Asthma worse if lower Vitamin D

Are 25(OH) D concentrations associated with asthma control and pulmonary function test?

Caspian J Intern Med. 2019 Fall;10(4):377-382. doi: 10.22088/cjim.10.4.377.

Uzer F1, Ozbudak O2.

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BACKGROUND:

The relationship between vitamin D and asthma is still under investigation. We aimed to evaluate the association between serum vitamin D levels and clinical characteristics of asthma, and the impact of vitamin D deficiency on the clinical manifestations, as them being the issues of debate.

METHODS:

Patients who were admitted to the outpatient clinics of Chest Diseases Department of Akdeniz University Hospital between January 2014 and December 2014, have been diagnosed as asthma according to the GINA 2014 guidelines were included in this study. Subjects with COPD, bronchiectasis, pneumonia or tuberculosis were excluded. Asthma exacerbation was defined, according to the GINA guidelines, as episodes of progressive shortness of breath, cough, wheezing or chest tightness accompanied by PFT abnormalities such as decreased PEF or FEV1.

RESULTS:

A total of 158 patients with mean age of 48.8 years were included in the study. Twenty-seven (17.08%) of the patients demonstrated sufficient vitamin D serum levels (i.e. ≥30 ng/mL), while the remaining 131 (82.92%) patients had vitamin D insufficiency (i.e. <30 ng/mL). When these two patient groups (vitamin D sufficient vs. insufficient) were compared with each other, the patients showing sufficient levels of vitamin D were found to reveal significantly higher FEV1 (L) and FVC (L) values. When the patients were grouped into 4 categories with regard to their serum vitamin D measurements, hospitalization numbers were found to significantly increase with decreasing vitamin D levels.

CONCLUSION: Vitamin D deficiency was significantly associated with poorer pulmonary functions and higher hospitalization numbers.

Asthma 2.8 X less likely to be controlled if low vitamin D - Dec 2025

Vitamin D deficiency and asthma morbidity in school-age children: a single-center cohort study

Front Public Health 2025 Dec 15:13:1717912. doi: 10.3389/fpubh.2025.1717912. eCollection 2025.

Lijuan Dong 1, Yan Li 1

Background: Asthma remains a major cause of morbidity among school-age children worldwide, with deficiency of vitamin D increasingly recognized as a modifiable factor influencing immune regulation and respiratory health. However, evidence on its association with asthma control and exacerbation patterns in pediatric populations is limited, in low- and middle-income population.

Methods: A retrospective single-center study of 320 children, 6-14 years, diagnosed with asthma between January 2019 and December 2023. Following application of inclusion and exclusion criteria, 210 children were analyzed. Data were obtained from medical records and structured questionnaires, including socio-demographic characteristics, asthma control status, exacerbation frequency, hospitalization history, and biochemical assays (serum vitamin D, calcium, phosphate, parathyroid hormone). Patients were categorized as vitamin D deficient, insufficient, or sufficient. Statistical analyses, including χ2 tests, ANOVA, and multivariable logistic regression, were performed using R (v4.3.2).

Results: Vitamin D deficiency was prevalent in 45.2% of children, while 31.0% were insufficient and 23.8% sufficient. Poor asthma control was more common among deficient children (63.2%) compared to insufficient (43.1%) and sufficient groups (24.0%). The mean annual exacerbation rate was highest in the deficient group (2.6 ± 1.3) vs. insufficient (1.9 ± 1.1) and sufficient groups (1.1 ± 0.9). Hospitalization rates also differed significantly (31.6, 18.5, and 12.0%, respectively; p = 0.014). Multivariable logistic regression confirmed that vitamin D deficiency independently predicted poor asthma control (adjusted OR: 2.8, 95% CI: 1.6-4.9, p < 0.001) after adjustment for age, sex, BMI, and treatment profile.

Conclusion: Vitamin D deficiency is highly prevalent among school-age children with asthma and is independently associated with poor control, higher exacerbation frequency, and increased hospitalizations. As part of integrated pediatric asthma care, these findings emphasize the significance of routine screening and the need to take vitamin D supplements into account. At the public health level, targeted nutritional interventions may reduce disease burden and improve long-term outcomes in children.

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Asthma worse if lower Vitamin D

Are 25(OH) D concentrations associated with asthma control and pulmonary function test?

Asthma 2.8 X less likely to be controlled if low vitamin D - Dec 2025

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