Small for gestational age birth was 6.5X more likely if mother was vitamin D deficient – March 2015

Maternal vitamin D deficiency during pregnancy elevates the risks of small for gestational age and low birth weight infants in Chinese population.

J Clin Endocrinol Metab. 2015 Mar 16:jc20144407. [Epub ahead of print]
Chen YH1, Fu L, Hao JH, Yu Z, Zhu P, Wang H, Xu YY, Zhang C, Tao FB, Xu X.

CONTEXT:
Vitamin D deficiency is common in the pregnant women. Nevertheless, the association between maternal vitamin D status during pregnancy and the risks of small for gestational age (SGA) and low birth weight (LBW) infants is uncertain.

OBJECTIVE: The objective of this study was to investigate whether maternal vitamin D deficiency during pregnancy and the risks of SGA and LBW infants in Chinese population.

DESIGN AND PARTICIPANTS: This study was a population-based birth cohort study that recruited total 3658 eligible mother-and-singleton-offspring pairs.

MAIN OUTCOME MEASURES: Serum 25(OH)D was measured by radioimmunoassay. The rate and relative risk (RR) for SGA and LBW infants were calculated among subjects with vitamin D deficiency and insufficiency during pregnancy.

RESULTS:
There was a positive correlation between maternal serum 25(OH)D level and offspring birth weight (r=0.477, P<0.001). Further analysis showed that 4.98% neonates were LBW infants among subjects with vitamin D deficiency (RR: 12.00; 95%CI: 4.37, 33.00) and 1.32% among subjects with vitamin D insufficiency (RR: 3.18; 95%CI: 1.07, 9.48). After adjustment for confounders, RR for LBW infants was 12.31 (95%CI: 4.47, 33.89) among subjects with vitamin D deficiency and 3.15 (95%CI: 1.06, 9.39) among subjects with vitamin D insufficiency. Moreover, 16.01% neonates were SGA infants among subjects with vitamin D deficiency (RR: 5.72; 95%CI: 3.80, 8.59) and 5.59% among subjects with vitamin D insufficiency (RR: 1.99; 95%CI: 1.27, 3.13).
After adjustment for confounders, RR for SGA infants was 6.47 (95%CI: 4.30, 9.75) among subjects with vitamin D deficiency and 2.01 (95%CI: 1.28, 3.16) among subjects with vitamin D insufficiency.

CONCLUSION: Maternal vitamin D deficiency during pregnancy elevates the risks of SGA and LBW infants in Chinese population.

PMID: 25774884
 Download the PDF from VitaminDWiki

---

See also VitaminDWiki

• Boys who were born Small for Gestational age are 1.9X more likely to be infertile – Dec 2019
• Pregnancy complications from 3 to 55 X more likely to have these health problems if low Vitamin D
  7 X more likely to have low birth weight infant very similar to 6.5X of study on this page
• Low birth weight far more likely if African-American (low vitamin D) – 1997, Aug 2018
• Births with low vitamin D weighted less (Hispanic too) – Dec 2015
• Healthy pregnancies need lots of vitamin D
  13 health pregnancy/child health problems associated with low vitamin D
• Half as many Small for Gestational Age infants when take 600 IU of vitamin D while pregnant – June 2018
• (Stunting OR “low birth weight” OR LBW) 277 items as of March 2015
• Overview Pregnancy and vitamin D
• Low vitamin D increased probability of low birth weight by 60 percent – meta-analysis June 2012

Pregnancy category listing has 923 items along with related searches

See also Web

More SGA for darker skins (less vitamin D)

Wikipedia on Large, Appropriate, and Small for Gestational Age

PREGESTATIONAL DIABETES MELLITUS AND PREGNANCY 1999

SGA High mortality before, within a month, and within a few weeks of birth but including still birth (Vertical axis = %)_