- Impact of Rapid Correction of Vitamin D Deficiency on Patients with COVID-19 Disease: A Randomized-Controlled Trial
- VitaminDWiki – COVID-19 treated by Vitamin D - studies, reports, videos
- VitaminDWiki – Over 715 virus studies have Vitamin D in the title
- BOTH Virus AND Intervention categories (
51 pages)
Impact of Rapid Correction of Vitamin D Deficiency on Patients with COVID-19 Disease: A Randomized-Controlled Trial
The Egyptian Journal of Hospital Medicine (July 2024) Vol. 96, Page 2538-2546
Ayman Ramadan Abdelhai 1, Amir Abd-Elhameed Ahmed Barakat 1,
Marwa M. Esawy 2, May M. Sami 2, Ahmed Ibrahim Gad1
Departments of 1 Internal Medicine, 2 Clinical Pathology, Faculty of Medicine, Zagazig University, Egypt
Summary and notes by VitaminDWiki
- 4 days of 200,000 IU Vitamin D intramuscular injections while in ICU for COVID
- The “control group” got 10,000 IU daily for 4 days
- Vitamin D Injections act slowly – better to have fast-acting Sublingual vitamin D for 4 days
- Would have been much better if patients had gotten Vitamin D BEFORE entering in ICU
- Vitamin D level achieved: 32 ng. Even less Mortality expected if they had used larger doses (and get >40 ng)
- Founder of VitaminDWiki bought >20 lbs of Vitamin D in 2020 to give away free - but could not find a single taker
- Founder of VitaminDWiki tried to start an RCT in 2020 using 400,000 IU of vitamin D, but was stopped by local corruption
Background: Although antiviral properties of vitamin D are recognized, the influence of parental Vit D supplementation
on COVID-19 disease has not been determined.Objective: The aim of study was to evaluate impact of prompt treatment of Vit D deficiency on COVID-19 patients.
Patients and Methods: A randomized controlled experiment was carried out on 250 COVID-19 patients. Patients were
categorized into two cohorts: one cohort received daily intramuscular injection of 200,000 IU cholecalciferol for four
consecutive days, while other cohort received daily oral dose of 10,000 IU cholecalciferol. The latter group functioned as
control group. Before and after therapy, serum 25(OH)D level, inflammatory markers and electrolytes were measured,
besides, clinical follow-up.Results: In Vit D group, the 25(OH)D levels considerably increased after 7 days compared to initial levels (32.48 ±9.64 Vs
13.77 ±6.51 ng/mL, respectively). All Vit D deficient patients have transitioned to sufficient status. Levels of markers (ESR
50.99±17.56 mm/hr, CRP 30.75 ±24 mg/L, and ferritin 392.05 ±139.17 ng/mL) decreased after seven days (29.74±8.97
mm/hr, 10.52 ±13 mg/L, and 94.59 ±27.14 ng/mL, respectively). A substantial clinical improvement occurred in Vit D
group compared to their initial condition.
Also Vit D deficiency was found to significantly increase risk of COVID-19 mortality by factor of 15.375 [AOR = 15.375, 95% CI: 1.898-124.52, p=0.01].Conclusion: A daily intramuscular injection of 200,000 IU cholecalciferol for four consecutive days has been proven to
significantly enhance clinico-labatory parameters in COVID-19 patients. Considering higher Vit D supplementation as
a potential treatment for COVID-19 is a viable option
 Download the PDF from VitaminDWiki
33 REFERENCES
- Alhazzani W, Moller M, Arabi Y et al. (2020): Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19). Intensive Care Med., 46:854-87.
- Zhang R, Li B, Gao X et al. (2017): Serum 25- hydroxyvitamin D and the risk of cardiovascular disease: dose-response meta-analysis of prospective studies. Am J Clin Nutr., 105:810-9.
- Zisi D, Challa A, Makis A (2019): The association between vitamin D status and infectious diseases of the respiratory system in infancy and childhood. Hormones (Athens), 18:353-63.
- Holick M, Binkley N, Bischoff-Ferrari H et al. (2011): Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab., 96:1911-30.
- Merzon E, Tworowski D, Gorohovski A et al. (2020): Low plasma 25(OH) vitamin D level is associated with increased risk of COVID-19 infection: an Israeli population-based study. Febs J., 287:3693-702.
- Roth D, Abrams S, Aloia J et al. (2018): Global prevalence and disease burden of vitamin D deficiency: a roadmap for action in low- and middle-income countries. Ann N Y Acad Sci., 1430:44-79.
- Botros R, Sabry I, Abdelbaky R et al. (2015): Vitamin D deficiency among healthy Egyptian females. Endocrinol Nutr., 62:314-21.
- Hurwitz J, Jones B, Penkert R et al. (2017): Low retinolbinding protein and vitamin D levels are associated with severe outcomes in children hospitalized with lower respiratory tract infection and respiratory syncytial virus or human metapneumovirus detection. J Pediatr., 187:323-7.
- Grant W, Lahore H, McDonnell S et al. (2020): Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths. Nutrients, 12:3533-9.
- Ilie P, Stefanescu S, Smith L (2020): The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality. Aging Clin Exp Res., 32:1195-8.
- Daneshkhah A, Eshein A, Subramanian H et al. (2020): The role of vitamin D in suppressing cytokine storm in COVID-19 patients and associated mortality. MedRxiv., 12:9.
- Ezeamama A, Guwatudde D, Wang M et al. (2016): Vitamin-D deficiency impairs CD4+T-cell count recovery rate in HIV-positive adults on highly active antiretroviral therapy: A longitudinal study. Clin Nutr., 35:1110-7.
- Adams J, Ren S, Liu P et al. (2009): Vitamin D-directed rheostatic regulation of monocyte antibacterial responses. J Immunol., 182:4289-95.
- Gombart AF, Pierre A, Maggini S (2020): A review of micronutrients and the immune system-working in harmony to reduce the risk of infection. Nutrients, 12:33-36.
- Shabana M, Esawy M, Ismail N et al. (2019): Predictive role of IL-17A/IL-10 ratio in persistent asthmatic patients on vitamin D supplement. Immunobiology, 224:721-7.
- Jafarzadeh A, Chauhan P, Saha B et al. (2020): Contribution of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential therapeutic interventions. Life Sci., 257:118102.
- Suaini N, Zhang Y, Vuillermin P et al. (2015): Immune modulation by vitamin D and its relevance to food allergy. Nutrients, 7:6088-108.
- Greiller C, Martineau A (2015): Modulation of the immune response to respiratory viruses by vitamin D. Nutrients, 7:4240-70.
- Hathcock J, Shao A, Vieth R et al. (2007): Risk assessment for vitamin D. Am J Clin Nutr., 85:6-18.
- Haimovich A, Ravindra N, Stoytchev S et al. (2020): Development and validation of the Quick COVID-19 Severity Index: A prognostic tool for early clinical decompensation. Ann Emerg Med., 76:442-53.
- Bischoff-Ferrari H, Giovannucci E, Willett W et al. (2006): Estimation of optimal serum concentrations of 25- hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr., 84:18-28.
- Westergren A (1926): The technique of the red cell sedimentation reaction. American Review of Tuberculosis, 14:94-101.
- Meltzer D, Best T, Zhang H et al. (2020): Association of vitamin D status and other clinical characteristics with COVID-19 test results. JAMA Netw Open, 3:e2019722.
- Martineau A, Jolliffe D, Hooper R et al. (2017): Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ., 356:i6583.
- Dixon B, Barker T, McKinnon T et al. (2012): Positive correlation between circulating cathelicidin antimicrobial peptide (hCAP18/LL-37) and 25-hydroxyvitamin D levels in healthy adults. BMC Res Notes, 5:575.
- Zdrenghea M, Makrinioti H, Bagacean C et al. (2017): Vitamin D modulation of innate immune responses to respiratory viral infections. Rev Med Virol., 27:45-49.
- Jakovac H (2020): COVID-19 and vitamin D-Is there a link and an opportunity for intervention? Am J Physiol Endocrinol Metab., 318:E589.
- Maghbooli Z, Sahraian M, Ebrahimi M et al. (2020): Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection. PLoS One, 15:e0239799.
- Rastogi A, Bhansali A, Khare N et al. (2022): Short term, high-dose vitamin D supplementation for COVID-19 disease: a randomised, placebo-controlled, study (SHADE study). Postgrad Med J., 98:87-90.
- Tellioglu A, Basaran S, Guzel R et al. (2012): Efficacy and safety of high dose intramuscular or oral cholecalciferol in vitamin D deficient/insufficient elderly. Maturitas, 72:332-8.
- Amrein K, Sourij H, Wagner G et al. (2011): Short-term effects of high-dose oral vitamin D3 in critically ill vitamin D deficient patients: a randomized, double-blind, placebocontrolled pilot study. Crit Care, 15:R104.
- Kearns M, Alvarez J, Tangpricha V (2014): Large, single-dose, oral vitamin D supplementation in adult populations: a systematic review. Endocr Pract., 20:34151.
- Velavan T, Meyer C (2020): Mild versus severe COVID-19: Laboratory markers. Int J Infect Dis., 95:304-7.
VitaminDWiki – COVID-19 treated by Vitamin D - studies, reports, videos
As of March 31, 2024, the VitaminDWiki COVID page had: trial results, meta-analyses and reviews, Mortality studies see related: Governments, HealthProblems, Hospitals, Dark Skins, All 26 COVID risk factors are associated with low Vit D, Fight COVID-19 with 50K Vit D weekly Vaccines Take lots of Vitamin D at first signs of COVID 166 COVID Clinical Trials using Vitamin D (Aug 2023) Prevent a COVID death: 9 dollars of Vitamin D or 900,000 dollars of vaccine - Aug 2023
5 most-recently changed Virus entries- The above image is automatically updated
VitaminDWiki – Over 715 virus studies have Vitamin D in the title
BOTH Virus AND Intervention categories (
51 pages) - Viral infections reduced 40% by monthly 100,000 IU Vitamin D – RCT review Aug 2024
- Long-COVID fatigue, anxiety, and cognition treated by 60,000 IU of vitamin D weekly – RCT July 2024
- 15.3 X fewer COVID deaths in those getting Vitamin D injections in ICU – RCT July 2024
- Multiple Vitamin D doses reduced COVID ICU by 2.5 X , Mech. Ventilation by 5.5 X – meta-analysis May 2024
- Single 600,000 IU dose of nanoemulsion Vitamin D is safe and effective to fight COVID, even if delay until enter ICU – RCT May 2024
- COVID death rate in hospital halved if take any amount of vitamin D for any length of time – meta-analysis May 2024
- COVID and Vitamin D: 2X more likely to die if low, 2X more likely to survive if supplement – umbrella meta-analysis April 2024
- COVID fought by Vitamin D: 2.3X less likely to die of COVID if supplemented, 1.9 X less likely to become infected – meta-analysis March 2024
- 5 X less COVID infection of health care workers who took lots of vitamin D – meta-analysis Feb 2024
- COVID deaths cut in half by a single dose of 600,000 IU of Vitamin D - RCT Jan 2024
- COVID in hospital stopped by Vitamin D Receptor activators (curcumin, quercetin) – RCT June 2023
- Vitamin D Supplements Don’t Reduce COVID-19 Risk (used only 3,200 IU daily) - Oct 2022
- High dose vitamin D fights Folate gene changes by COVID, autoimmune, CVD, ALZ – Oct 2022
- COVID in hospital fought by Vitamin D (25,000 IU daily for 4 days, then 25K weekly) - RCT – July 2022
- Small Vitamin D doses for a short time never help (not improve vaccination in this case) – RCT Sept 2022
- The challenges of a Vitamin D RCT – too many already taking it, etc. – Martineau Sept 2022
- Early COVID treatments rarely work 7 days after symptoms, this trial gave Vitamin D on 7th day – RCT May 2022
- COVID children helped by Vitamin D, trial terminated: unethical to not give Vitamin D to all: – RCT July 2022
- COVID hospital deaths reduced 2X by 8 days of UVB – pilot RCT May 2022
- 21 fewer days in hospital with ARDS (COVID) if 10,000 IU of Vitamin D daily after enter hospital – RCT April, 2022
- 4X less likely to get COVID following 4,000 IU daily for a month – RCT April 2022
- Risk of COVID not reduced by 3,200 IU of vitamin D during 6 months (no surprise) – RCT March 2022
- Group achieving 30 ng (vs 26 ng) were 2X less likely to get COVID symptoms - RCT Jan 2022
- Tested positive for COVID, taking probiotics stopped symptoms 5 days sooner - RCT Jan 2022
- Vitamin D given slowly in hospital did not fight COVID-19 much - Nov 2021
- Nursing home vaccinated against Influenza, 800 IU of vitamin D daily cut infection rate in half – small RCT Oct 2021
- COVID-19 appears reduced by Resveratrol plus 100K IU of vitamin D – Small RCT Sept 2021
- Vitamin D trial for COVID-19 – using their patented slow-release form – Aug 2021
- COVID-19 mortality reduced 4X (chart looks like 2X) by large, infrequent doses of Vitamin D in France – July 2021
- COVID-19 outpatients getting Quercetin nanoemulsion had excellent outcomes (Q increased Vitamin D in cells) – RCT – June 2021
- 5,000 U daily raised Vitamin D a bit and helped COVID-19 a bit – RCT June 2021
- COVID-19 inflammation extinguished by 60,000 IU of vitamin D nanoemulsion daily for a week – RCT May 2021
- Better response to shingles virus after 6,400 IU Vitamin D raised above 40 ng – Jan 2021
- COVID-19 ICU survival rate increased 7X by daily Omega-3 – RCT March 2021
- Kidney patients who happened to be getting high-dose Calcitriol were 9X less likely to die of COVID-19 - April 6, 2021
- Vitamin D not help 10 days after COVID-19 symptoms - RCT March 2021
- 5X less likely to enter ICU with COVID-19 if get Calcifediol (semi-activated vitamin D) - RCT Feb 19, 2021
- calcifediol rct
- COVID-19 defeated 3x faster by 420,000 IU Vitamin D nanoemulsion – RCT Nov 12, 2020
- COVID-19 defeated by calcifediol form of Vitamin D in Spain - pilot RCT Aug 29, 2020
- Swine flu not prevented by 2,000 IU of vitamin D daily (the upper limit at the time) – RCT 2014
- Influenza vaccine antibodies not change with Vitamin D – 21 ng or 44 ng – RCT Feb 2019
- Dengue virus prevented by a small amount of Vitamin D – RCT Nov 2019
- Half the risk of Influenza -A in infants taking 1200 IU of vitamin D for 4 months – RCT Jan 2018
- Chikungunya virus arthritis pain reduced by weekly 60,000 IU vitamin D – Sept 2016
- Many Infectious diseases (virus) treated and prevented by Vitamin D – review July 2009
- Influenza prevented by 40 ng levels or treated with vitamin D hammer (50,000 IU) – June 2015
- Infection fighting ability increased with 5,000 IU Vitamin D daily – April 2015
- Vitamin D prevents Hepatitis-C and helps treat it (many studies)
- Malaria in mice brains, and associated inflammation, prevented by Vitamin D intervention – July 2014
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