Male vitamin D status and male factor infertility
Fertil Steril. 2021 Jul 18;S0015-0282(21)00535-5. doi: 10.1016/j.fertnstert.2021.06.035 $36 0aywall
Nicole Banks 1, Fangbai Sun 2, Stephen A Krawetz 3, R Matthew Coward 4, Puneet Masson 5, James F Smith 6, J C Trussell 7, Nanette Santoro 8, Heping Zhang 2, Anne Z Steiner 9
Fertility and Sperm category contains the following summary
See also:
Overview Women and Vitamin D
Overview Pregnancy and vitamin D Fertility and Vitamin D – several articles
Endometriosis
Ensure a healthy pregnancy and baby - take Vitamin D before conception
IVF OR "IN VITRO FERTILIZATION" etc. in 18 VitaminDWiki titles
Vitamin D greatly improves Fertility
- Vitamin D is needed for human fertility – goal is 50 ng – Sept 2018
- In-vitro Fertilization costs at least 10,000 dollars, Vitamin D costs 5 dollars
- Women were 50X more likely to be fertile if just 1 ng higher level of vitamin D – Nov 2024
- Infertile patients 1.7X more-likely to become pregnant if take Vitamin D – meta-analysis Feb 2023
- Live birth 1.7 X more likely after IVF if good level of vitamin D – meta-analysis Aug 2020
- If diagnosed infertile, more likely to have live birth if Vitamin D fortification – Feb 2020
- Preconception vitamin D is great - every extra 10 ng associated with 10 percent more likely to have live birth – Aug 2018
- Women with more than minimum vitamin D were 3.4 X more likely to achieve pregnancy and 1.6 X more likely to have live births – June 2017
- Assisted Reproduction – 5 studies concluded vitamin D repletion helps – Review March 2015
- Pregnancy success increased 30 percent if sunny (or vitamin D) one month earlier – June 2015
- IVF 4X more successful for white women with lots of vitamin D – many studies
Increased male Vitamin D increases fertility
- Birth rates doubled with Vitamin D - 300,000 for infertile men – RCT Nov 2017
- Higher vitamin D results in 22% fewer abnormal sperm (Mendelian analysis) – May 2024
- Conception was 3.7X more likely if the male had a good level of Vitamin D – July 2022
- Far better sperm in fertility clinic if more than 30 ng of Vitamin D - June 2022
- Fertility (sperm) associated with vitamin D – meta-analysis Sept 2019
- Infertility - 71 percent of the time of BOTH partners had less than 20 ng of Vitamin D – Aug 2017
- Male fertility 4 X higher if high Vitamin D – Nov 2015
- Vitamin D somewhat assists reproduction – both the mother and the father – May 2014
Decreased Fertility if decreased Vitamin D Receptor
- Unexplained infertility 4X more likely if poor vitamin D receptor – Dec 2020
- Male Infertility is associated with poor Vitamin D Receptor – July 2021
Trends in Self-reported Spontaneous Abortions: 1970–2000 - Aug 2012
- "After accounting for abortion availability and the characteristics of pregnant women, the rate of reported miscarriages increased by about 1.0% per year. "
Download the PDF from VitaminDWiki
Speculation by VitaminDWiki: Might the increased miscarriage rate be associated with decreased Vitamin D levels?
Apparently: Pregnancy loss =miscarriage = spontaneous abortion (up to 20 weeks gestation)
VitaminDWiki pages containing PREGNANCY LOSS or MISCARRIAGE in title
Why all companies should offer leave for pregnancy loss Fast Company July 2021
- "A 2020 study found that one in six women who have a miscarriage or an ectopic pregnancy suffer from long-term post-traumatic stress. When you consider that anywhere from 10-20% of known pregnancies end in miscarriage, that’s a lot of people who likely end up suffering privately at work, unable to take time off to recuperate."
Objective: To determine the association between vitamin D levels in the male partner and fertility outcomes in couples with mild male factor infertility.
Design: Secondary analysis of a randomized, controlled trial.
Setting: Nine fertility centers in the United States.
Patient(s): Men (n = 154) with sperm concentration between 5 and 15 million/mL, motility ≤40%, or normal morphology ≤4% were eligible. Female partners were ovulatory, ≤40 years old, and had documented tubal patency.
Intervention(s): Men provided semen and blood at baseline for semen analysis and 25-hydroxyvitamin D (25(OH)D) levels. They were randomly assigned to receive a vitamin formulation including vitamin D 2,000 IU daily or placebo for up to 6 months. Couples attempted to conceive naturally during the first 3 months and with clomiphene citrate with intrauterine insemination of the female partner in months 4 through 6.
Main outcome measure(s): Primary: sperm concentration, motility, morphology, and DNA fragmentation at baseline. Secondary: cumulative pregnancy, miscarriage, and live birth rates.
Result(s): Semen parameters and sperm DNA fragmentation were not statistically significantly different between men with vitamin D deficiency and men with 25(OH)D levels ≥20 ng/mL. In addition, clinical pregnancy and live birth rates were similar. Male 25(OH)D level <20 ng/mL was associated with a higher rate of pregnancy loss (adjusted odds ratio 9.0; 95% confidence interval 1.3 to 61.3).
Conclusion(s): Vitamin D deficiency in the male partner did not significantly impact semen parameters or treatment outcomes. Further study is warranted to better characterize the rate of miscarriage in couples with male vitamin D deficiency.
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