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Leg cramp frequency reduced 2.7 X by 8 weeks of vitamin K - RCT Nov 2024

Medscape
A total of 199 participants aged ≥ 65 years with at least two documented episodes of nocturnal leg cramps during a 2-week screening period were included.
Participants were randomized in a 1:1 ratio to receive either 180 μg of vitamin K (menaquinone 7) or a placebo daily for 8 weeks.
TAKEAWAY:

Vitamin K group experienced a significant reduction in the mean weekly frequency of cramps (mean difference, 2.60 [SD, 0.81] to 0.96 [SD, 1.41]) compared with the placebo group, which maintained a mean weekly frequency of 3.63 (SD, 2.20) (P < .001).
The severity of nocturnal leg cramps decreased more in the vitamin K group (mean difference, −2.55 [SD, 2.12] points) than in the placebo group (mean difference, −1.24 [SD, 1.16] points).
The duration of nocturnal leg cramps also decreased more in the vitamin K group (mean difference, −0.90 [SD, 0.88] minutes) than in the placebo group (mean difference, −0.32 [SD, 0.78] minutes).

See also VitaminDWiki

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Overview Vitamin K and Vitamin D
- RCT 1500 micrograms daily K2 preserves bone - 2013
- Appears that Vitamin K is needed to prevent bone loss - 2012

Leg cramp frequency reduced 2.7 X by 8 weeks of vitamin K - RCT Nov 2024

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