Vitamin D deficiency causes rickets in an urban informal settlement in Kenya and is associated with malnutrition
Matern Child Nutr. 2018 Jan; 14(1): online 2017 May 3. doi: 10.1111/mcn.12452
PMCID: PMC5763407, PMID: 28470840
Kelsey D. J. Jones, 1 , 2 C. Ulrich Hachmeister, † Maureen Khasira, 1 Lorna Cox, 4 Inez Schoenmakers, 4 , 5 Caroline Munyi, 3 H. Samira Nassir, 3 Barbara Hünten‐Kirsch, 3 Ann Prentice, 4 , 6 and James A. Berkley 1 , 7
Subset of table
| % | |
| Wrist widening | 100 % |
| Rachitic rosary | 90 % |
| Swollen knees | 19 % |
| Bowed legs | 14 % |
| Bone pain on walking | 5 % |
| Minor feature – Open Fontanelle | 90 % |
| Minor feature – Double malleoli | 52 % |
| Minor feature – Harrison's groove | 48 % |
| Minor feature – Developmental delay | 52 % |
| Comorbidity – URTI | 62 % |
Wrist widening images from the web
Rachitic rosary images from the web
See also VitaminDWiki
- Rickets needs Vitamin D and Calcium - Global Consensus Jan 2016
- Rickets very prevalent in Mongolia – 1998
- Dark skin, no supplementation, no fish, far from equator
- Rickets in 30 percent of infants in India who had low vitamin D – March 2011
- Black Sudanese children 350X more likely to have rickets than other Australians – April 2012
- (Rare Nutritional Rickets increased 10X in 20 years – Feb 2013))
- Shaken Baby Syndrome - probably caused by Ehlers-Danlos Syndrome
- Sunshine can prevent rickets – Poland 1822
- Biochemical rickets non-existent if breastfeeding mother got 600,000 IU of vitamin D (3 dollars) – RCT Dec 2017
Overview of Rickets and vitamin D contains the following summary
Rate of rickets is usually < 0.1% of births, unless dark skin, breastfed, preemie, twin, Mongolian, or Russian
Rate of rickets has greatly increased with the drop in vitamin D levels during the past 40 years
400 IU can prevent/treat most rickets Turkey gave vitamin D to EVERY child and eliminated Rickets
Can have rickets without a low serum level of vitamin D (~20% of the time)
Giving enough Vitamin D to the mother (before and after birth) PREVENTS most forms of Rickets
Rate of rickets in some countries varies from 10% to 70% (typically poor health overall)
Rickets has been more than doubling in many countries
Rickets is strongly associated with severe breathing problems (weak ribs)
Bowed legs is not the primary indication of rickets (3 other indications of rickets are seen more often)
Rickets is typically due to low cellular Vitamin D - April 2024
Some Rickets is due to poor genes - Vitamin D needed lifelong – June 2020
Vitamin D and Rickets consensus took 80 years
Download the PDF from VitaminDWiki
The commonest cause of rickets worldwide is vitamin D deficiency, but studies from sub‐Saharan Africa describe an endemic vitamin D‐independent form that responds to dietary calcium enrichment. The extent to which calcium‐deficiency rickets is the dominant form across sub‐Saharan Africa and in other low‐latitude areas is unknown. We aimed to characterise the clinical and biochemical features of young children with rickets in a densely populated urban informal settlement in Kenya. Because malnutrition may mask the clinical features of rickets, we also looked for biochemical indices of risk in children with varying degrees of acute malnutrition. Twenty one children with rickets, aged 3 to 24 months, were identified on the basis of clinical and radiologic features, along with 22 community controls, and 41 children with either severe or moderate acute malnutrition. Most children with rickets had wrist widening (100%) and rachitic rosary (90%), as opposed to lower limb features (19%). Developmental delay (52%), acute malnutrition (71%), and stunting (62%) were common. Compared to controls, there were no differences in calcium intake, but most (71%) had serum 25‐hydroxyvitamin D levels below 30 nmol/L. These results suggest that rickets in young children in urban Kenya is usually driven by vitamin D deficiency, and vitamin D supplementation is likely to be required for full recovery. Wasting was associated with lower calcium (p = .001), phosphate (p < .001), 25‐hydroxyvitamin D (p = .049), and 1,25‐dihydroxyvitamin D (p = 0.022) levels, the clinical significance of which remain unclear.
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| 10288 | RR2.jpg | admin 04 Aug, 2018 | 6.97 Kb | 7014 | |
| 10287 | RR1.jpg | admin 04 Aug, 2018 | 8.01 Kb | 1519 | |
| 10286 | Rickets wrist 3.jpg | admin 04 Aug, 2018 | 4.29 Kb | 1268 | |
| 10285 | Rickets wrist 2.jpg | admin 04 Aug, 2018 | 5.32 Kb | 1244 | |
| 10284 | Rickets wrist 1.jpg | admin 04 Aug, 2018 | 6.40 Kb | 1835 | |
| 10283 | Kenya rickets.pdf | admin 04 Aug, 2018 | 586.37 Kb | 824 |