Autism has a 2.5 X higher risk of being severe if poor Vitamin D Binding gene – Nov 2024

---

Impact of gene polymorphisms involved in the vitamin D metabolic pathway on the susceptibility to and severity of autism spectrum disorder

Nature scientific reports volume 14, Article number: 28333 (2024) https://doi.org/10.1038/s41598-024-79994-9
Chanarong Saechua, Tewarit Sarachana, Weerasak Chonchaiya, Pon Trairatvorakul, Wasana Yuwattana, Chayanit Poolcharoen, Montira Sangritdech, Thanit Saeliw, Marlieke Lisanne van Erp, Siriporn Sangsuthum, Natthakul Akarapredee, Sayanit Tipnoppanon, Rattanaporn Sukprasong, Patompong Satapornpong, Chalirmporn Atasilp, Chonlaphat Sukasem & Natchaya Vanwong

This study explores the association between genetic variations in the vitamin D pathway and autism spectrum disorder (ASD) susceptibility and severity in Thai children. A total of 276 participants, including 169 children with ASD and 107 healthy controls, were recruited. Genotyping of vitamin D pathway genes (CYP2R1, CYP27B1, GC, and VDR) was conducted using TaqMan-based real-time PCR, while serum vitamin D levels were measured by chemiluminescence immunoassay. ASD severity was assessed via the Childhood Autism Rating Scale, 2nd Edition. Results reveal that the VDR gene (ApaI) rs7975232 is linked to a reduced ASD risk. In contrast, the GC gene rs7041 (A > C) polymorphism shows a significant association with increased ASD risk and severity, particularly in individuals with both the GC gene polymorphism and vitamin D insufficiency. Additionally, there was a higher prevalence of the GC1s isoform and GC1s-GC1s haplotype in children with ASD, associated with ASD severity. This study identified that individuals possessing GC rs7041 C alleles and the GC1s genotype (rs7041C/rs4588G) exhibit an increased susceptibility to and more severity of ASD. Further studies with larger cohorts are essential to fully understand these genetic polymorphisms’ roles.
 Download the PDF from VitaminDWiki

---

VitaminDWiki – Autism category contains:

Autism category has 167 items

 - see also Overview Autism and vitamin D,  Autoimmune ,   Cognitive,    ADHD
Interesting Autistic studies
Autism associated with low Vitamin D

• Most Autism Risk factors are associated with low vitamin D - March 2014
• Rickets – 26 percent had autism: no rickets, no autism (both associated with low vitamin D) – June 2015
• Autistics have half of the response to Vitamin D – RCT Oct 2018
• Vitamin D fights autism - trying to figure out how and why – May 2022

Autism TREATED by Vitamin D

• Autism in children reduced by Vitamin D (used 300 IU per kg per day) – RCT Oct 2016
• Autism treated by Vitamin D (monthly injection of 150,000 IU) – June 2017
• Autism decreased in 8 out of 10 children supplemented with vitamin D – April 2015

Autism PREVENTED by vitamins before and during pregnancy

• Autism risk is reduced by Vitamin D – early pregnancy or chlldhood – Umbrella review – July 2024
• Vitamin D and autism - treat: 300 IU per kg per day, prevent: during pregnancy 5,000 IU – Feb 2017
• Autism reduced 24% for each 4 ng more Vitamin D while pregnant ( ADHD 12%) – Feb 2024
• Autism rate cut in half when multivitamins (including vitamin D) used during pregnancy – Oct 2017
• Autism risk reduced 2X by prenatal vitamins (Vitamin D or Folic) – Feb 2019
• Autism 3X more likely after closely spaced pregnancy vs 3 year apart– Jan 2011
• Low Vitamin D decreases fertility and increases subsequent autism, ADHD, etc – Feb 2018
• Women who had supplemented with any vitamins were 6 X less likely to have autistic offspring – Jan 2018
• Autism rate in siblings reduced 4X by vitamin D: 5,000 IU during pregnancy, 1,000 IU to infants – Feb 2016

Autism and Vitamin D Receptor (not enough Vit D gets to the cells)
This list is automatically updated

Autism - other risk factors

• Autistic symptoms reduced by Vitamin D and or Omega-3 – RCT March 2019
• Autism risk increased if infant had antibiotics (2X), acetaminophen (3X), or no vitamin D drops (1.5X) – June 2018
• 20 X more Parkinson's and 100X more Autism with GMO soy in China
  • Note >100X increase in Autism while having GMO soy in the US

7 Autism and Virus/Vaccines

Dr. Cannell on Autism and Vitamin D in VitaminDWiki

• Autism treated by Vitamin D (80 – 120 ng) – Cannell update May 2018
• Autism Causes, Prevention and Treatment: Vitamin D Deficiency etc. – Book April 2015 Cannell
• Autism cured in a child with Vitamin D, Dr. Cannell comments and cofactor recommendations – March 2015
• Autism and Vitamin D - Dr. Cannell in Life Extension Mag - Jan 2014
• Autism treated by Vitamin D: Dr. Cannell - video June 2013
  • includes his list of 27 reasons to associate Vitamin D with Autism in 2013

7 studies: Autism reduced by Omega-3

---

VitaminDWiki – Vitamin D Binding Protein category listing has 178 items and the following introduction

Vitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,

• GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
• The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
• The actual D getting to the cells is a function of measured D and all 4 genes
• There is >2X increase in 8+ health problems if have poor VDBP (GC)
• It appears that VDBP only blocks oral vitamin D,
  • but NOT Vitamin D from sun, UV, topical or inhaled (tissue activated)
  • A clue: - Vitamin D from UV is 2X better for MS than oral Vitamin D

---

VitaminDWiki – Vitamin D Binding Protein has a list of health problems

Increased Risk	Health Problem
11 X	Preeclampsia
6.5X	T1D in SA Blacks
6 X	Food Allergy
5 X	PTSD
4 X, 5X	Kidney Cancer
4 X	Poor Response to Oral Vitamin D
3 X	Ear infection
2.8 X	MS
2.5 X	Severe Autism
2 X	Colorectal Cancer
2 X	Prostate Cancer -in those with dark skins
1.3 X	Infertility

---