- Narrative by Satya L. Nahu, MD ( from GrassrootsHealth)
- Q and A with Dr. Nahu
- VitaminDWiki – Overview MS and vitamin D contains
- VitaminDWiki – Multiple Sclerosis and (lots of) Vitamin D - book by patient on Coimbra protocol - Feb 2016 contains protocol description
- VitaminDWiki –Multiple Sclerosis and (lots of) Vitamin D - book by patient on Coimbra protocol - Feb 2016 contains Facebook Groups
- Facebook pages on Vitamin D and Multiple Sclerosis (original list)
- Facebook groups and pages related to Coimbra vitamin D protocol: (list added Jan 2017)
- Some Facebook pages on just Vitamin D
- VitaminDWiki – Multiple Sclerosis 32 percent less likely among those with more than 32 ng of vitamin D – Dec 2019
- VitaminDWiki – Comparing High-dose vitamin D therapies
- VitaminDWiki – Can get 50,000 IU Vitamin D anywhere on the globe
- It appears that less D is needed if one adds any of 14 activators of the Vitamin D Receptor
Narrative by Satya L. Nahu, MD ( from GrassrootsHealth)
My story with Vitamin D began in 2012, at the time of my Multiple Sclerosis diagnosis. I was 31, and already a doctor as I had just finished my second specialization (Cardiology) a few months prior. It was suddenly and without warning that I woke up with intense tingling in both hands, which spread up both arms in addition to the sensation of shocks in the spine when flexing the neck. Fatigue, days later, was associated with the condition. Around 30 days after symptoms began, the diagnosis was made, through the addition of magnetic resonance imaging of my entire central nervous system (brain and spinal cord), collection of cerebrospinal fluid and blood laboratory tests.
The feeling of life “cut off,” after so much effort to be a doctor, to specialize, to dedicate yourself, and now what would be waiting for me soon would be sick pay, wheelchairs, and early retirement due to disability… I stayed exactly 1 month after the diagnosis in the revolt and thinking about the “injustice” that had happened. Later, I would be mature enough to understand that nothing happens by chance.
Conventional medications were started (corticoid in the form of pulse therapy and immunomodulators such as Interferon beta-1b). However, they did not have the desired effect and I was increasingly fatigued, and the symptoms were trying to spread. A few months later, I started to develop arthritis in my knees and wrists, dry mouth and eyes, and markers that were previously negative started to become positive for another autoimmune disease called Sjogren’s Syndrome.
Faced with the association of diseases and failures in therapeutic responses, my family and friends began to look for other forms of treatment and information was seen on the internet about vitamin D and autoimmune disease, more precisely about multiple sclerosis. There were videos and testimonials about the use of vitamin D in higher doses, and they were exciting to see – people returning to have a fully normalized and compensated life, literally leaving the autoimmune nightmare. However, I declined and did not go ahead, because I thought it would be a fantasy, that “a vitamin that is linked to making strong bones was able to cure people of autoimmune diseases,” and when asked, my doctor said that it had no basis, and that this experimental treatment was dangerous.
I could have dug deeper, studied about it, learned more about this innovative doctor named Dr. Cicero Galli Coimbra who taught about the vitamin D treatment, but when I was sick and even more so as a doctor, there was a fear of going against my colleagues, against the traditional establishment, and even of being branded as irresponsible, so I decided that it was not for me and I put it aside.
Interestingly, my conventional neurologist ended up prescribing a dose of 10,000 IU of vitamin D per day, at the time according to him, the maximum dose accepted by traditional societies, but my vitamin D level didn’t even reach 50 ng/ml (125 nmol/L) and in fact I didn’t see any difference in my symptoms. I worked on other aspects of my life; I improved my diet, removed inflammatory foods (dairy, gluten, sugars, etc.), did regular physical activity, started receiving Acupuncture, reorganized my work routine, among other interventions. The autoimmune system calmed down, but was still touchy… the slightest stress, for example, was enough to activate the arthritis, have parotitis, dry eyes, increase numbness in the hands and reactivate fatigue, etc.. And so I lived until 2017 when I found myself again with vitamin D in a lecture by another neurologist who had undergone high dose vitamin D training with Dr. Cicero Coimbra. Then began my second chance to turn life around.
The information acquired in this explanation made a lot of sense to me, and it was then that I decided to make an appointment with this doctor. When he referred to the PubMed website and entered the words in English in the search field: multiple sclerosis; vitamin d polymorphism; VDR, several articles came out that reached the same conclusions about the existence of genetic defects linked to vitamin D that were linked to autoimmune diseases, specifically multiple sclerosis.
At that moment, the stories of success that I had heard of years ago and the foundation of why it works began to make total scientific sense. I was impressed by the extent to which countless scientists were already working on this and not a word was seen in congresses, symposiums, colleges about the promise of vitamin D and its non-calcemic effects… And it was evident that if you could not patent vitamin D and make a “medicine” of this substance and profit millions or even billions of dollars in isolation due to patent law, it was clear why there was prejudice and lack of information.
I learned that individuals with certain autoimmune diseases carry genetic polymorphisms of vitamin D, such as VDR receptor, vitamin D binding protein (Gc-globulin) and hydroxylase enzymes (vitamin D 1a-hydroxylase -CYP1a- is one of them). These genetic defects when activated help trigger an autoimmune response, as one of the many functions of vitamin D when it is in perfect working order is to modulate the response of Th17 cells, which are the main cells that attack our body when they are in disorder during an autoimmune condition. He proposed a treatment, called the “Coimbra Protocol” developed by Dr. Cicero Galli Coimbra, neurologist, Ph.D. director of the laboratory of Neuropathology and Neuroprotection at UNIFESP (Federal University of Sao Paulo), also an Associate Professor at the same institution, which aims at the use of high doses of vitamin D for correction and compensation of genetic resistance to the effects of vitamin D in patients with autoimmune diseases. It was then that I underwent the treatment and in 45 days my arthritis and fatigue disappeared as well as the dryness of the eyes and mouth, and over the course of months, the numbness. After my experience, I applied for the internship to be trained by Dr himself Cicero (there are more than 100 Brazilian and foreign doctors personally trained by him) and learned how to handle the high dose of vitamin D with my future autoimmune patients. I went to Sao Paulo -SP in 2018 and it was unforgettable… they were days of intense and profound learning. How much groundbreaking scientific knowledge, infinite courage and generosity Dr. Cicero Galli Coimbra had. Those days spent in his office, caring for patients together with other medical colleagues and seeing the results, were the practical basis for understanding how this extraordinary treatment, affectionately called by his patients the “Coimbra Protocol”, was one of the most remarkable moments of my life. Today this treatment has saved thousands of lives here in Brazil and abroad. It is even spoken in 13 languages and has more than 150 doctors trained worldwide. We see ex-wheelchair patients, patients mistreated by autoimmune and side effects of immunobiological and immunosuppressants, who suffered from crucial and debilitating arthritis, disfiguring skin lesions, endless fatigue just to name a few, and seeing their evolution with the treatment was a unique and surreal experience.
I was falling in love with medicine again and living what I always wanted to live. Treating the disease for its CAUSES was central… the enormous therapeutic potential of correcting the level of vitamin D to normal values (within the range of normality) and more optimized provides the general population with the most varied benefits… from being free of flu, colds and other respiratory infections so common in the general population, to a safer pregnancy, with a reduction in pre-eclampsia, gestational diabetes, control and remission of immune disorders, such as asthma, rhinitis and dermatitis, as well as other conditions such as hypertension, diabetes mellitus, depression, anxiety, just to name a few… to avoiding more adverse effects of the COVID-19 disease and its complications. Countless studies have now shown these effects. I worked during all these “pandemic years” on the frontline (emergency care) and I have no doubt that having an immunity adjusted and proportional to my needs was decisive for having the shielding immune system needed to fight this challenging and pathogenic virus.
The ubiquity of vitamin D is impressive and astounding. Knowing that we are living in an era of solar phobia and the profound lack of dissemination of information among doctors themselves who mainly feed on information coming from the pharmaceutical industry is suffocating and bordering on naivety. Yes, I was also part of the large group of naive listeners.
This protocol was started in 2002 and has been improved over time until it returned thousands of patients worldwide to remission in autoimmune diseases safely and without unpredictable adverse effects. However, high doses of cholecalciferol without having the “contra -balance” are harmful because they provide hypercalcemia. To avoid this undesired effect, we recommend that the patient regularly hydrate with an intake of at least 2.5 liters per day (depending on weight) and follow a diet low in foods rich in calcium. The adjustment of dosages and the control of side effects are done through mandatory medical monitoring, associated with blood and urine tests essential for the correction and optimization of the treatment.
There are scientific studies that support the safety and efficacy of using high doses of vitamin D3, including one with the participation of emeritus Dr. Michael Holick, one of the greatest vitamin D researchers of all time. Some interesting scientific references on the use of high doses of vitamin D3 in patients with autoimmune diseases:
A pilot study assessing the effect of prolonged administration of high daily doses of vitamin D on the clinical course of vitiligo and psoriasis https://pubmed.ncbi.nlm.nih.gov/24494059/
Safety Data in Patients with Autoimmune Diseases during Treatment with High Doses of Vitamin D3 According to the “Coimbra Protocol” hcps://pubmed.ncbi.nlm.nih.gov/35458137/
Vitamin D Resistance as a Possible Cause of Autoimmune Diseases: A Hypothesis Confirmed by a Therapeutic High-Dose Vitamin D Protocol https://pubmed.ncbi.nlm.nih.gov/33897704/
Myasthenia Gravis in Pregnancy Treated With Daily Massive Vitamin D Dose
https://asploro.com/myasthenia-gravis-in-pregnancy-treated-with-daily-massive-vitamin-d-dose/
Refractory immune thrombocytopenia successfully treated with high-dose vitamin D supplementation and hydroxychloroquine: two case reports hcps://jmedicalcasereports.biomedcentral.com/articles/10.1186/1752-1947-7-91
Remission of Severe Myasthenia Gravis After Massive-Dose Vitamin D Treatment //www.ncbi.nlm.nih.gov/pmc/articles/PMC4734680/
Daily oral vitamin D3 without concomitant therapy in the management of psoriasis: A case series
https://www.sciencedirect.com/science/article/pii/S2772613422000014?via%3Dihub
High dose vitamin D supplementation in Rheumatoid Arthritis patients hcps://www.hra.nhs.uk/planning-and-improving-research/application-summaries/researchsummaries/high-dose-vitamin-d-supplementa?on-in-rheumatoid-arthritis-patients/
Upon my return to my city, after my immersion in new knowledge that very few people in the world of doctors possessed, I realized that my life had not only taken a definitive and different course in terms of autoimmune disease, but a path of no return…from that moment on, my whole way of seeing and experiencing medicine had changed at its roots and a window of opportunity had opened to create a new way of treating, focused on the causes and not just the consequences. With that, I would have the opportunity to support myself, family, friends and patients with a safe, sustained and definitive health status.
Best regards,
Satya L. Nahu, MD
*It is essential that individuals do not try to “self-treat” with this protocol. The specific treatment is tailored to each patient based on monitoring that includes several periodic lab tests and adjustments in dosing.
Q and A with Dr. Nahu
How much vitamin D do you take? How do you get it (sun or supplements)?
I take 150,000 IU/day.
Through capsules that carry vitamin D in its liquid form, (“liquid-caps”) similar to the well-known softgel. Each capsule contains 50,000 IU.
Through the sun it would be impossible to obtain this daily amount.
What is your vitamin D level now and what is your goal?
495 ng/ml (four hundred and ninety-five)
Maintaining my PTH at values close to the lower limit, with completely normal calcium and renal function (as it has always been since I started treatment).
What was your vitamin D level when you first tested it?
43 ng/ml (without supplement)
What other supplements do you take and/or dietary changes have you made to support your vitamin D status and overall health?
Supplements:
1-Chelated magnesium 4x a day (the higher the levels of Vitamin D3, the greater the need for magnesium).
2-Polyvitaminic (Containing zinc, vitamin A, B12, B9, P-5-P, Chromium, Silicon chelate among others)
3-Omega 3
4-Green Propolis
The above refers to the treatment of the Coimbra Protocol, in addition to Vitamin D3.
The ones I would call extras, also used by me, would be Melatonin and Probiotics.
Diet
Diet that excludes foods rich in calcium, including dairy products and all their derivatives. Some tropical fruits that contain large amounts of calcium, green leaves in cooked form, oilseeds are some of the other foods that are also on the list of prohibited foods for patients who use high doses of vitamin D3.
Hydration:
I ingest 3,000 ml / day. We calculate Weight (kg) x 40 ml to know the average amount of liquid to be ingested. In my case, it would be around 2,600 ml, which I rounded up to 3,000 ml because I live in a place that is usually hot (tropical region).
What would you recommend to others who are in a similar situation?
Test your vitamin D3 and try to have blood levels of at least 60 ng/ml if you don’t have a professional looking after your health in this regard.
Look for health professionals who are committed to a more integrative and functional view of the human being.
Find out about ways you can get smart exposure to the sun.
Have more contact with nature whenever possible.
Hydrate properly
Eat in a varied way, avoid food monotony and industrialized foods as much as possible in your daily life.
Take care of your mental health. The illness process begins with situations that trigger anger, sadness, anxiety and fear, for acute or chronic periods that lead to awakening our bad genes (dirty genes).
Accept yourself, love yourself, forgive yourself, be nice to yourself and always be grateful for all the gifts in life!
VitaminDWiki – Overview MS and vitamin D contains
Clinical interventions have shown that Vitamin D can prevent, treat, and even cure Multiple Sclerosis, at a tiny fraction of the cost of the drugs now used to treat it, and without side effects.
- Fact: Low Vitamin D results in higher risk of getting MS
Increase latitude leads to decreased Vitamin D, which leads to increased risk of MS
Dark skinned people are far more likely to get MS (dark skin people typically have low vitamin D)
Elderly (who typically have low vitamin D) are more likely to get MS
Is there increased risk in people who already have diseases associated with low vitamin D - TB, for example ? ? ?
Women typically have 3X increased MS risk then men (note: women typically have 20% lower levels of vitamin D than men)
Exception: women in very sunny climates and dark-skinned women have the same MS risk as men
Obese are 60% more likely to get MS
Multiple Sclerosis 42X more likely if light brown skin and smoke (both associated with low vitamin D) – July 2020
MS recurrence is much higher in spring - the lowest time of the year for vitamin D
increase in clouds/rainfall (which reduces available Vitamin D) is associated with increased risk of MS (Scotland, Western Washington)
MS incidence has increased 70% in a decade while the incidence of vitamin D deficiency doubled
Less MS in those with outdoor occupations PDF file, not a web page - Fact: MS uses up Vitamin D
- Fact: Lower vitamin D (due to MS using up Vitamin D while fighting the disease) results in many other health problems (such as broken bones), so depleted vitamin D levels must be restored.
- Fact: Vitamin D looks so promising for preventing and treating MS that there were 25 INTERVENTION clinical trials as of Feb 2014
- Fact: Vitamin D reduced the MS relapse rate far better than Fingolimod which is now used for that purpose.
- Note: Fingolimod costs $25,000/year while vitamin D, which works better and has no side effects is 1000 times less expensive.
- Fact: 98% of the genes affected by Interferon are also affected by Vitamin D
- Note: 1 week of Interferon = $4,700, 1 week of vitamin D 10,000X lower cost
- Fact: MS Doctors in Brazil recommending 40-100 ng/mL of Vitamin D
- Fact: Many MS forums are recommending vitamin D to treat MS, with some taking 5,000 to 10,000 IU daily
Observation: Risk of going from pre-MS to MS reduced 68 percent with 7100 IU vitamin D – RCT Dec 2012- This is an observation instead of a fact - it has not yet been confirmed.
- Fact: VERY LARGE doses of vitamin D have CURED 2,000 people of MS in Brazil
- Controversy: UVB fron sunlight or UVB bulb may be BETTER than Vitamin D for reducing the risk of getting MS
- Hypothesis: In addition to Vitamin D there are many other photoproducts produced by UVB that may promote health.
Summary: lack of consensus on how much to prevent, treat, or cure MS.
- Coimbra Protocol (using Vitamin D) is safe and effective for Multiple Sclerosis and Autoimmune diseases – April 2022
- 54,000 IU of vitamin D daily with no Calcium (1,000 IU per kg: Coimbra protocol) – July 2024
- How much Vitamin D to prevent many diseases - such as MS
- How much Vitamin D is needed to treat MS? There is currently no agreement
The recommendations range from 40 to 100 ng - which can result of a dose ranging from 3,000 to 20,000 IU/day - How Vitamin D is needed to Cure MS?: It appears that 20,000-140,000 IU daily may be needed to CURE the disease
You must be under the supervision of a doctor who knows what to watch for in your individual situation.
High doses of Vitamin D cannot be used as a monotherapy.
You will need to adjust the cofactors: Typically increasing Magnesium and Vitamin K2, and reducing Calcium intake.
Your doctor will monitor these and might increase your intake of Vitamins B2, C, as well as Omega-3 - Epstein-Barr virus increases risk of Multiple Sclerosis by 32X - Jan 2022
- Multiple Sclerosis treated by Vitamin D, recommends investigating high dose Coimbra - Oct 2021
- Multiple Sclerosis patients had fewer COVID-19 problems (Note: many MSers take Vitamin D) – April 30, 2021
- Vitamin D Resistance hypothesis confirmed by Coimbra high-dose vitamin D protocol – April 2021
- Multiple Sclerosis relapses cut in half by 100,000 IU of Vitamin D every 2 weeks– RCT 2019
VitaminDWiki – Multiple Sclerosis and (lots of) Vitamin D - book by patient on Coimbra protocol - Feb 2016 contains protocol description__
Vitamin D Protocol used by Dr. Coimbra for Multiple Sclerosis etc.
Snips as of April 2016 http://www.vitamindprotocol.com/dr.-coimbra-s-ms-protocol.html
- 1,000 IU's vitamin D per kilogram as a first approximation
(apparently increased/decreased depending of resulting vitamin D blood level) - Vitamin B2, magnesium glycinate, boron, chromium picolinate, Omega 3 DHA, Zinc, Methylcobalamin form of B12, Choline, etc.
- Lack of B12 may affect 10%–15% of the general population and may be the most prevalent genetic risk factor for several human diseases
- Discontinue eating or drinking dairy products or calcium enriched foods or beverages, also no Ca supplements
- Drink as least 2.5 liters [85 ounces] of fluids, preferably water
- Required Tests: Vitamin D, Parathyroid, Blood calcium, urinary calcium
VitaminDWiki –Multiple Sclerosis and (lots of) Vitamin D - book by patient on Coimbra protocol - Feb 2016 contains Facebook Groups__
Facebook pages on Vitamin D and Multiple Sclerosis (original list)
- Portuguese - oldest on FB :18,788 members Jan 2017
- MS & Vitamin D - English
- English 965 members Jan 2017, 7,000 members as of May 2018
- Italian 6,570 members as of Jan 2017
- German 2,350 members as of Jan 2017 (started Sept 2016)
Her book and protocol in German under development - perhaps Spring 2017 - Vitamin D Protocol North America 1,449 members Jan 2017
Facebook groups and pages related to Coimbra vitamin D protocol: (list added Jan 2017)
From list on Google Drives not online July 2021
English
- Vitamin D Protocol North America: https://www.facebook.com/groups/vitamindprotocolnorthamerica/
- High-Dose Vitamin D for Autoimmune Diseases: https://www.facebook.com/coimbraprotocol/*fref=nf
- Multiple Sclerosis - Vitamin D: https://www.facebook.com/groups/433972210087009/*fref=ts
- Vitamin D Multiple Sclerosis: https://www.facebook.com/Vitamin-D-Multiple-Sclerosis-156229837877670
- Vitamin D and MS: https://www.facebook.com/groups/vitamindandms 546 members as of Jan 2017
- Vitamin D Deficiency Syndrome (not only regarding autoimmune diseases, but inspired by Coimbra protocol): https://www.facebook.com/groups/120738731293512/*ref=ts&fref=ts
Brazilian/Portuguese
- ESCLEROSE MULTIPLA - O TRATAMENTO: https://www.facebook.com/groups/EscleroseMultiplaOTratamento
- ESCLEROSE MULTIPLA TEM SOLUCAO - BEMDITASVITAMINAS: https://www.facebook.com/groups/190960337581683
- Artrite Reumatoide - Tratamento com VITAMINA D: https://www.facebook.com/groups/1428810010667211
- Vitamina D - Natureza, Nutricao e Saude: https://www.facebook.com/groups/622262507873764
- Espondilite Anquilosante & D3 Vitamina: https://www.facebook.com/groups/945025008881088
- Vitamina D: https://www.facebook.com/vitaminadbrasil
- Nos dizemos ADEUS as doencas autoimunes com Vitamina D: https://www.facebook.com/groups/vitaminad
- Vitamina D e Saude: https://www.facebook.com/groups/644875738973761
- ESCLEROSE MULTIPLA + VITAMINA D = A GRANDE DESCOBERTA=VIDA ! REABILITACAO: https://www.facebook.com/groups/829851020377068
- O tratamento com vitamina D do Dr. Cicero Coimbra - Portugal: https://www.facebook.com/groups/1425762970980967
- A Brigada da Vitamina D e a Esclerose Multipla: https://www.facebook.com/vitaminadem/info
German
- Vitamin D und MS - Coimbraprotokoll: 2568 members Jan 2017
https://www.facebook.com/groups/1584676481835203
Spanish
- Esclerosis Multiple Latinoamerica - Altas Dosis de Vitamina D 1213 members Jan 2017
https://www.facebook.com/groups/emperu/*fref=ts - Bendita Vitamina D: https://www.facebook.com/groups/benditavitaminad
- Esclerosis multiple - COLOMBIA - Vitamina D: https://www.facebook.com/groups/esclerosismultiplecolombiavitminad/*fref=ts
- Altas dosis de vitamina D - Esclerosis Multiple: https://www.facebook.com/Altas-dosis-de-vitamina-D-Esclerosis-M%C3%BAltiple-135790546829648
French
- Vitamine D — Pour une autre therapie: https://www.facebook.com/groups/155432754846598
Italian
- Il protocollo Coimbra in Italia - Alte dosi di vitamina D per autoimmunita: https://www.facebook.com/groups/coimbra.italia
- Per un'altra terapia - Vitamina D per la SM e per le malattie autoimmuni: https://www.facebook.com/groups/protocolloCoimbra
- Vitamina D per SM e altre"malattie autoimmuni": https://www.facebook.com/groups/348361975295212/*ref=browser
- Vitiligine & Vitamina D: https://www.facebook.com/groups/1585908351671283
- Alopecia e protocollo Coimbra: https://www.facebook.com/groups/1676891909213146/*hc_location=ufi
- Vitamina D - Emodieta- protocollo Coimbra...Guarire dalle autoimmunita: https://www.facebook.com/groups/1127525930614216/*fref=nf
- Protocollo Coimbra e Sclerosi Multipla Italia☀️ Alte dosi di vitamina D https://www.facebook.com/groups/835088713314021 455 members added March 2017
Romanian
- Pentru o alta terapie: Vitamina D pentru Scleroza Multipla: https://www.facebook.com/groups/568396633257764
Greek
- Σκλήρυνση κατά πλάκας και βιταμίνη D - Η λύση: https://www.facebook.com/groups/248517068633042
Western Balkan countries, Croatia and Slovenia 7,000 members at end of March 2017
- MS i ostale autoimune bolesti - tretman vitaminom D3: https://www.facebook.com/groups/Dvitamin/*fref=ts
Slovene
- Vitamin D3 - Cudezni hormon !: https://www.facebook.com/groups/213918382289774
Macedonian
- MS Makedonija-LEKUVANJE SO VISOKI DOZI NA D3 VITAMIN: https://www.facebook.com/groups/581798718659139/*hc_location=ufi (240 members Jan 2017)
Lithuanian
- Issetine skleroze (nauja grupe): https://www.facebook.com/groups/483705531797062
Norwegian
- Hoy dose vitamin D3 for MS og andre autoimmune tilstander : https://www.facebook.com/groups/1021897311186644
- CoimbraProtokollen - Informasjon Norge https://www.facebook.com/coimbraprotokollen/ noticed May 2017
Serbian:
- https://www.facebook.com/groups/Dvitamin/*ref=bookmarks (6200 members Jan 2017)
- https://www.facebook.com/groups/msd3tretman/*ref=bookmarks (350 members Jan 2017)
Russian added Feb 2017
Some Facebook pages on just Vitamin D
- Vitamin D Wellness 12,689 members as of Jan 2017
- Vitamin D Deficiency and Treatment 7,075 members as of Jan 2017
- Vitamina D Brazil
VitaminDWiki – Multiple Sclerosis 32 percent less likely among those with more than 32 ng of vitamin D – Dec 2019
- Overview MS and vitamin D
- An opportunity - use Vitamin D to treat Multiple Sclerosis (has been used for 14 years) - Feb 2022
- Multiple Sclerosis treated when use high doses of vitamin D – meta-analysis May 2018
- Multiple Sclerosis: 10 percent fewer relapses for each 10 ng higher level of vitamin D – Meta-analysis April 2020
- Multiple Sclerosis: number needed to treat with vitamin D may be as low as 1.3 – Meta-analysis Oct 2013
- Multiple Sclerosis more likely if poor vitamin D genes - 22nd study – Aug 2017
- Multiple Sclerosis relapses cut in half by 100,000 IU of Vitamin D every 2 weeks– RCT 2019
UV and Sunshine reduces MS risk
- Multiple Sclerosis 2X more likely if low winter UV – June 2018
- Multiple Sclerosis half as likely if get plenty of sunshine (not a news item) – March 2018
Other things also help
- Multiple Sclerosis treated by 50,000 IU Vitamin D bi-weekly plus Omega-3 – RCT July 2018
- Multiple Sclerosis 40 percent less likely if consume tinned fish (Vitamin D and Omega-3) – Sept 2019
- Resveratrol treats Multiple Sclerosis and other autoimmune diseases – many studies
- Not a single case of multiple sclerosis in 15,000,000 people (plant-based diets)
High Dose Vitamin D and cofactors
- Coimbra protocol using high-dose Vitamin D is safe – April 2022
- The use of high dose Vitamin D (Coimbra Protocol) for multiple sclerosis in Germany – 2019
- Comparing High-dose vitamin D therapies MS and other health problems
Number of MS studies which are also in other categories
-
22 studies in Genetics - genes can restrict Vitamin D getting to the blood and to the cells 14 studies in Vitamin D Receptor - gene which restricts D from getting to the cells 7 studies in Vitamin D Binding Protein - gene which restricts D from getting to the cells 21 studies in Ultraviolet light - may be even better than Vitamin D in preventing and treating MS 9 studies in Omega-3 - which helps Vitamin D prevent and treat MS
VitaminDWiki – Comparing High-dose vitamin D therapies
VitaminDWiki – Can get 50,000 IU Vitamin D anywhere on the globe
It appears that less D is needed if one adds any of 14 activators of the Vitamin D Receptor
14 studies in both categories MS and Vitamin D Receptor This list is automatically updated
- Multiple Sclerosis and Vitamin D Receptor Activators
- Multiple Sclerosis: is strongly related to poor Vitamin D receptors – umbrella review Oct 2024
- Poor Vitamin D Receptor increases the risk of Multiple Sclerosis in people of European descent – Feb 2024
- Multiple Sclerosis 2X-3X more likely if poor Vitamin D Receptor – Meta-analysis Feb 2020
- Risk of Multiple Sclerosis varies with the Vitamin D Receptor – meta-analysis Dec 2019
- Multiple Sclerosis and Vitamin D Receptor super enhancers – March 2019
- Vitamin D genes increase MS relapses in children by 2X – May 2019
- Immunological effects of vitamin D and their relations to autoimmunity – March 2019
- Inflammation and immune responses to Vitamin D (perhaps need to measure active vitamin D) – July 2017
- Multiple Sclerosis more likely if poor vitamin D genes - 22nd study – Aug 2017
- Multiple sclerosis (relapsing-remitting) increases activation of Vitamin D Receptor by 6.6 X – March 2017
- Multiple Sclerosis is more likely if poor Vitamin D Receptor (4X Mexico, 3X Iran)– Feb 2017
- Multiple Sclerosis much more likely if poor Vitamin D Receptor – several studies
- Multiple Sclerosis and the Vitamin D Receptor – meta-analysis July 2014
Vitamin D Receptor activation can be increased in 14 ways
Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Butyrate Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 14 known VDR activatorsDoctor got MS and was later cured by high-dose Vitamin D - Aug 20236277 visitors, last modified 10 Aug, 2023, This page is in the following categories (# of items in each category)