On the job sleepiness 2.2X more likely if low vitamin D – Feb 2020

Impacts of Serum Vitamin D Levels on Sleep and Daytime Sleepiness According to Working Conditions

J Clin Sleep Med, 2020 Feb 21, DOI: 10.5664/jcsm.8390
Hyuk Joo Lee 1, Hayun Choi 2, In-Young Yoon 1 3

 Download the PDF from Sci-Hub via VitaminDWiki

Little change in Vitamin D level with season for day-workers

Study objectives: Low serum vitamin D levels are known to be associated with working conditions and poor sleep, but precedent studies on this issue were limited by the absence of objective sleep measurements or clear distinction between daytime and night shift work. Hence, we aimed to examine serum vitamin D levels and sleep in daytime and night-shift workers using actigraphy.

Methods: A total of 412 night-shift and 432 daytime workers at Seoul National University Bundang Hospital were recruited. All participants completed questionnaires regarding demographic and clinical characteristics. They underwent blood tests for serum vitamin D levels. Objective sleep data were obtained from 150 night-shift workers and 203 daytime workers using actigraphy.

Results: There was no significant difference in serum vitamin D levels between night-shift and daytime workers after controlling for possible confounders.
In daytime workers, vitamin D deficiency was closely related to

• shorter duration of total sleep time [odds ratio (OR): 3.07, 95% confidence interval (CI): 1.51 - 6.26, P = 0.002] and
• higher risk of excessive daytime sleepiness (OR: 2.20, 95% CI: 1.30 - 3.74, P = 0.003).

Deficient vitamin D was also associated with

• life quality impairment regarding psychological health (OR: 1.83, 95% CI: 1.07 - 3.29, P = 0.028) and
• social relationship (OR: 1.78, 95% CI: 1.10 - 2.88, P = 0.020).

However, in night-shift workers, no significant association was observed between serum vitamin D level and sleep parameters, depressive/anxiety symptoms, or quality of life.

Conclusions: The modest adverse impact of poor vitamin D status on sleep could be attenuated by substantial shift work-related sleep disturbances in night-shift workers. Further studies might be needed to clarify the beneficial effect of vitamin D supplementation for improving sleep and daytime sleepiness in workers with various working conditions.

REFERENCES

• 1. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266–281. https://doi.org/10.1056/NEJMra070553
• 2. Forman JP, Giovannucci E, Holmes MD, et al.. Plasma 25-hydroxyvitamin D levels and risk of incident hypertension. Hypertension. 2007;49(5):1063–1069. https://doi.org/10.1161/HYPERTENSIONAHA.107.087288
• 3. Anglin RE, Samaan Z, Walter SD, McDonald SD. Vitamin D deficiency and depression in adults: systematic review and meta-analysis. Br J Psychiatry. 2018;202(2):100–107. https://doi.org/10.1192/bjp.bp.111.106666
• 4. Garland CF, Garland FC, Gorham ED, et al.. The role of vitamin D in cancer prevention. Am J Public Health. 2006;96(2):252–261. https://doi.org/10.2105/AJPH.2004.045260
• 5. Eyles D, Liu P, Josh P, Cui XJN. Intracellular distribution of the vitamin D receptor in the brain: comparison with classic target tissues and redistribution with development. J Neurosci. 2014;268:1–9. https://doi.org/10.1016/j.neuroscience.2014.02.042
• 6. Stumpf W, O’Brien LJH. 1,25 (OH)2 vitamin D 3 sites of action in the brain. Histochemistry. 1987;87(5):393–406. https://doi.org/10.1007/BF00496810
• 7. Gao Q, Kou T, Zhuang B, Ren Y, Dong X, Wang Q. The association between Vitamin D deficiency and sleep disorders: A systematic review and meta-analysis. Nutrients. 2018;10(10):1395. https://doi.org/10.3390/nu10101395
• 8. Gominak SC, Stumpf WE. The world epidemic of sleep disorders is linked to vitamin D deficiency. Med Hypotheses. 2012;79(2):132–135. https://doi.org/10.1016/j.mehy.2012.03.031
• 9. Majid MS, Ahmad HS, Bizhan H, Hosein HZM, Mohammad A. The effect of vitamin D supplement on the score and quality of sleep in 20–50 year-old people with sleep disorders compared with control group. Nutr Neurosci. 2018;21(7):511–519. https://doi.org/10.1080/1028415X.2017.1317395
• 10. Huang W, Shah S, Long Q, Crankshaw AK, Tangpricha V. Improvement of pain, sleep, and quality of life in chronic pain patients with vitamin D supplementation. Clin J Pain. 2013;29(4):341–347. https://doi.org/10.1097/AJP.0b013e318255655d
• 11. Kling RN, McLeod CB, Koehoorn M. Sleep problems and workplace injuries in Canada. Sleep. 2010;33(5):611–618. https://doi.org/10.1093/sleep/33.5.611
• 12. Rosekind MR, Gregory KB, Mallis MM, Brandt SL, Seal B, Lerner D. The cost of poor sleep: workplace productivity loss and associated costs. J Occup Environ Med. 2010;52(1):91–98. https://doi.org/10.1097/JOM.0b013e3181c78c30
• 13. Olivieri M, Biscardo CA, Valenza D, Verlato G. Night shift, vitamin D and occupational allergies in bakers. Eur Respir J. 2014;44(Suppl 58):4539.
• 14. Jeong H, Hong S, Heo Y, et al.. Vitamin D status and associated occupational factors in Korean wage workers: data from the 5th Korea national health and nutrition examination survey (KNHANES 2010–2012). Ann Occup Environ Med. 2014;26(1):28. https://doi.org/10.1186/s40557-014-0028-x
• 15. Alefishat E, Farha RA. Determinants of vitamin D status among Jordanian employees: focus on the night shift effect. Int J Occup Med Environ Health. 2016;29(5):859–870. https://doi.org/10.13075/ijomeh.1896.00657
• 16. Park H, Suh B, Lee SJ. Shift work and depressive symptoms: the mediating effect of vitamin D and sleep quality. Chronobiol Int. 2019;36(5):689–697. https://doi.org/10.1080/07420528.2019.1585367
• 17. Cashman KD, van den Heuvel EG, Schoemaker RJ, Prévéraud DP, Macdonald HM, Arcot J. 25-Hydroxyvitamin D as a biomarker of vitamin D status and its modeling to inform strategies for prevention of vitamin D deficiency within the population. Adv Nutr. 2017;8(6):947–957. https://doi.org/10.3945/an.117.015578
• 18. WHO Scientific Group on the Prevention and Management of Osteoporosis.. Prevention and management of osteoporosis: report of a WHO scientific group(WHO technical report series; 921)GenevaWorld Health Organization, 2000.
• 19. Bikle DD. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol. 2014;21(3):319–329. https://doi.org/10.1016/j.chembiol.2013.12.016
• 20. Yu A, Kim J, Kwon O, Oh S-y, Kim J, Yang YJ. Associations between serum 25-hydroxyvitamin D and consumption frequencies of vitamin D rich foods in Korean adults and older adults. Korean J Community Nutr. 2014;19(2):122–132. https://doi.org/10.5720/kjcn.2014.19.2.122
• 21. Nah EH, Kim S, Cho H-I. Vitamin D levels and prevalence of vitamin D deficiency associated with sex, age, region, and season in Koreans. Lab Med Online. 2015;5(2):84–91. https://doi.org/10.3343/lmo.2015.5.2.84
• 22. Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28(2):193–213. https://doi.org/10.1016/0165-1781(89)90047-4
• 23. Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991;14(6):540–545. https://doi.org/10.1093/sleep/14.6.540
• 24. Horne JA, Östberg O. A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. Int J Chronobiol. 1976;4(2):97–110.
• 25. Bjelland I, Dahl AA, Haug TT, Neckelmann D. The validity of the Hospital Anxiety and Depression Scale: an updated literature review. J Psychosom Res. 2002;52(2):69–77. https://doi.org/10.1016/S0022-3999(01)00296-3
• 26. Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD. The fatigue severity scale: application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol. 1989;46(10):1121–1123. https://doi.org/10.1001/archneur.1989.00520460115022
• 27. Connor KM, Davidson JR. Development of a new resilience scale: The Connor‐Davidson resilience scale (CD‐RISC). Depress Anxiety. 2003;18(2):76–82. https://doi.org/10.1002/da.10113
• 28. Group TW. The World Health Organization quality of life assessment (WHOQOL): development and general psychometric properties. Soc Sci Med. 1998;46(12):1569–1585. https://doi.org/10.1016/S0277-9536(98)00009-4
• 29. Silva PAB, Soares SM, Santos JFG, Silva LB. Cut-off point for WHOQOL-bref as a measure of quality of life of older adults. Rev Saude Publica. 2014;48(3):390–397. https://doi.org/10.1590/S0034-8910.2014048004912
• 30. Silva SM, Santana ANC, Silva NNBd, Novaes MRCG. VES-13 and WHOQOL-bref cutoff points to detect quality of life in older adults in primary health care. Rev. Saude Publica. 2019;53:26. https://doi.org/10.11606/S1518-8787.2019053000802
• 31. Schutte-Rodin S, Broch L, Buysse D, Dorsey C, Sateia M. Clinical guideline for the evaluation and management of chronic insomnia in adults. J Clin Sleep Med. 2008;4(5):487–504. https://doi.org/10.5664/jcsm.27286
• 32. Åkerstedt T. Shift work and disturbed sleep/wakefulness. Occup Med (Lond.). 2003;53(2):89–94. https://doi.org/10.1093/occmed/kqg046
• 33. Araújo JF. The impact of different shift work schedules on the levels of anxiety and stress in workers in a petrochemicals company. Estud Psicol Campinas. 2009;26(1):15–23. https://doi.org/10.1590/S0103-166X2009000100002
• 34. Shen J, Botly LC, Chung SA, Gibbs AL, Sabanadzovic S, Shapiro CM. Fatigue and shift work. J Sleep Res. 2006;15(1):1–5. https://doi.org/10.1111/j.1365-2869.2006.00493.x
• 35. Kim YG, Yoon DY, Kim JI, et al.. Effects of health on shift-work: general and psychological health, sleep, stress, quality of life. Korean J Occup Environ Med. 2002;14(3):247–256. https://doi.org/10.35371/kjoem.2002.14.3.247
• 36. Costa G. Shift work and health: current problems and preventive actions. Saf. Health Work. 2010;1(2):112–123. https://doi.org/10.5491/SHAW.2010.1.2.112
• 37. Itoh H, Weng Z, Saito H, et al.. Association between night-shift work and serum 25-hydroxyvitamin D levels in Japanese male indoor workers: a cross-sectional study. Ind Health. 2011;49(5):658–662.
• 38. Nakamura K, Nashimoto M, Matsuyama S, Yamamoto MJN. Low serum concentrations of 25-hydroxyvitamin D in young adult Japanese women: a cross sectional study. Nutrition. 2001;17(11-12):921–925. https://doi.org/10.1016/S0899-9007(01)00662-1
• 39. Masood T, Kushwaha RS, Singh R, et al.. Circadian rhythm of serum 25 (OH) vitamin D, calcium and phosphorus levels in the treatment and management of type-2 diabetic patients. Drug Discov Ther. 2015;9(1):70–74. https://doi.org/10.5582/ddt.2015.01002
• 40. Jones KS, Redmond J, Fulford AJ, et al.. Diurnal rhythms of vitamin D binding protein and total and free vitamin D metabolites. J Steroid Biochem Mol Biol. 2017;172:130–135. https://doi.org/10.1016/j.jsbmb.2017.07.015
• 41. McCarty DE, Reddy A, Keigley Q, Kim PY, Marino AA. Vitamin D, race, and excessive daytime sleepiness. J Clin Sleep Med. 2012;8(6):693–697. https://doi.org/10.5664/jcsm.2266
• 42. Beydoun MA, Gamaldo AA, Canas JA, et al.. Serum nutritional biomarkers and their associations with sleep among US adults in recent national surveys. PLoS One. 2014;9(8):e103490. https://doi.org/10.1371/journal.pone.0103490
• 43. McCarty DE. Resolution of hypersomnia following identification and treatment of vitamin D deficiency. J Clin Sleep Med. 2010;6(6):605–608. https://doi.org/10.5664/jcsm.27996
• 44. Johnson K, Sattari M. Vitamin D deficiency and fatigue: an unusual presentation. Springerplus. 2015;4(1):584. https://doi.org/10.1186/s40064-015-1376-x
• 45. Peterson CA, Heffernan ME. Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25 (OH) D concentrations in healthy women. J Inflamm (Lond). 2008;5(1):10. https://doi.org/10.1186/1476-9255-5-10
• 46. Jablonski KL, Chonchol M, Pierce GL, Walker AE, Seals DR. 25-Hydroxyvitamin D deficiency is associated with inflammation-linked vascular endothelial dysfunction in middle-aged and older adults. Hypertension. 2011;57(1):63–69. https://doi.org/10.1161/HYPERTENSIONAHA.110.160929
• 47. Massa J, Stone KL, Wei EK, et al.. Vitamin D and actigraphic sleep outcomes in older community-dwelling men: the MrOS sleep study. Sleep. 2015;38(2):251–257. https://doi.org/10.5665/sleep.4408
• 48. Mirzaei A, Zabihiyeganeh M, Jahed SA, Khiabani E, Nojomi M, Ghaffari S. Effects of vitamin D optimization on quality of life of patients with fibromyalgia: A randomized controlled trial. Med J Islam Repub Iran. 2018;32(1):167–172. https://doi.org/10.14196/mjiri.32.29
• 49. McCann JC, Ames BN. Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction? FASEB J. 2008;22(4):982–1001. https://doi.org/10.1096/fj.07-9326rev
• 50. Hoffmann MR, Senior PA, Mager DR. Vitamin D supplementation and health-related quality of life: a systematic review of the literature. J Acad Nutr Diet. 2015;115(3):406–418. https://doi.org/10.1016/j.jand.2014.10.023

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