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Vitamin D and chronic kidney disease – July 2014

Korean J Intern Med. Jul 2014; 29(4): 416–427.
Published online Jun 27, 2014. doi: 10.3904/kjim.2014.29.4.416
PMCID: PMC4101586
Chang Seong Kim and Soo Wan Kim

Chronic kidney disease (CKD) has been recognized as a significant global health problem because of the increased risk of total and cardiovascular morbidity and mortality. Vitamin D deficiency or insufficiency is common in patients with CKD, and serum levels of vitamin D appear to have an inverse correlation with kidney function. Growing evidence has indicated that vitamin D deficiency may contribute to deteriorating renal function, as well as increased morbidity and mortality in patients with CKD. Recent studies have suggested that treatment with active vitamin D or its analogues can ameliorate renal injury by reducing fibrosis, apoptosis, and inflammation in animal models; this treatment also decreases proteinuria and mortality in patients with CKD. These renoprotective effects of vitamin D treatment are far beyond its classical role in the maintenance of bone and mineral metabolism, in addition to its pleiotropic effects on extra-mineral metabolism. In this review, we discuss the altered metabolism of vitamin D in kidney disease, and the potential renoprotective mechanisms of vitamin D in experimental and clinical studies. In addition, issues regarding the effects of vitamin D treatment on clinical outcomes are discussed.

PDF is attached at the bottom of this page

Note: GFR = Glomerular Filtration Rate

See also VitaminDWiki

Overview Kidney and vitamin D there are many ways of increasing vitamin D even when kidney is not functioning well
Time-release form of active vitamin D granted a patent for chronic kidney disease – July 2014
4X more Chronic Kidney disease patients are now using vitamin D – March 2014
Kidney Inflammation: both prevented and reduced by Vitamin D – review Jan 2014

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The beneficial impact of vitamin D treatment in CKD patients: what's next? Dec 2014
Concludes that there is little evidence that vitamin D helps CKD. Summary table does not indicate how much was used, nor type

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Vitamin D and chronic kidney disease – July 2014

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4751	CKD Dec 2014.jpg		admin 18 Dec, 2014	248.66 Kb	1703
4750	CKD 2014.pdf		admin 18 Dec, 2014	70.81 Kb	1128
4191	CKD trials.jpg		admin 26 Jul, 2014	286.76 Kb	2822
4190	CKD F1.jpg		admin 26 Jul, 2014	65.65 Kb	8053
4189	CKD July 2014.pdf		admin 26 Jul, 2014	471.20 Kb	843

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