Hip fractures requiring hospitalization cut in half by Vitamin K1 (100 mcg per day) – Sept 2022

Dietary Vitamin K1 intake is associated with lower long-term fracture-related hospitalization risk: the Perth longitudinal study of ageing women†

Food & Function DOI https://doi.org/10.1039/D2FO02494B
Marc Sim, ‡*abc Andre Strydom,‡b Lauren C. Blekkenhorst,abc Nicola P. Bondonno, Rachel McCormick,a Wai H. Lim,be Kun Zhu,bf Elizabeth Byrnes,g Jonathan M. Hodgson,abc Joshua R. Lewis abch and Richard L. Prince abi

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This study examined the association between dietary Vitamin K1 intake with fracture-related hospitalizations over 14.5 years in community-dwelling older Australian women (n = 1373, =70 years). Dietary Vitamin K1 intake at baseline (1998) was estimated using a validated food frequency questionnaire and a new Australian Vitamin K nutrient database, which was supplemented with published data. Over 14.5 years, any fracture (n = 404, 28.3%) and hip fracture (n = 153, 10.7%) related hospitalizations were captured using linked health data. Plasma Vitamin D status (25OHD) and the ratio of undercarboxylated osteocalcin (ucOC) to total osteocalcin (tOC) from serum was assessed at baseline. Estimates of dietary Vitamin K1 intake were supported by a significant inverse association with ucOC : tOC; a marker of Vitamin K status (r = -0.12, p < 0.001).
Compared to women with the lowest Vitamin K1 intake (Quartile 1, <61 µg d-1), women with the highest Vitamin K1 intake (Quartile 4, =99 µg d-1) had lower hazards for

• any fracture- (HR 0.69 95%CI 0.52–0.91, p < 0.001) and
• hip fracture-related hospitalization (HR 0.51 95%CI 0.32–0.79, p < 0.001),

independent of 25OHD levels, as part of multivariable-adjusted analysis.
Spline analysis suggested a nadir in the relative hazard for any fracture-related hospitalizations at a Vitamin K1 intake of approximately 100 µg day-1. For hip fractures, a similar relationship was apparent. Higher dietary Vitamin K1 is associated with lower long-term risk for any fracture- and hip fracture-related hospitalizations in community-dwelling older women.

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VitaminDWiki - Overview Vitamin K and Vitamin D contains

Vitamin K2 is similar to D3 in many ways

1. Both vitamins were initially confused with its lesser form (D2 ==> D3, K1 ==> K2)
2. Both vitamins appear to influence health in large number of ways
3. Both vitamins in the body are about 1/10 that of a century ago
   Example: Grass-fed beef has a lot more K2, D3, and Magnesium
4. Need very little of both vitamins: <1 milligram daily
5. When Vitamin D3 is increased, it appears that Vitamin K2 should also be increased
6. Vitamin K2 understanding and research is about 20 years behind that of Vitamin D3
   One of the reasons: [https://www.perplexity.ai/search/is-there-a-vitamin-k2-blood-te-vVTdLPwcTFyi1Z_PM8yvTw|No simple blood test for K2 as of Dec 2024]

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VitaminDWiki - 9 studies in both categories Vitamin K and Falls/Fractures

This list is automatically updated

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68+ VitaminDWiki pages with HIP FRACTURE in title

This list is automatically updated