Autoimmunity problems often associated with poor Vitamin D Receptors – March 2019

Immunological effects of vitamin D and their relations to autoimmunity

Journal of Autoimmunity https://doi.Org/10.1016/j.jaut.2019.03.002

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Erin Yamamoto a, Trine N. J0rgensen b’ jorgent at ccf.org
a Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, 44195, USA
b Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44106, USA

Vitamin D deficiency is an established risk factor for many autoimmune diseases and the anti-inflammatory properties of vitamin D underscore its potential therapeutic value for these diseases. However, results of vitamin D3 supplementation clinical trials have been varied. To understand the clinical heterogeneity, we reviewed the pre-clinical data on vitamin D activity in four common autoimmune diseases:

• multiple sclerosis (MS),
• rheumatoid arthritis (RA),
• systemic lupus erythematosus (SLE), and
• inflammatory bowel disease (IBD),

in which patients are commonly maintained on oral vitamin D3 supplementation. In contrast, many pre-clinical studies utilize other methods of manipulation (i.e. genetic, injection). Given the many actions of vitamin D3 and data supporting a vitamin D-independent role of the Vitamin D receptor (VDR), a more detailed mechanistic understanding of vitamin D3 activity is needed to properly translate pre-clinical findings into the clinic. Therefore, we assessed studies based on route of vitamin D3 administration, and identified where discrepancies in results exist and where more research is needed to establish the benefit of vitamin D supplementation.