Research Progress on the Role of Vitamin D in Autism Spectrum Disorder
Front Behav Neurosci. 2022 May 10;16:859151. doi: 10.3389/fnbeh.2022.859151
Jing Wang 1, Haoyu Huang 1, Chunming Liu 1, Yangping Zhang 1, Wenjuan Wang 1, Zhuo Zou 1, Lei Yang 1, Xuemei He 1, Jinting Wu 1, Jing Ma 2, Yun Liu 1
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that can lead to severe social behavioral difficulties, which mainly manifests as social communication and interaction disorders; narrow interests; and repetitive, stereotyped behaviors. In recent years, the prevalence of ASD has increased annually, and it has evolved from a rare disease to one with a high incidence among childhood developmental disorders. The pathogenesis of ASD is considered to be the interaction of genetic and environmental factors. There is increasing evidence that vitamin D deficiency in pregnancy and early childhood can lead to the occurrence of ASD. Studies have demonstrated that vitamin D intervention can significantly improve the symptoms of ASD, but the underlying mechanism is still unclear. Therefore, exploring the neuroprotective mechanism of vitamin D against ASD is a huge challenge currently being worked on by current basic and clinical researchers, a task which is of great significance for the clinical promotion and optimization of vitamin D in the treatment of ASD. To further clarify the relationship between vitamin D and ASD, this review summarizes the correlation between vitamin D level and ASD, the effects of vitamin D supplementation on ASD, the possible mechanism of vitamin D involved in ASD, and insights from ASD animal models.
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Autism category contains
Autism category has - see also Overview Autism and vitamin D, Autoimmune , Cognitive, ADHD
Interesting Autistic studies
Autism associated with low Vitamin D
- Most Autism Risk factors are associated with low vitamin D - March 2014
- Rickets – 26 percent had autism: no rickets, no autism (both associated with low vitamin D) – June 2015
- Autistics have half of the response to Vitamin D – RCT Oct 2018
- Vitamin D fights autism - trying to figure out how and why – May 2022
Autism TREATED by Vitamin D
- Autism in children reduced by Vitamin D (used 300 IU per kg per day) – RCT Oct 2016
- Autism treated by Vitamin D (monthly injection of 150,000 IU) – June 2017
- Autism decreased in 8 out of 10 children supplemented with vitamin D – April 2015
Autism PREVENTED by vitamins before and during pregnancy
- Autism risk is reduced by Vitamin D – early pregnancy or chlldhood – Umbrella review – July 2024
- Vitamin D and autism - treat: 300 IU per kg per day, prevent: during pregnancy 5,000 IU – Feb 2017
- Autism reduced 24% for each 4 ng more Vitamin D while pregnant ( ADHD 12%) – Feb 2024
- Autism rate cut in half when multivitamins (including vitamin D) used during pregnancy – Oct 2017
- Autism risk reduced 2X by prenatal vitamins (Vitamin D or Folic) – Feb 2019
- Autism 3X more likely after closely spaced pregnancy vs 3 year apart– Jan 2011
- Low Vitamin D decreases fertility and increases subsequent autism, ADHD, etc – Feb 2018
- Women who had supplemented with any vitamins were 6 X less likely to have autistic offspring – Jan 2018
- Autism rate in siblings reduced 4X by vitamin D: 5,000 IU during pregnancy, 1,000 IU to infants – Feb 2016
Autism and Vitamin D Receptor (not enough Vit D gets to the cells)
This list is automatically updated
- More than 30% of Autistics also have ADHD - Nov 2024
- Autism treated by an activator of the Vitamin D Receptor: supforaphane - March 2024
- Autism may be synergistically treated by Vitamin D and probiotics – July 2022
- Autism 2X to 3X more likely if poor Vitamin D Receptor – June 2020
- A good Vitamin D Receptor (or perhaps more vitamin D) protects against lead during pregnancy
- Autism much more likely if poor Vitamin D Receptor – many studies
Autism - other risk factors
- Autistic symptoms reduced by Vitamin D and or Omega-3 – RCT March 2019
- Autism risk increased if infant had antibiotics (2X), acetaminophen (3X), or no vitamin D drops (1.5X) – June 2018
- 20 X more Parkinson's and 100X more Autism with GMO soy in China
- Note >100X increase in Autism while having GMO soy in the US
- Fewer neurons in males born from COVID-19 vaccinated mothers (rats) - Jan 2024
- Vaccinations resulted in increased office visits for children 16 months later - Nov 2020
- Does a vaccine increase the risk of Autism – March 2019
- Autism 2.75 X more likely in Hib vaccines containing Mercury – May 2018
- Vaccinated children had more chronic diseases - Sept 2018
- Autism and ADHD type disorders were 14X more likely in survey of extreme preterm vaccinated infants - April 2017
Dr. Cannell on Autism and Vitamin D in VitaminDWiki
- Autism treated by Vitamin D (80 – 120 ng) – Cannell update May 2018
- Autism Causes, Prevention and Treatment: Vitamin D Deficiency etc. – Book April 2015 Cannell
- Autism cured in a child with Vitamin D, Dr. Cannell comments and cofactor recommendations – March 2015
- Autism and Vitamin D - Dr. Cannell in Life Extension Mag - Jan 2014
- Autism treated by Vitamin D: Dr. Cannell - video June 2013
- includes his list of 27 reasons to associate Vitamin D with Autism in 2013
- Many autistic children are getting some Vitamin D, Omega-3, probiotics, etc. – Aug 2019
- Autistic symptoms reduced by Vitamin D and or Omega-3 – RCT March 2019
- Omega-3 probably can decrease Autism and ADHD – March 2019
- Autism treated in one person by Omega-3 plus Vitamin D – Dec 2018
- Autism problems reduced by Vitamin D, Omega-3 – RCT Oct 2018
- ADHD, Autism, Early Psychosis and Omega-3 – review Dec 2017
- Autism risks include chemicals, deficiency of vitamin D, Omega-3 – mini-review April 2016
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