Effect of cholecalciferol on 25-hydroxyvitamin D in people living with HIV and vitamin D deficiency: A prospective observational study
Med Clin (Barc). 2025 May 23;165(2):106972. doi: 10.1016/j.medcli.2025.106972 partial PDF is online
Cristina Tomás 1, Ángeles Muñoz 1, Carlos Báguena 1, Antonia Alcaraz 1, Rodrigo Martínez-Rodríguez 1, María Dolores Hernández 1, María Isabel Martínez 1, Rubén Corral-San-Miguel 1, Eduardo Pons-Fuster López 2, Eva García-Villalba 1, Salvador Valero 1, Eva Oliver Galera 1, Elena Guijarro Westermeyer 1, Román González Hipólito 1, Concepción Corbalán Dólera 3, María Del Carmen García Ros 3, Enrique Bernal 4
Objectives: To assess the effect of oral cholecalciferol 50,000IU monthly administered in people living with HIV (PLHIV) and 25(OH)D deficiency followed over 48 weeks.
Methods: A prospective observational study was conducted in a cohort of 110 PLHIV with 25(OH)D levels<20ng/mL. Changes in 25(OH)D levels were evaluated at 3, 6, and 12 months of treatment. The percentages of patients who achieved 25(OH)D levels>20 and >30ng/mL and changes in bone mineral density (BMD) were assessed.
Results: One hundred ten PLHIV (79% men, mean age 49.46 years) were included. The mean (standard deviation, SD) time on antiretroviral treatment was 10.69 (8.31) years and all patients had a viral load<50copies/mL. The mean 25(OH)D levels of 15.10±3.22ng/mL at baseline increased significantly (P<0.001) to 27.89±7.79ng/mL at 3 months, 28.53±8.45ng/mL at 6 months and 27.89±7.92ng/mL at 12 months. A total of 87.27% had normal 25(OH)D levels at 12 months (>30ng/mL in 36.1% of patients and >20ng/mL in 51.5%). Parathormone levels (PTH) also decreased significantly. Treatment was safe and well tolerated. On the other hand, no significant changes were observed in BMD.
Conclusions: Monthly administration of 50,000IU of cholecalciferol was effective in normalizing 25(OH)D deficiency in 87% of PLHIV, without observing changes in bone mineral density.
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