Dark-skinned people have low vitamin D (Obese pregnant women in UK in this case) – Sept 2024

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Vitamin D status of pregnant women with obesity in the UK and its association with pregnancy outcomes: a secondary analysis of the UK Pregnancies Better Eating and Activity Trial (UPBEAT) study

Br J Nutr . 2024 Jul 14;132(1):40-49. doi: 10.1017/S0007114524000862
Karen M O'Callaghan # 1, Katarzyna G Nowak # 2 3, Kathryn V Dalrymple 1, Lucilla Poston 3, Jessica Rigutto-Farebrother 4, Ola F Quotah 2 5, Sara L White # 3 6, Angela C Flynn # 1 7; UPBEAT Consortium

Prenatal vitamin D deficiency is widely reported and may affect perinatal outcomes. In this secondary analysis of the UK Pregnancies Better Eating and Activity Trial, we examined vitamin D status and its relationship with selected pregnancy outcomes in women with obesity (BMI ≥ 30 kg/m2) from multi-ethnic inner-city settings in the UK. Determinants of vitamin D status at a mean of 17 ± 1 weeks' gestation were assessed using multivariable linear regression and reported as percent differences in serum 25-hydroxyvitamin D (25(OH)D). Associations between 25(OH)D and clinical outcomes were examined using logistic regression. Among 1089 participants, 67 % had 25(OH)D < 50 nmol/l and 26 % had concentrations < 25 nmol/l. In fully adjusted models accounting for socio-demographic and anthropometric characteristics, 25(OH)D was lower among women of Black (% difference = -33; 95 % CI: -39, -27), Asian (% difference = -43; 95 % CI: -51, -35) and other non-White (% difference = -26; 95 % CI: -35, -14) ethnicity compared with women of White ethnicity (n 1086; P < 0·001 for all). In unadjusted analysis, risk of gestational diabetes was greater in women with 25(OH)D < 25 nmol/l compared with ≥ 50 nmol/l (OR = 1·58; 95 % CI: 1·09, 2·31), but the magnitude of effect estimates was attenuated in the multivariable model (OR = 1·33; 95 % CI: 0·88, 2·00). There were no associations between 25(OH)D and risk of preeclampsia, preterm birth or small for gestational age or large-for-gestational-age delivery. These findings demonstrate low 25(OH)D among pregnant women with obesity and highlight ethnic disparities in vitamin D status in the UK. However, evidence for a greater risk of adverse perinatal outcomes among women with vitamin D deficiency was limited.

Clipped from PDF
Women were excluded if unwilling or unable to provide informed consent, or if they had preexisting diabetes, hypertension, renal disease, systemic lupus erythematous, antiphospholipidsyndrome, sickle cell disease, thalassemia, celiac disease, thyroid disease, current psychosisor currently prescribed metformin.
 Download the PDF from VitaminDWiki

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VitaminDWiki - 24 studies in both categories Dark Skin and Obesity

This list is automatically updated

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VitaminDWiki - Dark skin pregnancies and Vitamin D - many studies

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Statistics for African-American vs white births in the US:

• 2X more likely to be premature
• 2X more likely for infant to die in first year – African-American medical risks has chart
• 4X higher maternal mortality rate
• 1.25X more cesarean delivery
• Suspect statistics worse if
  live far from equator
  have more African Ancestry – Vitamin D blood levels vary with estimated amount of African Ancestry – Sept 2010
  Obese
    Fat captures vitamin D – leaving less in the bloodstream
    Overweight sunbathe less - 2009
  Wear clothing which restricts access to sun (Burka, etc)