Vitamin D supplementation reduces Metabolic Syndrome if deficient

Created August 2020

Mechanistic Effects of Vitamin D Supplementation on Metabolic Syndrome Components in Patients with or without Vitamin D Deficiency

Review J Obes Metab Syndr. 2020 Aug 4. doi: 10.7570/jomes20003

Samira Faraji 1 2, Mohammad Alizadeh 2 3

Clipped from PDF: MetS “ … can increase the risk of other diseases, such as a 2-fold increase in risk for cardiovascular disease 2- to 4-fold for stroke 5-fold or more for type 2 diabetes, and 3- to 4-fold for myocardial infarction.” 1. Metabolic Syndrome has the following {include} Items in both categories Metabolic Syndrome and Diabetes are listed here: {category} 1. Items in categories Metabolic Syndrome AND Obesity {category}

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The prevalences of metabolic syndrome (MetS) and vitamin D deficiency are increasing dramatically worldwide. MetS in itself is not a disease but is a major challenge because it can increase the risk of most non-communicable diseases. The beneficial effect of vitamin D on MetS components remains controversial, so the present review focused on the clinical effects of vitamin D supplementation on MetS components.

Vitamin D can inhibit the protein expression of nuclear factor beta; improve arterial stiffness; decrease renin-angiotensin-aldosterone system activity, parathyroid hormone levels, inflammatory cytokines, 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA)-reductase, and lanosterol 14 β-demethylase enzyme activity; increase the activity of lipoprotein lipase; alter gene expression in C2C12 cells; and improve phospholipid metabolism and mitochondrial oxidation. We tried to elucidate and analyze almost all evidence from randomized controlled trial studies of the efficacy of vitamin D supplementation in patients with MetS. The findings of the present study reported beneficial effects of vitamin D supplementation on mentioned factors. Vitamin D supplementation is recommended in people with vitamin D deficiency even if it has no considerable effect on most MetS factors. However, existing data from interventional studies are insufficient to reach a definitive conclusion about the effect of vitamin D supplementation on MetS components in patients without vitamin D deficiency. Thus, new clinical studies are needed to test the hypothesis that vitamin D supplementation could alleviate MetS components in patients with sufficient intake of vitamin D.

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Tags: Deficiency Metabolic Syndrome