Chronic Latent Magnesium Deficiency in Obesity Decreases Positive Effects of Vitamin D on Cardiometabolic Risk Indicators.
Curr Vasc Pharmacol. 2017 Aug 21. doi: 10.2174/1570161115666170821154841. [Epub ahead of print]
Stokic E1, Romani A2, Ilincic B1, Kupusinac A3, Stosic Z1, Isenovic ER4.
1 Clinical Center of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad. Serbia.
2 Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland. United States.
3 Faculty of Technical Sciences, University of Novi Sad, Novi Sad. Serbia.
4 Laboratory for Molecular Genetics and Radiobiology, Institute Vinca, University of Belgrade, Belgrade. Serbia.
- Overview Metabolic Syndrome and vitamin D
- Overview Diabetes and vitamin D
- Can Vitamin D treat Diabetes - many articles in addition to prevent
- HbA1c levels (Diabetes) reduced by monthly 50,000 IU of vitamin D – Dec 2017
- Diabetes helped by daily 4,000 IU of Vitamin D – meta-analysis Sept 2017
Items in both categories Magnesium and Diabetes are listed here:
- Vitamin D Roles - more than just help the immune system
- Retinopathy in males 6.9 X more likely if low vitamin D and low Magnesium - June 2024
- Magnesium Depletion Score predicts increased risk of various health problems
- High fluoride in water: 5X more likely to be Vitamin D deficient – Jan 2023
- Diabetes, Metabolic Syndrome and Magnesium - many studies
- More Magnesium needed to decrease diabetes, cardio, HT (body weight has increased) - March 2021
- Treating pre-diabetes with Magnesium Chloride should be cost effective – June 2022
- Reduced Magnesium is associated with reduced health (Diabetes in this case) - April 2022
- Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes - Jan 2021
- The Role of Magnesium in the Pathogenesis of Metabolic Disorders – April 2022
- Magnesium fights diabetes (yet again)– meta-analysis Nov 2021
- Excessive insulin decreases vitamin D in 4 ways – problems for diabetic COVID-19 – Dec 2020
- Low Magnesium associated with diabetes, etc. – meta-analysis 2016
- Low Level Laser Therapy greatly increased Vitamin D and Magnesium (for diabetics with nephropathy) – March 2019
- Young Diabetics had 3.8 X higher risk of Parkinson’s (perhaps low Mg or low Vitamin D)– June 2018
- Cardiometaboic problems decreased with increased Vitamin D, unless low Magnesium – Aug 2017
- Diabetes 29 % less likely if consume lots of Magnesium and cereal fiber (surveys of 200,000 people) – Oct 2017
- Magnesium is associated with prevention and treatment of Diabetes – Meta-analysis Aug 2016
- Type 2 diabetes associated with low Magnesium
- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
- More vitamin D makes for better health – dissertation based on Rotterdam studies – Oct 2015
- Prediabetes reduced in half by those getting Magnesium Chloride – RCT April 2015
- Type II Diabetes might be prevented and treated with Magnesium – Review Feb 2015
- Diabetes decreased with 300 mg of Mg (Mg Sulfate) – RCT July 2014
- Daily Magnesium improved all aspects of metabolic profile – RCT July 2014
- Diabetes and low Magnesium - Mercola 2014 - 2019
- Diabetics have problems with low Magnesium, especially if taking statins – Aug 2013
- Low Magnesium and type II diabetes – June 2012
- Hypothesis: Decreasing Magnesium and increasing CaMg ratio are increasing health problems – 2012 - 2013
- Reduced chance of diabetes 46 percent with Magnesium - Oct 2010
Items in both categories Magnesium and Cardiovascular are listed here:
- More Magnesium needed to decrease diabetes, cardio, HT (body weight has increased) - March 2021
- Nitric oxide increased by UVA, Vitamin D, Magnesium, etc,
- Atrial Fibrillation decreased by Vitamin D or Magnesium - many studies
- Signs of low Magnesium (heart problems in this case) – Jan 2018
- Ablation does not reduce atrial fibrillation (CABANA study) but Magnesium does – June 2018
- Cardiometaboic problems decreased with increased Vitamin D, unless low Magnesium – Aug 2017
- Heart problems in obese increase if deficient in BOTH Vitamin D and Magnesium – Aug 2017
- Health problems prevented by eating nuts (perhaps due to Magnesium and or Omega-3) – meta-analysis Dec 2016
- Cardiovascular calcification prevented by Omega-3, Magnesium, Vitamin K, and Vitamin D – April 2015
- More vitamin D makes for better health – dissertation based on Rotterdam studies – Oct 2015
- Atrial Fibrillation - remineralize your heart - Aug 2015
- Magnesium Suppresses Formation of Clogged Arteries - May 2014
- Off Topic: EDTA similar reduction in heart attack as Vitamin C, aspirin and Mg – RCT March 2013
- Death from Coronary Heart Disease related to low Magnesium intake – March 2013
- Magnesium prevents cardiovascular events – Meta-analysis March 2013
- Hypothesis: Decreasing Magnesium and increasing CaMg ratio are increasing health problems – 2012 - 2013
- Heart problems such as Afib related to little Magnesium, Omega-3, Vitamin D getting to tissues
Items in both categories Magnesium and Hypertension are listed here:
- Vitamin D Roles - more than just help the immune system
- Magnesium raised Vitamin D, lowered blood pressure and Ca to Mg ratio – RCT Sept 2024
- Magnesium Depletion Score predicts increased risk of various health problems
- Magnesium reduces hypertension - FDA allows claim - Jan 2022
- Hypertension reduced by Magnesium plus 3,000 IU of vitamin D for 12 weeks – RCT July 2022
- More Magnesium needed to decrease diabetes, cardio, HT (body weight has increased) - March 2021
- Hypertension treatment needs at least 600 mg of Magnesium (49 trials) – Jan 2021
- The Role of Magnesium in the Pathogenesis of Metabolic Disorders – April 2022
- Reduce blood pressure by 9 mm with triple hypertensive drug or 19 mm with Magnesium – April 2018
- Hypertension nonconventional therapies: Magnesium, melatonin, Vitamin C, etc. – Jan 2018
- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
- Prehypertension risk is increased by 78% if low Magnesium – Aug 2015
- Preeclampsia inversely proportional to serum Magnesium – Oct 2014
- Hypertension 1.5X more likely if low level of Magnesium - Oct 2014
Items in both categories Magnesium and Metabolic Syndrome are listed here:
- Diabetes, Metabolic Syndrome and Magnesium - many studies
- Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes - Jan 2021
- The Role of Magnesium in the Pathogenesis of Metabolic Disorders – April 2022
- Metabolic Syndrome risk reduced 3.7 X by nuts (Magnesium, Omega-3) – Dec 2018
- Magnesium in Healthcare (Rickets, Stones, Pregnancy, Depression, etc.) with level of evidence – Sept 2017
- Metabolic Syndrome treatment by vitamin D probably helped by Vitamin A, Zinc, and Magnesium – July 2016
- More vitamin D makes for better health – dissertation based on Rotterdam studies – Oct 2015
- Metabolic Syndrome risk decreases 12 percent with 150 mg of Magnesium – meta-analysis Dec 2014
- Daily Magnesium improved all aspects of metabolic profile – RCT July 2014
BACKGROUND:
Obesity and micronutrient deficiencies contribute to the risk of cardiometabolic diseases such are type 2 diabetes mellitus and cardiovascular disease (CVD).
OBJECTIVE:
We examined the frequency of concomitant deficit of magnesium (Mg) and vitamin D in obese patients and evaluated the connection of these combined deficiencies with indicators of cardiometabolic risk in non-diabetic subjects.
METHOD:
Non-diabetic middle aged adults (n = 80; mean age 36 ± 4 years, 52% women) were recruited based on weight/adiposity parameters [i.e. body mass index (BMI) and body fat percentage (FAT%)]. Cardiometabolic risk indicators [insulin resistance (Homeostatic Model Assessment for insulin resistance (HOMA-IR)) and CVD risk (Framingham risk score for predicting 10-year CVD)], Mg status [i.e. total serum Mg concentration (TMg), chronic latent Mg deficiency (CLMD) - 0.75-0.85 mmol/L], vitamin D status [i.e. serum concentration of 25-hydroxyvitamin D (25(OH)D), vitamin D deficiency <50 nmol/l] were assessed.
RESULTS:
Among obese subjects 36% presented a combination of vitamin D deficiency and CLMD. In all studied patients, 25(OH)D and TMg levels both, individually and combined, showed a negative linear correlation with HOMA-IR and CVD risk. In subjects with CLMD (TMg ˂0.85 mmol/L), a negative linear coefficient was found between 25(OH)D and, HOMA-IR and CVD risk, compared with subjects with normal TMg status (TMg ≥0.85 mmol/L).
CONCLUSION:
CLMD and vitamin D deficiency may commonly be present in obese non-diabetic subjects. Individually and combined, both deficiencies predispose non-diabetic patients to increased risk of cardiometabolic diseases. Maintaining normal Mg status may improve the beneficial effects of vitamin D on cardiometabolic risk indicators.
PMID: 28828979 DOI: 10.2174/1570161115666170821154841