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Variety of evidence that Vitamin D helps the brain – July 2014

Vitamin D as a Neurosteroid Affecting the Developing and Adult Brain

Annual Review of Nutrition, Vol. 34:117-141 - July 2014, DOI: 10.1146/annurev-nutr-071813-105557
Natalie J. Groves,1 John J. McGrath,1,2,3 and Thomas H.J. Burne1,2,  t.burne at uq.edu.au

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https://vitamindwiki.com/tiki-index.php?page_id=8392

Vitamin D deficiency is prevalent throughout the world, and growing evidence supports a requirement for optimal vitamin D levels for the healthy developing and adult brain. Vitamin D has important roles in proliferation and differentiation, calcium signaling within the brain, and neurotrophic and neuroprotective actions; it may also alter neurotransmission and synaptic plasticity. Recent experimental studies highlight the impact that vitamin D deficiency has on brain function in health and disease. In addition, results from recent animal studies suggest that vitamin D deficiency during adulthood may exacerbate underlying brain disorders and/or worsen recovery from brain stressors. An increasing number of epidemiological studies indicate that vitamin D deficiency is associated with a wide range of neuropsychiatric disorders and neurodegenerative diseases. Vitamin D supplementation is readily available and affordable, and this review highlights the need for further research.

Sections include
INTRODUCTION
THE ACTIONS OF VITAMIN D WITHIN THE BRAIN
RODENT MODELS OF VITAMIN D DEFICIENCY
LINKS WITH NEUROPSYCHIATRIC AND NEURODEGENERATIVE DISORDERS
FUTURE DIRECTIONS
CONCLUSION


Google Scholar had 251 studies citing this study as of Dec 2023

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VitaminDWiki pages with BRAIN in title (94 as of Oct 2022)

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Items found: 112
Title Modified
1 % weight loss delays brain aging by nearly nine months - RCT April 2023 28 Jul, 2023
300,000 IU Vitamin D injection before brain tumor surgery – RCT to finish Dec 2017 20 Aug, 2017
33 percent more white matter abnormality in brain (periventricular WMA) if low vitamin D – July 2014 15 Jul, 2014
5 Traumatic brain injuries resulted in 2.8 X increased risk of dementia – April 2018 11 Apr, 2018
60 percent of preemies have brain damage from lack of brain Oxygen, which is associated with low vitamin D – Feb 2018 22 Feb, 2018
Active form of vitamin D directly protects the blood–brain barrier in multiple sclerosis – Aug 2017 26 Aug, 2017
ADHD 4 year-olds – smaller brain regions proportional to ADHD severity – March 2018 26 Mar, 2018
Amyloid brain plaque both prevented and removed by high vitamin D (in mice) – Aug 2018 23 Nov, 2018
Autism has different causes but same inflammation in brain in half of autistics – May 2011 13 Jul, 2013
Autistics and Schizophrenics have 3X lower Vitamin B12 levels in the brain – Jan 2016 01 Oct, 2018
Benefits of Omega-3 on brain development 30 Apr, 2016
Blood–brain barrier dysfunction in multiple sclerosis (improved by vitamin D, etc.) – Jan 2024 16 Dec, 2023
Brain (Alzheimer’s) worked better with Vitamin D intervention – meta-analysis July 2013 05 May, 2014
Brain cancer in 175 countries related to low UVB and low vitamin D – Oct 2010 03 Oct, 2018
Brain cells can probably activate Vitamin D without liver or kidney (at least in rats) – Sept 2017 25 Oct, 2022
Brain injury disability associated with lower vitamin D – Oct 2018 20 Oct, 2018
Brain is helped by Omega-3 during all phases of life – Aug 2018 21 Aug, 2018
Brain lesions might be associated with vitamin D deficiency – March 2012 19 Jan, 2014
Brain may deal with all forms of Vitamin D (rat brain) – Sept 2017 06 Nov, 2017
Brain Plasticity (Posit Science) greatly improves speed, recall 25 Sep, 2023
Brain scans noticed changes in most elderly after COVID infection – March 2022 14 Mar, 2022
Brain Tumor surgery – will previous injection of 300,000 IU Vitamin D help – RCT 2018 29 Dec, 2017
Brains of seniors had 60 percent more white matter abnormalities if low vitamin D – March 2015 25 Feb, 2015
Cognitive decline after traumatic brain injury reduced by Omega-3 (mice) – Nov 2016 06 Dec, 2016
Cognitively impaired brain atrophy was slowed 40 percent by Omega-3 and B vitamins – RCT July 2015 14 Jul, 2015
Concussions (traumatic brain injury) getting big press coverage, vitamin D might be both a cause and a solution 15 Jul, 2023
Dementia risk reduced 29 percent by just 10 hours of computer brain plasticity training – RCT Dec 2017 08 Dec, 2017
Early brain development helped by Iron, Iodine, Vitamin D, Omega-3. Zinc etc. – Oct 2021 08 Oct, 2021
Every Parkinson’s brain had a gene modification that limited how much vitamin D was available (CYP27B1) – Feb 2022 15 Feb, 2022
Fewer days in hospital if 300,000 IU of vitamin D before brain surgery - RCT Feb 2021 25 Jan, 2021
Fewer white spots in MRI brain scans if had more vitamin D – Jan 2014 31 May, 2015
Following brain surgery Vitamin D injections did not raise blood levels much – RCT June 2019 11 Jun, 2019
Following strokes, brain scans (MRI) 3X worse in those having low vitamin D – July 2018 25 Jul, 2018
Football Brain injuries prevented by Omega-3 – RCT Jan 2016 08 Feb, 2016
Fructose altered hundreds of brain genes (in rats) unless also take Omega-3 – April 2016 01 May, 2016
Glioma (brain, spinal cancer) 40 percent less likely if male vitamin D levels were high 15 years earlier – Aug 2015 25 Dec, 2016
Global burden of brain disorders surpasses cardiovascular disease and cancer - July 2023 15 Jul, 2023
High-fructose diet slows recovery from brain injury - TBI, rats - Oct 2015 01 May, 2016
Hypothesis – Brain plasticity improved by Vitamin D – Feb 2019 20 Feb, 2019
Hypothesis: Chemo brain and other cognitive impairements are associated with low vitamin D 09 Jul, 2014
If less than 20 ng then 2X more likely to be fatigued after brain injury - April 2010 05 Nov, 2011
Immune system both activates and uses vitamin D (in brain, fight COVID, etc.) - March 2022 16 Mar, 2022
Infants getting 1 g of Omega-3 for 12 weeks got better brains – RCT March 2017 18 Mar, 2017
Inflammation of small blood vessels in the brain is associated with low vitamin D - April 2023 04 Apr, 2023
Inhaling Vitamin D nanoemulsion through nose gets lots more to the brain (mice) – July 2020 03 Aug, 2020
Less vitamin D, bigger brain - humans and animals - Jan 2015 11 Aug, 2015
Low maternal Vitamin D results in larger portion of brain associated with autism – Jan 2020 07 Jan, 2020
Low vitamin D associated with brain atrophy in MS – April 2010 19 Jan, 2014
Low vitamin D is associated with larger brain – Feb 2014 16 Feb, 2014
Low vitamin D is bad for the rat brain (and probably human brain) – Dec 2013 19 Jan, 2014
Lupus can progress to effect brain and nerves - Jan 2024 05 Jan, 2024
Lymphatic system discovered in brain (what about Multiple Sclerosis, Alzheimer’s, Omega-3 and Vitamin D) – Oct 2017 07 Oct, 2017
Magnesium L-Threonate – tiny amount more bioavailable to brain but far more expensive– June 2016 16 May, 2016
Magnesium may be an important way to treat brain trauma 12 Oct, 2015
Malaria in mice brains, and associated inflammation, prevented by Vitamin D intervention – July 2014 01 May, 2016
Male brains age faster if low vitamin D (perhaps male-pattern baldness fights this) - Oct 2022 31 Oct, 2022
Meningitis and other brain infections should be prevented by Vitamin D – June 2014 25 Feb, 2021
Mild Traumatic Brain Injury prevented with Omega-3, Resveratrol, etc (in rats) – Oct 2017 10 Oct, 2017
Mild Traumatic Brain Injury reduced by Vitamin D – May 2014 07 Aug, 2017
Mutated gene, OAS1, which lowers vitamin D in brain, increases Alzheimers and severe COVID-19 – Oct 2021 15 Oct, 2021
Nerve growth and survival depends on BDNF (Brain-Derived Neurotrophic Factor), which is associated with Vitamin D 19 Nov, 2017
COVID-19 leaves its mark on the brain, dropping in IQs - March 2024 20 Mar, 2024
Brain and Vitamin D - many studies 07 Jan, 2024
Benign Cancers of a portion of the brain increased 1.8 X after vaccines were available - March 2024 24 Mar, 2024
Benign Cancers of a portion of the brain increased 1.8 X after vaccines were available - March 2024 24 Mar, 2024
Off topic: Brain Plasticity (best way to exercise your brain) – Interview Dec 2012 08 Dec, 2017
Off topic: Limbic System and Brain can both be retrained (plasticity) – March 2019 17 Mar, 2019
Omega-3 helps brains of seniors – May 2019 04 Jun, 2019
Omega-3 is important for Brain Health during all phases of life – Aug 2018 08 Dec, 2018
Omega-3: An Intelligent Decision for Brain Nutrition (book chapter) April 2018 24 Apr, 2018
Parkinson disease 2X more likely after brain injury – which usually reduces vitamin D – Nov 2012 13 Nov, 2012
Parkinsons' disease and MRI white matter in brain 25 Feb, 2015
Perhaps drugs such as inhaled vitamin D can get directly to the brain – March 2018 19 Nov, 2018
Poor blood-brain barrier following stroke if low vitamin D (in rats) – RCT Feb 2019 01 Dec, 2018
Recent brain problems appears to be associated with neurofilament light chains (would aide Vitamin D MS. Alz studies) – June 2019 13 Jul, 2019
Restless Leg Syndrome linked to brain genes associated with Vitamin D and Iron – Nov 2019 15 Nov, 2019
Smaller brains (Intracranial Volume) associated with lower vitamin D – July 2018 21 Jul, 2018
Smaller brains associated with low vitamin D (again) – Dec 2022 14 Nov, 2022
Surgeries to re-establish blood in brain, heart, etc. are far more successful with high Vitamin D levels – March 2022 08 Oct, 2022
Sustained brain attention appears to vary with vitamin D levels – March 2016 21 Jan, 2017
The Longevity and Brain Benefits of Vigorous Exercise - Patrick video Dec 2023 05 Dec, 2023
The Role of Vitamin D in Brain Health: A Mini Literature Review – Sept 2018 15 Sep, 2018
Traumatic Brain Injuries routinely treated by Vitamin D, Omega-3, Progesterone and Gluatmine 15 May, 2019
Traumatic Brain Injuries treated by Vitamin D etc (US patent) – interview Dec 2019 25 Dec, 2019
Traumatic Brain Injury – 120,000 IU of Vitamin D resulted in 3 fewer days on ventilators – RCT March 2020 17 Mar, 2020
Traumatic Brain Injury in military - vitamin D - 2014 08 Feb, 2016
Traumatic Brain Injury recovered faster if high vitamin D (review of 58 studies) – April 2021 09 Jun, 2022
Traumatic Brain Injury recovery helped by injection of 100,000 IU of Vitamin D – March 2019 13 May, 2019
Traumatic brain injury treated by Vitamin D Progesterone Omega-3 and glutamine – May 2013 11 Sep, 2016
Variety of evidence that Vitamin D helps the brain – July 2014 25 May, 2019
Vitamin B12 treats Traumatic Brain Injury in mice – April 2019 21 May, 2019
Vitamin D aided progesterone in reducing traumatic brain injury – RCT Dec 2012 03 Jan, 2015
Vitamin D and Brain behaviour - review of 10 years - Jan 2021 10 Mar, 2021
Vitamin D can also fight COVID induced brain problems (behind paywall) – April 2022 04 Apr, 2022
Vitamin D Deficiency a Brain Disruptor - Spring 2019 14 Jun, 2019
Vitamin D improved brains in aging rats – Sept 2014 03 Oct, 2014
Vitamin D levels in the brain vary with both the region and the brain problem – Dec 2022 16 Apr, 2023
Vitamin D levels vary across the brain, what about other body tissues – July 2019 17 Jul, 2019
Vitamin D prevented brain damage by High Fructose corn syrup (in rats) – Feb 2024 07 Dec, 2023
Vitamin D supplementation resulted in thicker Brain Cortex – RCT June 2021 12 Jun, 2021
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Variety of evidence that Vitamin D helps the brain – July 2014        
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