Increased risk of various cancers if poor vitamin D genes (Binding Protein and CYP27B1) - Sept 2019

63 items in CYP27B1 category

Genetics category listing contains the following

344 articles in the Genetics category

see also

• Vitamin D Receptor has 533 items
• Vitamin D Binding Protein = GC has 178 items
• CYP27B1 has 63 items
• CYP24A1 in title of 39+ items
• CYP2R1 25+ items
• Calcidiol has 49 items
• Calcitriol has 63 items
• Topical Vitamin D
• Nanoemulsion Vitamin D may be a substantially better form
• 1289 genes changed with higher doses of Vitamin D - RCT Dec 2019
• CYP3A4 (7 as of Dec 2022)
• Getting Vitamin D into your blood and cells
• 

Vitamin D blood test misses a lot

• Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
• Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
• A Vitamin D test in cells rather than blood was feasible (2017 personal communication)   Commercially available 2019
  • However, test results would vary in each tissue due to multiple genes
• Good clues that Vitamin D is being restricted from getting to the cells
  1) A vitamin D-related health problem runs in the family
      especially if it is one of 51+ diseases related to Vitamin D Receptor
  2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase)
  3) DNA and VDR tests - 100 to 200 dollars $100 to $250
  4) PTH bottoms out ( shows that parathyroid cells are getting Vitamin d)
     Genes are good, have enough Magnesium, etc.
  5) Back Pain
     probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
  • The founder of VitaminDWiki took action with clues #3&5

Vitamin D Binding Protein category listing has 178 items and the following introduction__

Vitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,

• GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
• The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
• The actual D getting to the cells is a function of measured D and all 4 genes
• There is >2X increase in 8+ health problems if have poor VDBP (GC)
• It appears that VDBP only blocks oral vitamin D,
  • but NOT Vitamin D from sun, UV, topical or inhaled (tissue activated)
  • A clue: - Vitamin D from UV is 2X better for MS than oral Vitamin D

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Items in both categories Vitamin D Binding Protein and Breast Cancer are listed here:

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Items in both categories Vitamin D Binding Protein and Other Cancer are listed here:

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Note: This study did not investigate many other genes which also restrict D from getting to the cells

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Additional information on Genes in VitaminDWiki

Gene	# of pages	Location
CYP27A1	449 (Sept 2019)	Liver
*CYP2R1	826 (Sept 2019)	Liver & Tissue
CYP27B1	1430   (Sept 2019)	Kidney & Tissue
CYP24A1	28 in title - May 2022]	excrete excess

• Vitamins regulate some human genes – Feb 2020
• The genetics of vitamin D – Oct 2018
• Does survival of the less fit mean less health (poor genes may be inherited)
  • genes getting worse over generations
• 1289 genes changed with higher doses of Vitamin D - RCT Dec 2019
• Vitamin D deficiency is associated with 35 genes, only 7 of are commercially tested – Nov 2019