Alzheimer’s, Parkinson’s, Huntington’s, dementia etc. might be prevented by vitamin D (abstract only) – Sept 2024

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Tremendous Fidelity of Vitamin D3 in Age-related Neurological Disorders

Mol Neurobiol. 2024 Sep;61(9):7211-7238. doi: 10.1007/s12035-024-03989-w
Manjari Skv 1, Sharon Mariam Abraham 1, Omalur Eshwari 1, Kishore Golla 1, Priya Jhelum 2, Shuvadeep Maity 1, Pragya Komal 3

Vitamin D3 (VD) is a secosteroid hormone and shows a pleiotropic effect in brain-related disorders where it regulates redox imbalance, inflammation, apoptosis, energy production, and growth factor synthesis. Vitamin D3's active metabolic form, 1,25-dihydroxy Vitamin D3 (1,25(OH)2D3 or calcitriol), is a known regulator of several genes involved in neuroplasticity, neuroprotection, neurotropism, and neuroinflammation. Multiple studies suggest that VD deficiency can be proposed as a risk factor for the development of several age-related neurological disorders.
The evidence for low serum levels of 25-hydroxy Vitamin D3 (25(OH)D3 or calcidiol), the major circulating form of VD, is associated with an increased risk of Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), dementia, and cognitive impairment. Despite decades of evidence on low VD association with neurological disorders, the precise molecular mechanism behind its beneficial effect remains controversial. Here, we will be delving into the neurobiological importance of VD and discuss its benefits in different neuropsychiatric disorders. The focus will be on AD, PD, and HD as they share some common clinical, pathological, and epidemiological features.
The central focus will be on the different attributes of VD in the aspect of its

• anti-oxidative,
• anti-inflammatory,
• anti-apoptotic,
• anti-cholinesterase activity, and
• psychotropic effect

in different neurodegenerative diseases.

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VitaminDWiki – Overview Alzheimer's-Cognition and Vitamin D contains:

• FACT: Cognitive decline is 19X more likely if low vitamin D
• FACT: Dementia is associated with low vitamin D levels.
• FACT: Alzheimer’s Dementia 2.3X more likely in elderly if low vitamin D – Dec 2022
• FACT: Dementia is associated with low vitamin D - many studies
• FACT: Alzheimer's Disease is 4X less likely if high vitamin D
• FACT: Every single risk factor listed for Alzheimer's Disease is also a risk factor for low vitamin D levels
• FACT: Elderly cognition gets worse as the elderly vitamin D levels get even lower (while in senior homes)
• OBSERVATION: Reports of increased vitamin D levels result in improved cognition
• OBSERVATION: Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012
• OBSERVATION: Alzheimer's Disease has been seen to halt when vitamin D was added.
• OBSERVATION: Alzheimer’s is associated with all 7 of the genes which restrict vitamin D
• OBSERVATION: 39 vitamin D and Alz. or Cognition intervention trials as of Sept 2018
• OBSERVATION: 2 Meta-analysis in 2012 agreed that Alzheimer's Disease. associated with low vitamin D
• OBSERVATION: 50X increase in Alzheimer's while decrease in vitamin D
• OBSERVATION: Vitamin D reduces Alzheimer’s disease in 11 ways
• OBSERVATION: Alzheimer’s cognition improved by 4,000 IU of vitamin D
• OBSERVATION: Plaque removed in mice by equiv. of 14,000 IU daily
• OBSERVATION: DDT (which decreases Vit D) increases risk of Alzheimer's by up to 3.8X
• OBSERVATION: 2% of people have 2 copies of the poor gene reference: Alz Org
• OBSERVATION: Genes do not change rapidly enough to account for the huge increase in incidence
• OBSERVATION: End of Alzheimer's videos, transcripts and many studies protocol has been very successful
  • It adjusts Vitamin D, B-12, Iron, Omega-3, food, etc, and can now be done at home.
• FACT: Vitamin D is extremely low cost and has very very few side effects
• CONCLUSION: Everyone concerned about cognitive decline or Alzheimer's Disease should take vitamin D
• PREDICTION MET: By 2024 Omega-3 and high dose Vitamin D will be found to reverse Alzheimer's in humans
  There are 13+ Alzheimer’s meta-analyses in VitaminDWiki
  There are 97+ Alzheimer’s studies in VitaminDWiki
  Dementia is associated with low vitamin D - many studies 50+ studies
  16+ studies in both categories Cognitive and Omega-3

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VitaminDWiki - Overview Parkinson's and Vitamin D contains:

• Vitamin D associated with Parkinson’s Disease in 55 studies, more studies needed- March 2022
• Parkinson's category has 117 studies
• Parkinson’s Disease and Vitamin D – review of 52 studies – May 2022
• Parkinson patients: 60 % taking Vitamin D – Dec 2019
• Low Vitamin D increases Parkinson's by 3X– July 2010 "only" a 30 year test, need more study
• Parkinson's disease prevented by Vitamin D, but small doses do not treat it - Aug 2023
• 10 clinical trials for PD with vitamin D intervention as of June 2023
• Parkinson’s Disease Summer School – alternative therapies included 60-80 ng of Vitamin D – Sept 2019
• Associated with PD are: Meta-analyses (12 ), Cognition (24 studies), Multiple Sclerosis (18 studies), VIRUS (4 studies), Omega-3 (3 studies), Vitamin D Receptor (11 studies)
• Note by the Founder of VitaminDWiki: I have twice recommended lots of Vitamin D to treat PD. Both got much better, but one had his doctor him cut back to just 2,000 IU. All of his recovery got reversed. With lots of vitamin D he could sing and bike, but now he can barely talk or walk

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VitaminDWiki - Huntington disease patients – ALL had low vitamin D levels – Sept 2014

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VitaminDWiki - Dementia is associated with low vitamin D - many studies 63+

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Might Vitamin D prevent any of the following diseases: Alzheimer's, Parkenson's, and Huntington? asked Perplexity AI Aug 2024

Based on the provided search results, there is evidence suggesting that vitamin D deficiency may be associated with an increased risk of several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. However, the exact role of vitamin D in preventing these diseases is not fully understood and requires further research.

Alzheimer's Disease

• Epidemiological studies indicate a relationship between vitamin D deficiency and Alzheimer's disease (AD). Patients with AD have been found to have lower levels of serum 25(OH)D3 compared to healthy controls.
• Vitamin D deficiency has been associated with a 21% increased risk of AD.
• Low serum vitamin D levels (<30 ng/ml) and polymorphisms of the vitamin D receptor have been associated with AD.

Parkinson's Disease

• Vitamin D deficiency appears to be common in Parkinson's disease (PD) patients.
• Vitamin D has been shown to have antioxidative and anti-inflammatory properties, which may provide neuroprotection in PD.

Huntington's Disease

• Vitamin D deficiency is common among Huntington's disease patients, with up to 89% having insufficient levels (<50 nmol/L).
• There is evidence of disease-specific alterations in bone metabolism and increased fracture risk in Huntington's disease patients, which may be related to vitamin D deficiency.

While these findings suggest a potential role for vitamin D in the prevention of neurodegenerative diseases, the causal link is still a matter of debate. Randomized clinical trials examining vitamin D supplementation in patients with these disorders are needed to determine the optimal timing, efficacy, and appropriate dosing.It is important to note that vitamin D interacts with various mechanisms and may be a potential multitargeted therapeutic option for prevention and protection from cognitive decline and neurodegeneration.