No improvement of sleep from vitamin D supplementation: insights from a randomized controlled trial
Sleep Medicine: X Volume 3, December 2021, https://doi.org/10.1016/j.sleepx.2021.100040
A.U.LarsenaL.A.HopstockbR.JordeaG.Grimnesac
Sleep category starts with
A few items in SLEEP category
- Sleep greatly improved by 50,000 IU of vitamin D once every two weeks – RCT Sept 2018
- Sleep disorders nicely treated by Vitamin D (50,000 IU twice a month) – RCT May 2017
- Sleep, Dr. Gominak and Vitamin D - several studies
- Restless Legs Syndrome dramatically reduced by vitamin D, etc
- On the job sleepiness 2.2X more likely if low vitamin D – Feb 2020
- Poor sleep 1.5 X more likely if less than 20 ng of Vitamin D – Feb 2019
- The Better Sleep Vitamin (Vitamin D) – nice 3 dollar book Feb 2015
- The worse the sleep apnea, the lower the vitamin D levels – meta-analysis 2017, 2020
- Vitamin D for better sleep video - Dec 2021
- 5X increase in sleep problems in a decade in US Veterans
- Sleep Apnea and Vitamin D - many studies
- Melatonin and Vitamin D - many studies does much more than improve sleep
- - - - - -
Download the PDF from VitaminDWiki
Background
Vitamin D has been linked to sleep health in observational studies. Data from randomized controlled trials (RCTs) with vitamin D is scarce.
Methods
This study presents the results of a secondary analysis of 189 vitamin D insufficient participants (47.1% women) in a previously performed RCT, of which 92 were randomized to vitamin D (100,000 IU (2500 μg) as a bolus dose followed by 20,000 IU (500 μg) per week), and 97 to placebo. At baseline and after 4 months at the end of the study serum 25-hydroxyvitamin D (s-25(OH)D) was measured, and the study questionnaire assessing sleep duration, daytime sleepiness, and symptoms of insomnia, was completed.
Results
At baseline, mean s-25(OH)D was 35.0 ± 11.8 and 35.5 ± 13.3 nmol/L in the vitamin D and placebo groups, respectively. After four months, we found no statistically significant differences between the intervention groups in any of the assessed sleep outcomes, neither when stratified by sex, nor when performed in subgroups based on baseline or end of study s-25(OH)D level or presence of sleep complaints at baseline.
Conclusions
We were not able to demonstrate a significant effect of vitamin D supplementation on sleep in this vitamin D insufficient population.
There have actually been
| 2418 visitors, last modified 03 Mar, 2022, |