Vitamin D Deficiency and Electrocardiographic Subclinical Myocardial Injury: Results from National Health and Nutrition Examination Survey‐III
Clinical Cardiology, https://doi.org/10.1002/clc.23078
Muhammad Imtiaz Ahmad MBBS Parag Anilkumar Chevli MBBS Yabing Li MD Elsayed Z. Soliman MD, MSc, MS
Cardiovascular category starts with the following
Cardiovascular category is associated with other categories: Diabetes 31, Omega-3 31 , Vitamin K 25 , Intervention 22 . Mortality 20 , Skin - Dark 18 , Magnesium 17 , Calcium 14 , Hypertension 14 , Trauma and surgery 13 , Stroke 13 , Kidney 12 , Metabolic Syndrome 11 , Seniors 10 , Pregnancy 8 as of Aug 2022
- Overview Cardiovascular and vitamin D
- Cardiovascular Disease is treated by Vitamin D - many studies 39+ meta-analyses
- Coronary Artery Disease and Vitamin D - many studies 18+
- Cardiovascular problems reduced by Omega-3 - many studies 34+
- Arteries and Atherosclerosis and Vitamin D - many studies 71+
- Atrial Fibrillation decreased by Vitamin D or Magnesium - many studies 26+
- Statins and Vitamin D - many studies 25+
- Arterial Stiffness and Vitamins – only Vitamin D was found to help – meta-analysis Feb 2022
- Those raising Vitamin D above 30 ng were 1.4 X less likely to die of Heart Attack (VA 19 years) – Oct 2021
- Giving free vitamin D to every Iranian would pay for itself by just reducing CVD – Oct 2021
- Sudden Cardiac Arrest – 2.8 X higher risk if low vitamin D – 2019
- Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis March 2018
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
- Cardiovascular disease 2.3 X more-likely if poor Vitamin D Receptor – Aug 2022
Cholesterol, Statins
- Cholesterol is needed to produce both Vitamin D and Cortisol
- Overview Cholesterol and vitamin D
- Statins and Vitamin D - many studies statins often reduce levels of vitamin D
- Statin side-effects are reduced by Vitamin D – US patent Application – April 2019
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Objective
Association of cardiovascular disease (CVD) with non‐traditional risk factors such as vitamin D deficiency has been examined previously. An investigation of the association of vitamin D with subclinical myocardial injury (SC‐MI) based on an electrocardiographic score is a simple, cost‐effective and innovative way to explore this relationship.
Methods
This analysis included 6079 participants (58.3±13.1 years; 54.1% women) without CVD from NHANES III. A multivariable logistic regression model was used to examine the association between vitamin D categories (<20 ng/ml, 20‐29 ng/ml and >30 ng/ml(reference) and cardiac injury score (CIIS).
Results
There was an incremental increase in the prevalence of SC‐MI across vitamin D categories with the highest prevalence in <20 ng/ml, followed by 20‐29 ng/ml and then >30 ng/ml (trend p‐value <.0001). There was a statistically significant association between vitamin D deficiency (<20 ng/ml) and SC‐MI (OR(95%CI): 1.27(1.04‐1.55), p = 0.04). This association was stronger in men than women (OR(95%CI): 1.74(1.32‐2.30) vs. 0.94(0.70‐1.25) respectively; interaction p‐value 0.002).
Conclusions
Vitamin D deficiency is associated with SC‐MI, especially in men. These findings may further highlight the role of non‐traditional risk factors in the development of CVD. The value of vitamin D supplementation in the prevention of myocardial ischemia and injury may warrant investigation.
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