DHCR7: A vital enzyme switch between cholesterol and vitamin d production
Progress in Lipid Research, online 30 Sept 2016, http://dx.doi.org/10.1016/j.plipres.2016.09.003
Anika V. Prabhua, Winnie Luua, Dianfan Lib, Laura J. Sharpea, Andrew J. Browna, ,
- GC, CYP2R1 and DHCR7 genes associated with low vitamin D levels in China – 2012, 2013
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- Overview Cholesterol and vitamin D
- More cholesterol is associated with more vitamin D – June 2013
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63 items - CYP24A1 in title of 39+ items
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62 items - Topical Vitamin D
- Nanoemulsion Vitamin D may be a substantially better form
- 1289 genes changed with higher doses of Vitamin D - RCT Dec 2019
- CYP3A4 (7 as of Dec 2022)
- Getting Vitamin D into your body
Vitamin D blood test misses a lot
- Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
- Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
- A Vitamin D test in cells rather than blood was feasible (2017 personal communication) Commercially available 2019
- However, test results would vary in each tissue due to multiple genes
- Good clues that Vitamin D is being restricted from getting to the cells
1) A vitamin D-related health problem runs in the family
especially if it is one of 51+ diseases related to Vitamin D Receptor
2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase)
3) DNA and VDR tests - 100 to 200 dollars $100 to $250
4) PTH bottoms out ( shows that parathyroid cells are getting Vitamin d)
Genes are good, have enough Magnesium, etc.
5) Back Pain
probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc- The founder of VitaminDWiki took action with clues #3&5
The conversion of 7-dehydrocholesterol to cholesterol, the final step of cholesterol synthesis in the Kandutsch-Russell pathway, is catalyzed by the enzyme 7-dehydrocholesterol reductase (DHCR7). Homozygous or compound heterozygous mutations in DHCR7 lead to the developmental disease Smith-Lemli-Opitz syndrome, which can also result in fetal mortality, highlighting the importance of this enzyme in human development and survival. Besides serving as a substrate for DHCR7, 7-dehydrocholesterol is also a precursor of vitamin D via the action of ultraviolet light on the skin.
Thus, DHCR7 exerts complex biological effects, involved in both cholesterol and vitamin D production. Indeed, we argue that DHCR7 can act as a switch between cholesterol and vitamin D synthesis. This review summarizes current knowledge about the critical enzyme DHCR7, highlighting recent findings regarding its structure, transcriptional and post-transcriptional regulation, and its links to vitamin D synthesis. Greater understanding about DHCR7 function, regulation and its place within cellular metabolism will provide important insights into its biological roles.Download the PDF from sci-hub via VitaminDWiki
Outline
Title change made March 2021 caused the visitor count to reset.
1. Introduction
1.1. The history of DHCR7
2. Implications in Human Health And Disease
2.1. Smith-Lemli-Opitz syndrome
2.2. Health effects of 7-dehydrocholesterol and its derivatives
2.3. Role of sterols in embryogenesis
2.4. Vitamin D3 status
3. Characterization of The DHCR7 protein
3.1. DHCR7 topology and structure
3.2. Important domains of DHCR7
3.3. Evolution of DHCR7
4. Regulation of DHCR7
4.1. Transcriptional regulation of DHCR7
4.2. Post-transcriptional regulation of DHCR7
5. Concluding Remarks
There have actually been9997 visitors to this page since it was originally made DHCR7 enzyme (gene) synthesizes cholesterol or vitamin D (when UVB is available) – Sept 2016Printer Friendly Follow this page for updates7311 visitors, last modified 13 Mar, 2021, This page is in the following categories (# of items in each category) - Vitamin D Binding Protein = GC has
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