Vitamin D helps women in many ways – but not sure about ovarian and endometrial cancer

The association between Vitamin D and health outcomes in women: A review on the related evidence.

J Res Med Sci. 2016 Sep 1;21:76. eCollection 2016.

Jolfaie NR1, Rouhani MH1, Onvani S1, Azadbakht L2.

* Ovarian cancer risk increases 27 percent for each 8 ng lower level of Vitamin D – Sept 2016 * Ovarian Cancer – 7 percent more likely to survive longer for every 4 ng higher vitamin D – July 2015 * Ovarian Cancer re-occurrence 50 percent more likely if still low vitamin D – Sept 2015 * Vitamin D helps women in many ways – review April 2015 * ALL of the top 10 health problems of women are associated with low vitamin D * Women **category listing has items along with related searches and the following chart** * Majority of a woman's health problems are associated with low vitamin D

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BACKGROUND:

Vitamin D has a wide range of physiological functions in skeletal and nonskeletal tissues which may play a role in many diseases. The aim of this study was to evaluate the recent evidence regarding the effects of Vitamin D on several health outcomes in women including breast cancer, ovarian and endometrial cancers, hypertension, and osteoporosis.

MATERIALS AND METHODS:

We searched PubMed and Google Scholar databases through March 2016. We included the most current systematic reviews and meta-analyses assessing the associations of Vitamin D intake and/or serum 25-hydroxyvitamin D (25(OH)D) levels with the risk of incidence of breast cancer, ovarian and endometrial cancers, hypertension, and osteoporosis.

RESULTS:

Many studies have represented that Vitamin D supplementation and high 25(OH)D levels can decrease the risk of breast cancer occurrence or mortality. However, there is no strong evidence to support the existence of a relationship between Vitamin D and ovarian or endometrial cancers. Furthermore, the results regarding the effects of Vitamin D on hypertension were inconsistent. Although observational studies have shown an association between Vitamin D and hypertension, there is no evidence regarding effectiveness of Vitamin D in lowering blood pressure in several clinical trials. On the other hand, the findings associating the impact of Vitamin D on osteoporosis were more definitive and most studies have represented that Vitamin D may have beneficial effects on osteoporosis.

CONCLUSION:

Although the adequate Vitamin D level can play a protective role in the incidence and development of breast cancer, hypertension, and osteoporosis, there is limited evidence regarding ovarian and endometrial cancers.

PMID: 27904621 DOI: 10.4103/1735-1995.189693