Less vitamin D gets to cells as you age - fewer Vitamin D Receptors - 2004

Vitamin D Receptor Expression in Human Muscle Tissue Decreases With Age
HA Bischoff-Ferrari,1,2 M Borchers,3 F Gudat,4 U Du¨rmu¨ller,4 HB Sta¨helin,5 and W Dick1
heike.bischoff at usz.ch
JOURNAL OF BONE AND MINERAL RESEARCH Volume 19, Number 2, 2004

 Download the PDF from VitaminDWiki

744 publications cite that study as of July 2023 some of which follow

• Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials
• Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials
• Vitamin D physiology - Lips
• The vitamin D epidemic and its health consequences - Holick
• Effect of vitamin D supplementation on muscle strength, gait and balance in older adults: a systematic review and meta‐analysis
• Vitamin D and human skeletal muscle
• Monthly high-dose vitamin D treatment for the prevention of functional decline: a randomized clinical trial
• Optimal vitamin D status: a critical analysis on the basis of evidence-based medicine
• Recovery after unilateral knee replacement due to severe osteoarthritis and progression in the contralateral knee: a randomised clinical trial comparing daily …
• The effect of vitamin D supplementation on lower-extremity power and function in older adults: a randomized controlled trial
• Skeletal muscle performance and ageing
• Non-musculoskeletal benefits of vitamin D
• Variations in the vitamin D receptor gene are not associated with measures of muscle strength, physical performance, or falls in elderly men. Data from MrOS Sweden - 2019
• Potential cellular and biochemical mechanisms of exercise and physical activity on the ageing process
• The effect of vitamin D supplementation on lower-extremity power and function in older adults: a randomized controlled trial - 2019

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Searched Google Scholar for "vitamin D receptor" (age OR elderly)

• Caffeine intake increases the rate of bone loss in elderly women and interacts with vitamin D receptor genotypes - 2001
• Evidence of an age-related decrease in intestinal responsiveness to vitamin D: relationship between serum 1,25-dihydroxyvitamin D3 and intestinal vitamin D receptor concentrations in normal women - 1992
• Quadriceps and Grip Strength Are Related to Vitamin D Receptor Genotype in Elderly Nonobese Women - 2009
• Prediction of bone density from vitamin D receptor alleles - 1994
• Association Between Intestinal Vitamin D Receptor, Calcium Absorption, and Serum 1,25 Dihydroxyvitamin D in Normal Young and Elderly Women - 2009
• Are vitamin D receptor polymorphisms associated with bone mineral density? A meta‐analysis - 1996
• Relationship between vitamin D receptor gene polymorphism and susceptibility to chronic kidney disease and periodontal disease in community‐dwelling elderly - 2018
• The vitamin d receptor expression in skeletal muscle of women with distal radius fracture - June 2018

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Vitamin D Receptor category in VitaminDWiki has the following

541 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 49 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
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The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (24 studies), Colon Cancer (14 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (25 studies), Hypertension (9 studies), Infant (22 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (16 studies), Obesity (17 studies), Pregnancy (25 studies), Rheumatoid Arthritis (11 studies), TB (8 studies), VIRUS (40 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

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55 health problems associated with poor VDR

A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

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How to increase VDR activation

Compensate for poor VDR by increasing one or more:

Increasing	Increases
1) Vitamin D supplement  Sun Ultraviolet -B	Vitamin D in the blood and thus in the cells
2) Magnesium	Vitamin D in the blood  AND in the cells
3) Omega-3	Vitamin D in the cells
4) Resveratrol	Vitamin D Receptor
5) Intense exercise	Vitamin D Receptor
6) Get prescription for VDR activator    paricalcitol, maxacalcitol?	Vitamin D Receptor
7) Quercetin (flavonoid)	Vitamin D Receptor
8) Zinc is in the VDR	Vitamin D Receptor
9) Boron	Vitamin D Receptor ?, etc
10) Essential oils e.g. ginger, curcumin	Vitamin D Receptor
11) Progesterone	Vitamin D Receptor
12) Infrequent high concentration Vitamin D Increases the concentration gradient	Vitamin D Receptor
13) Sulfroaphane and perhaps sulfur	Vitamin D Receptor
14) Butyrate especially gut	Vitamin D Receptor
15) Berberine	Vitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR

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Increased risk of diseases if poor VDR

Increased risk associated with a poor Vitamin D Receptor
   Note: Some diseases reduce VDR activation
those with a * are known to decrease activation

Risk increase	Health Problem
50	Lyme Disease *
28	Leprosy - another says 3X
15	Chronic Heart Failure
15	Temporary hair loss
14.7	Childhood solid cancers
14	Hand, Foot, and Mouth disease
13	Sepsis
12	COVID Death
11	Metabolic Syndrome
9.6	Chronic Periodontitis    and smoke
8	Juvenile Rheumatoid Arthritis
8.0	Preterm birth
7.6	Crohn's disease
7.5	Respiratory Tract Infections
7.0	Lung Cancer
5.8	Low back pain in athletes
5	Respiratory Distress in preemies
5	Ulcerative Colitis
5	Coronary Artery Disease
5	Asthma Child see also 1.3, 2.0 and 3.7
4.6	Breast Cancer * 16.9 X another study
4.3	Severe COVID in kids
4.1	Vitiligo
4	Liver Cirhosis
4	Polycystic ovary syndrome
3.8	Lupus
3.6	Pneumonia - children
3.3	Pre-term birth
3.1	Colon Cancer survival
3	Multiple Sclerosis
3	Dengue
3	Waist size
3	Ischemic Stroke
3	Alzheimer’s 9X in women
3	Parkinson’s
3	Gestational Diabetes
2.9	Hand, Foot, Mouth Disease
2.8	Osteoporosis & COPD
2.7	Gastric Cancer
2.6	Lupus in children
2.5	Lumbar Disc Degeneration
2.4	Lung Cancer
2.3	Cardio
2.3	Autism
2.2	Juvenile idiopathic arthritis
2.1	Adolescent idiopathic scoliosis in Asians
2	Obesity
2	Diabetic Retinopathy
2	Parkinson's
2	Wheezing/Asthma see also 5X
2	Melanoma   Non-melanoma Skin Cancers
2	Myopia
2	Preeclampsia
1.9	Uterine Fibroids
1.9	Early tooth decay
1.8	Diabetic nephropathy
1.8	Sleep Apnea
1.6	Diabetes - Type I
1.6	Prostate Cancer while black
1.5	Diabetes -Type II
1.5	Gout
1.5	Pertussis
1.5	Obesity
1.4	Graves Disease
1.4	Rheumatoid arthritis
1.3	Hypertension
1.3	Childhood asthma see also 5X
1.3	Psoriasis in Caucasians
1.3	Tuberculosis

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13 reasons why many seniors need more vitamin D (both dose and level) - July 2023 - includes Vitamin D Receptor

1. Senior skin produces 4X less Vitamin D for the same sun intensity
2. Seniors have fewer vitamin D receptor genes as they age
   Receptors are needed to get Vitamin D in blood actually into the cells
3. Many other Vitamin D genes decrease with age
4. Since many gene activations are not detected by a blood test,
   more Vitamin D is often needed, especially by seniors
5. Seniors are indoors more than when they were younger
   not as agile, weaker muscles; frail, no longer enjoy hot temperatures
6. Seniors wear more clothing outdoors than when younger
   Seniors also are told to fear skin cancer & wrinkles
7. Seniors often take various drugs which end up reducing vitamin D
   Some reductions are not detected by a vitamin D test of the blood
   statins, chemotherapy, anti-depressants, blood pressure, beta-blockers, etc
8. Seniors often have one or more diseases that consume vitamin D
   osteoporosis, diabetes, Multiple Sclerosis, Cancer, ...
9. Seniors generally put on weight as they age - and a heavier body requires more vitamin D
10. Seniors often (40%) have fatty livers – which do not process vitamin D as well
11. Reduced stomach acid means less Magnesium is available to get vitamin D into the cells
12. Vitamin D is not as bioavailable in senior intestines
13. Seniors with poorly functioning kidneys do not process vitamin D as well
14. Glutathione (which increases Vitamin D getting to cells) decreases with age
       Seniors category has 436 items