Three monthly doses of 150,000 IU of oral cholecalciferol correct vitamin D deficiency in adolescents: a pragmatic study
Int J Clin Pract. 2021 Oct 28;e14989. doi: 10.1111/ijcp.14989
Magdalini Patseadou 1 2, Dagmar M Haller 1 3
Note: Vitamin Dlevels to not remain restored if they are not followed by on-going maintenance dosing
50,000 IU of vitamin D once every two weeks is popular
Youth category
Youth category listing has- Vitamin D for Adolescents - review 2019
- Vitamin D levels in teens restored with 150,000 IU monthly for 3 months (mean 33 ng) – Oct 2021
- 2,000 IU of vitamin D daily helped 80 percent of adolescents – Dec 2020
- Do teens need just 10 ng or up to 60 ng of vitamin D – Review Nov 2019
- Metabolic Syndrome in Chinese youths 2.5 X more likely if less than 20 ng of vitamin D – Sept 2018
- Low levels of Vitamin D in UAE juveniles (virtually none had 30 ng) – Jan 2018
- Reasons for children having low vitamin D (proposed by 10 societies) - May 2018
- Vitamin D restored in teens by doses totalling 300,000 IU – Nov 2014
- Multiple Sclerosis increasing in teens – at least 2X in 9 years
- Majority of adolescents have far less than optimum vitamin D levels – Oct 2017
- Many US kids have less than 40 ng of Vitamin D – 99 out of 100 blacks, 91 out of 100 whites – Jan 2017
- Takes a year to restore children and youths to good levels of vitamin D without loading dose - RCT Dec 2016
- Slow walking speed of youths 14 times more likely if low vitamin D - Dec 2016
Items in both categories Non-daily intervention and Youths:
- Depression cost-effectively reduced by 50,000 IU of Vitamin D monthly (Iranian teens) – July 2023
- Vitamin D levels in teens restored with 150,000 IU monthly for 3 months (mean 33 ng) – Oct 2021
- 450,000 IU of vitamin D over 9 weeks given to 100,000 teenage Iranian girls helped their livers – Feb 2019
- 5,000 IU daily or 50,000 IU Vitamin D weekly repleted many dark skinned adolescents – RCT Dec 2015
- Vitamin D restored in teens by doses totalling 300,000 IU – Nov 2014
- Muscle strength in youth increased with 60,000 IU vitamin D per week and 1 g Calcium – April 2010
Items in both categories Loading dose and Youths:
- Critically ill children – randomized clinical trial to give single doses of up to 400,000 IU of vitamin D – 2019
- Takes a year to restore children and youths to good levels of vitamin D without loading dose - RCT Dec 2016
- Rapid Normalization of Vitamin D in Critically Ill Children (10,000 IU per kg) – clinical trial
- Vitamin D loading doses of up to 400,000 IU OK for adolescents – meta-analysis Dec 2014
- Vitamin D restored in teens by doses totalling 300,000 IU – Nov 2014
- 600000 IU dose raised youth vitamin D level by 60 ng in 3 days – July 2010
Optimum category starts with
The RDA is barely enough for the bones to survive.
Need an optimal level for the body to thrive
Example pages
- Is 50 ng of vitamin D too high, just right, or not enough
- Revisiting Vitamin D Guidelines – Holick Oct 2024 has
- Saudi study defines normal Vitamin D level to be 50 to 70 ng (diabetes, etc.) - June 2020
- Need 40 to 60 ng of Vitamin D – 48 scientists call for action – 2015
- Vitamin D RDA of 600 IU is not enough - global RCT meta-analysis March 2019
- Vitamin D sufficiency 10 to 30 ng, optimal 40 to 80 ng (no consensus)– May 2018
- 4 X fewer visits to Dr. after getting high level of vitamin D (Interview with transcript) - Jan 3, 2022
- Vitamin D sufficiency 10 to 30 ng, optimal 40 to 80 ng (no consensus)– May 2018
- Sports benefits from up to 50 ng of Vitamin – meta-analysis - Nov 2012
- Vitamin D of 32 to 60 ng is needed before, during, and after pregnancy – Dec 2012
- Hypothesis by VitaminDWiki – Vitamin D levels are no longer limited by evolution
- VitaminDWiki pages with HIGH-DOSE in title 878 as of Nov 2024
VitaminDWiki - Weekly, Monthly Vitamin D are typically better than daily - many studies
Objectives: To assess the efficacy of an oral high-dose cholecalciferol regimen in correcting vitamin D deficiency (VDD) in adolescents and to explore potential predictive factors on the response to treatment.
Methods: This is a retrospective chart review conducted in the Adolescent Outpatient Clinic, Geneva University Hospitals, Switzerland. One hundred-three otherwise healthy vitamin D deficient [serum 25hydroxyvitamin D, 25(OH)D, level < 50 nmol/L] adolescents (mean age 16.6) attending the clinic between 1st January 2016 and 31st December 2018 received 150,000 IU of oral cholecalciferol every month for 3 months (cumulative dose of 450,000 IU). We measured the change in serum 25(OH)D levels pre- and post-treatment and the achievement of serum 25(OH)D level post-treatment ≥ 75 nmol/L.
Results: The mean serum 25(OH)D level increased by 320 %, from 26 nmol/L at baseline to 83 nmol/L at the end of the study (p < 0.001). The rise was significantly higher for patients initially tested in the winter/spring (mean 65 nmol/L) compared to those initially tested in the summer/autumn (mean 48 nmol/L) (p < 0.003). No clear relationship was found between the response to treatment and the vitamin D status at baseline. The effect of age, gender, origin and body mass index was not statistically significant.
Conclusions: The present intermittent high-dose regimen is effective in treating VDD in healthy adolescents without significant variations in response between different subgroups.
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