Maternal 25(OH)D attenuates the relationship between ambient air pollution during pregnancy and fetal hyperinsulinism
Chemosphere . 2023 Mar 16;138427. doi: 10.1016/j.chemosphere.2023.13842 PDF is behind a paywall
Peng Wang 1, Wan-Jun Yin 1, Ying Zhang 2, Xiao-Min Jiang 3, Xiao-Guang Yin 4, Yu-Bo Ma 5, Fang-Biao Tao 1, Rui-Xue Tao 6, Peng Zhu 7
Inflammatory responses have been demonstrated to link air pollution with insulin resistance and type 2 diabetes in adults. However, few studies have focused on the relationship between prenatal air pollution and fetal ß-cell function and the mediating effect of systematic inflammation remains elusive. Whether the anti-inflammatory effect of vitamin D could attenuate the ß-cell dysfunction in early life warrants further investigations. We aimed to determine whether maternal blood 25(OH)D attenuates the associations of ambient air pollution during pregnancy with fetal hyperinsulinism mediated by maternal inflammatory response. A total of 8250 mother-newborn pairs were included between 2015 and 2021 in the Maternal & Infants Health in Hefei study. Weekly mean air pollution exposure to fine particles (PM2.5 and PM10), SO2, and CO was estimated across pregnancy.
Maternal serum samples in the third trimester were used to measure the high-sensitivity c-reactive protein (hs-CRP) and 25(OH)D. Cord blood samples at delivery were collected for the measurement of C-peptide. Fetal hyperinsulinism was based on cord C-peptide >90th centile. An increased fetal hyperinsulinism risk was associated with per 10 µg/m3 increase in PM2.5 [odds ratios (OR): 1.45 (95% confidence interval (CI):1.32, 1.59)], per 10 µg/m3 increase in PM10 [OR = 1.49 (95% CI:1.37, 1.63)], per 5 µg/m3 increase in SO2 [OR = 1.91 (95% CI: 1.70, 2.15)], and per 0.1 mg/m3 increase in CO [OR = 1.48 (95% CI:1.37, 1.61)] across pregnancy.
Mediation analysis showed a 16.3% contribution of maternal hsCRP to the relationship between air pollution throughout pregnancy and fetal hyperinsulinism.
Air pollution-associated higher levels of hsCRP and risk of fetal hyperinsulinism could be attenuated by higher maternal 25(OH)D levels. Prenatal ambient air pollution exposures were associated with an increased fetal hyperinsulinism risk mediated by maternal serum hsCRP. Higher antenatal 25(OH)D levels could attenuate air pollution-induced inflammatory responses and hyperinsulinism risk.
VitaminDWiki Air Pollution reduces Vitamin D production - many studies contains
Fact: Pollution reduces the amount of time that people are outdoors
Fact: Pollution is often associated with hot temperatures - another reason to not go outdoors
Fact: Less time outdoors results in lower Vitamin D levels
Fact: Pollution attenuates the amount of UVB getting to the skin (but by only a few percent)
Fact:The body's ability to fight Irritation/Inflammation is aided by vitamin D
Fact: All of the types of PM2.5 deaths are also associated with low vitamin D
Most air pollutions reduce Vitamin D (PM2.5 is worst) – June 2021
Conclusion: Vitamin D supplementation helps the body fight the effects of pollution.
- There were 60+ references in Air Pollution reduces Vitamin D page as of June 2023
- Inhaled vitamin D might turn out to be especially good form as it goes directly to the lungs.