By Perplexity AI June 2024
The Vitamin D Receptor (VDR) affects the expression and regulation of numerous genes across the genome. Here are some key genes and gene families influenced by VDR:
- CYP24A1: This gene encodes the enzyme responsible for vitamin D catabolism. VDR strongly upregulates CYP24A1 expression as part of a negative feedback loop to control vitamin D levels.
- CAMP (Cathelicidin Antimicrobial Peptide): VDR induces expression of this gene, which plays a crucial role in innate immunity and antimicrobial defense.
- Calcium transport genes: VDR regulates genes involved in calcium homeostasis, including calcium-binding proteins like calbindin, CALB1 and calcium channel proteins.
- Bone metabolism genes: VDR influences genes involved in bone formation and resorption, such as osteocalcin (BGLAP) and osteopontin (SPP1).
- Cell cycle regulators: VDR can modulate the expression of genes involved in cell proliferation and differentiation, including p21 and p27.
- Immune system genes: VDR affects various genes involved in immune function, including cytokines and their receptors.
- Renin-angiotensin system genes: VDR has been shown to regulate renin gene expression, influencing blood pressure control.
- Detoxification genes: VDR regulates genes involved in xenobiotic metabolism, such as CYP3A4.
- Epigenetic modifiers: VDR can influence the expression of genes involved in epigenetic regulation, potentially affecting a wide range of cellular processes.
- Tumor suppressor genes: In some contexts, VDR can regulate genes involved in cancer prevention and progression.
It's important to note that the specific genes affected by VDR can vary depending on cell type, tissue context, and physiological conditions.
The VDR is estimated to regulate about 3-5% of the human genome, potentially influencing thousands of genes directly or indirectly.
The complex interplay between VDR, its target genes, and various environmental and genetic factors contributes to the wide-ranging effects of vitamin D in the body
Perplexity provides many references
VitaminDWiki – Vitamin D Receptor contains
Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
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The Vitamin D Receptor is associated with many health problems
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation
55 health problems associated with poor VDR
A poor VDR is associated with the risk of 55 health problems click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023 click here for details
Some health problem, such as Breast Cancer reduce the VDR
VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
How to increase VDR activation
Compensate for poor VDR by increasing one or more:
| Increasing | Increases |
| 1) Vitamin D supplement Sun Ultraviolet -B | Vitamin D in the blood and thus in the cells |
| 2) Magnesium | Vitamin D in the blood AND in the cells |
| 3) Omega-3 | Vitamin D in the cells |
| 4) Resveratrol | Vitamin D Receptor |
| 5) Intense exercise | Vitamin D Receptor |
| 6) Get prescription for VDR activator paricalcitol, maxacalcitol? | Vitamin D Receptor |
| 7) Quercetin (flavonoid) | Vitamin D Receptor |
| 8) Zinc is in the VDR | Vitamin D Receptor |
| 9) Boron | Vitamin D Receptor ?, etc |
| 10) Essential oils e.g. ginger, curcumin | Vitamin D Receptor |
| 11) Progesterone | Vitamin D Receptor |
| 12) Infrequent high concentration Vitamin D Increases the concentration gradient | Vitamin D Receptor |
| 13) Sulfroaphane and perhaps sulfur | Vitamin D Receptor |
| 14) Butyrate especially gut | Vitamin D Receptor |
| 15) Berberine | Vitamin D Receptor |
Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
Increased risk of diseases if poor VDR
Increased risk associated with a poor Vitamin D Receptor
Note: Some diseases reduce VDR activation
those with a * are known to decrease activation
VitaminDWiki – Genetics category contains
see also
- Vitamin D Receptor has
530 items - Vitamin D Binding Protein = GC has
178 items - CYP27B1 has
63 items - CYP24A1 in title of 39+ items
- CYP2R1 25+ items
- Calcidiol has
48 items - Calcitriol has
62 items - Topical Vitamin D
- Nanoemulsion Vitamin D may be a substantially better form
- 1289 genes changed with higher doses of Vitamin D - RCT Dec 2019
- CYP3A4 (7 as of Dec 2022)
- Getting Vitamin D into your body
Vitamin D blood test misses a lot
- Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
- Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
- A Vitamin D test in cells rather than blood was feasible (2017 personal communication) Commercially available 2019
- However, test results would vary in each tissue due to multiple genes
- Good clues that Vitamin D is being restricted from getting to the cells
1) A vitamin D-related health problem runs in the family
especially if it is one of 51+ diseases related to Vitamin D Receptor
2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase)
3) DNA and VDR tests - 100 to 200 dollars $100 to $250
4) PTH bottoms out ( shows that parathyroid cells are getting Vitamin d)
Genes are good, have enough Magnesium, etc.
5) Back Pain
probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc- The founder of VitaminDWiki took action with clues #3&5
Vitamin D Receptor affects 10 other genes - June 2024(Cached) Printer Friendly Follow this page for updates1845 visitors, last modified 21 Sep, 2024, This page is in the following categories (# of items in each category) - Vitamin D Binding Protein = GC has