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The role of vitamin D in gastrointestinal inflammation (behind a 89 dollar paywall) – July 2014

Expert Review of Gastroenterology & Hepatology (doi:10.1586/17474124.2014.925796)
Simon Ghaly and Ian Lawrance Ian.Lawrance at uwa.edu.au
Centre for Inflammatory Bowel Diseases, Fremantle Hospital and School of Medicine and Pharmacology, University of Western Australia, Level 5, T Block, Alma St, Fremanlte, Western Australia 6159, Australia

The emerging role of vitamin D as a regulator of both innate and adaptive immune responses has encouraged the investigation of its role in the pathogenesis of a variety of autoimmune conditions including the

inflammatory bowel diseases (IBD),
Crohn’s disease and
ulcerative colitis.

Animal models consistently demonstrate that vitamin D significantly impacts on the modulation of astrointestinal inflammation, while epidemiological and observational data show an inverse relationship between vitamin D status and the onset/progression of Crohn’s disease as well as the development of colorectal cancer. As vitamin D supplementation is readily available, at low cost, it is a very attractive potential therapeutic option. The biological plausibility for a role for vitamin D in inflammation modulation, the potential genetic links associated with vitamin D metabolism and the clinical aspects for it in IBD will be discussed.

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The role of vitamin D in gastrointestinal inflammation (behind a 89 dollar paywall) – July 2014

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