficiencies in vitamin D and magnesium are linked to asthma Magnesium allows muscles to relax
- Babies 3.6X more likely to go to hospital for asthma if asthmatic mother had low vitamin D while pregnant – June 2019
- The worse the bronchial asthma, the lower the vitamin D – Jan 2017 has the following chart
click on the chart to see the study
- One pill every two weeks gives you all the vitamin D most adults need
- Vitamin D update – 40-60 ng ideal, 50K biweekly maintenance – Jan 2014
- Stoss (loading) dose of vitamin D resulted in bigger response at 30 days (again) – RCT April 2021
- Pregnancies helped a lot by Vitamin D (injection then 50,000 IU monthly) – RCT May 2018
- 100,000 IU of vitamin D monthly decreases use of NASIDs by 13 percent if low vitamin D – RCT May 2018
- Autism treated by Vitamin D (monthly injection of 150,000 IU) – June 2017
- Less bone loss if take 100,000 IU vitamin D monthly – RCT Nov 2017
272 items in category Intervention - non daily
VitaminDWiki - Weekly, Monthly Vitamin D are typically better than daily - many studies
COPD fought by Vitamin D - many studies has the following
- Vitamin D is one of the alternate COPD therapies – March 2021
- COPD treated by Vitamin D – meta-analysis March 2022
- COPD quality of life improved by 400,000 IU Vitamin D loading dose – RCT July 2019
- COPD exacerbations 2X less often if low vitamin D then supplemented – meta-analysis Jan 2019
- Worse breathing with COPD is related to lower Vitamin D – June 2018
- COPD ICU stay is 2.4 days longer if low vitamin D – Oct 2015
- COPD and Vitamin D, concise (46 page) review – Dec 2016
- 100000 IU vitamin D monthly helps COPD patients – 3 RCT
- Those with Asthma or COPD had half the response to Vitamin D – March 2020
VitaminDWiki -Weekly, Monthly Vitamin D are typically better than daily - many studies
Download the PDF from VitaminDWiki
Only 18 people had < 10 ng of vitamin D
Randomized controlled trials have suggested that vitamin D supplementation can prevent asthma and chronic obstructive pulmonary disease (COPD) exacerbations. For COPD, the benefit appears to be limited to individuals with baseline 25-hydroxyvitamin D (25OHD) levels <25 nmol/L. We performed a post hoc analysis of data from a randomized, double-blinded, placebo-controlled trial to investigate the effect that monthly, high-dose vitamin D supplementation (versus placebo) had on older adults with asthma and/or COPD. Specifically, we investigated whether vitamin D supplementation prevented exacerbations of these conditions.
Participants were randomly assigned either to an initial oral dose of 200,000 IU vitamin D3 followed by 100,000 IU monthly or to placebo, with an average follow-up period of 3.3 years. Among the 5110 participants, 775 had asthma or COPD at the beginning of the study, and were eligible for inclusion in this analysis. Exacerbations were defined by the prescription of a short-burst of oral corticosteroids. The mean age of the participants was 67 years old, and 56% were male. The mean baseline blood 25OHD level was 63 nmol/L; 2.3% were <25 nmol/L. Overall, we found that vitamin D supplementation did not affect the exacerbation risk (hazard ratio 1.08; 95%CI 0.84–1.39). Among those with baseline 25OHD <25 nmol/L, however, the hazard ratio was 0.11 (95%CI 0.02–0.51); p for interaction = 0.001. Although monthly vitamin D supplementation had no overall impact on risk of exacerbations of asthma or COPD, we found evidence of a probable benefit among those with severe vitamin D deficiency. View Full-Text
Asthma and COPD in a few seniors greatly decreased by monthly 100,000 IU Vitamin D – RCT Feb 2021Printer Friendly Follow this page for updates7090 visitors, last modified 17 Mar, 2024, This page is in the following categories (# of items in each category)Attached files
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