Mechanistic Effects of Vitamin D Supplementation on Metabolic Syndrome Components in Patients with or without Vitamin D Deficiency
Review J Obes Metab Syndr. 2020 Aug 4. doi: 10.7570/jomes20003
Samira Faraji 1 2, Mohammad Alizadeh 2 3
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MetS “ … can increase the risk of other diseases, such as a
2-fold increase in risk for cardiovascular disease
2- to 4-fold for stroke
5-fold or more for type 2 diabetes, and
3- to 4-fold for myocardial infarction.”
Metabolic Syndrome has the following
See also
- Overview Metabolic Syndrome and vitamin D
- Overview Diabetes and vitamin D
- Overview Obesity and Vitamin D
- Diabetes, Metabolic Syndrome and Magnesium - many studies
- Arteries and Atherosclerosis and Vitamin D - many studies
- Metabolic Syndrome risk decreases by 20 percent with each 10 ng increase in Vitamin D - April 2021
- Metabolic Syndrome and Vitamin D - review of 33 studies - March 2021
- Metabolic Syndrome far less likely if high Vitamin D – 3 meta-analyses 2021
- Metabolic Syndrome 11X more likely if have a poor Vitamin D Receptor – 2018
- Vitamin D is linked to metabolic syndrome and obesity – Aug 2019
- Risk of Metabolic syndrome for senior women reduced 42 percent by 1,000 IU of vitamin D – RCT June 2019
- Metabolic Syndrome risk reduced 3.7 X by nuts (Magnesium, Omega-3) – Dec 2018
- Metabolically Healthy – only 1 in 50 seniors in the US – Nov 2018
- Metabolic Syndrome indicators inversely proportional to vitamin D below 46 ng – Nov 2018
- Metabolic Syndromes fought by Vitamin D in 6 ways – Oct 2023
Items in both categories Metabolic Syndrome and Diabetes are listed here:
- Metabolic Syndromes fought by Vitamin D in 6 ways – Oct 2023
- UV reduces cardiovascular and metabolic problems– Vitamin D plus Nitric oxide – Sept 2023
- T1 Diabetes increased by 27% by second year of COVID – meta-analysis June 2023
- Diabetes 3X more likely if had COVID ICU (VDR was deactivated) - April 2023
- Diabetes, Metabolic Syndrome and Magnesium - many studies
- Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes - Jan 2021
- The Role of Magnesium in the Pathogenesis of Metabolic Disorders – April 2022
- How Vitamin D prevents Insulin Resistance – Sept 2020
- Waist size reduced 3 cm by Vitamin D in those with Metabolic Syndrome – Jan 2017
- Cardiometabolic risk reduced by Omega-3 - dissertation Sept 2017
- Upsurge in Metabolic diseases may be due to low vitamin D – May 2016
- Psoriasis is associated with kidney disease, heart problems, diabetes, etc – Nov 2015
- More vitamin D makes for better health – dissertation based on Rotterdam studies – Oct 2015
- Diabetic hypertension reduced with Vitamin D and Calcium – RCT March 2015
- Daily Magnesium improved all aspects of metabolic profile – RCT July 2014
- Hypothesis- Metabolic disease is due to Tissue Renin-Angiotensin Systems – Feb 2014
- Cardiometabolic markers indicate that 11-14 ng is enough vitamin D – Nov 2013
- Metabolic Syndrome 10% less likely for every 4 ng increase in Vitamin D – Jan 2013
- Metabolic Syndrome in children is associated with low vitamin D – review Jan 2013
- Overview Metabolic Syndrome and vitamin D
Items in categories Metabolic Syndrome AND Obesity
- Metabolic Syndromes fought by Vitamin D in 6 ways – Oct 2023
- UV reduces cardiovascular and metabolic problems– Vitamin D plus Nitric oxide – Sept 2023
- Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes - Jan 2021
- The Role of Magnesium in the Pathogenesis of Metabolic Disorders – April 2022
- Vitamin D is linked to metabolic syndrome and obesity – Aug 2019
- Metabolic Syndrome associated with low vitamin D in abdominal obese women – Jan 2019
- Obesity and Vitamin D – Review July 2018
- How Omega-3 fights metabolic syndrome and weight – Feb 2018
- BMI reduced by Vitamin D (not much reduction – only got VitD to 26 ng) – RCT Feb 2018
- Waist size reduced 3 cm by Vitamin D in those with Metabolic Syndrome – Jan 2017
- Metabolic Syndrome with and without obesity has low vitamin D - Oct 2016
- Obese youths 2X less likely to develop Metabolic Syndrome if take Omega-3 – RCT April 2016
- Hypothesis: Energy metabolism is associated with Vitamin D – April 2015
- Diabetic hypertension reduced with Vitamin D and Calcium – RCT March 2015
- UV (perhaps Nitric Oxide) better than vitamin D at preventing obesity in rats on a high-fat diet – Nov 2014
- Hypothesis- Metabolic disease is due to Tissue Renin-Angiotensin Systems – Feb 2014
- UV better than vitamin D in reducing metabolic syndrome in mice – Thesis Aug 2013
- Metabolic Syndrome 10% less likely for every 4 ng increase in Vitamin D – Jan 2013
- 5700 IU vitamin D improved various growth factors in overweight people – Oct 2012
- 3X more abdominal obesity among Korean children having low vitamin D – July 2012
- Overview Metabolic Syndrome and vitamin D
Download the PDF from VitaminDWiki
The prevalences of metabolic syndrome (MetS) and vitamin D deficiency are increasing dramatically worldwide. MetS in itself is not a disease but is a major challenge because it can increase the risk of most non-communicable diseases. The beneficial effect of vitamin D on MetS components remains controversial, so the present review focused on the clinical effects of vitamin D supplementation on MetS components.
Vitamin D can inhibit the protein expression of nuclear factor beta; improve arterial stiffness; decrease renin-angiotensin-aldosterone system activity, parathyroid hormone levels, inflammatory cytokines, 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA)-reductase, and lanosterol 14 β-demethylase enzyme activity; increase the activity of lipoprotein lipase; alter gene expression in C2C12 cells; and improve phospholipid metabolism and mitochondrial oxidation. We tried to elucidate and analyze almost all evidence from randomized controlled trial studies of the efficacy of vitamin D supplementation in patients with MetS. The findings of the present study reported beneficial effects of vitamin D supplementation on mentioned factors. Vitamin D supplementation is recommended in people with vitamin D deficiency even if it has no considerable effect on most MetS factors. However, existing data from interventional studies are insufficient to reach a definitive conclusion about the effect of vitamin D supplementation on MetS components in patients without vitamin D deficiency. Thus, new clinical studies are needed to test the hypothesis that vitamin D supplementation could alleviate MetS components in patients with sufficient intake of vitamin D.
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| 14121 | Metabolic Syndrome.pdf | admin 05 Aug, 2020 | 984.59 Kb | 398 |