Vitamin D for infections and COVID (50,000 IU weekly for 3 months)

The Relationship Between Vitamin D and Infections Including COVID-19: Any Hopes?

International Journal of General Medicine 2021:14 3849-3870

Rbab Taha ©'. Shahd Abureesh ©. Shuruq Alghamdi 2 Rola Y Hassan Mohamed M Cheikh 4,5 Rania A Bagabir6 Hani Almoallim©2’7 Altaf Abdulkhaliq 8 'Department of Transplant Infectious Disease, University Health Network, Toronto, Ontario, Canada; 2Department of Medicine, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia; 3Department of Internal Medicine, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia; 4Department of Internal Medicine, Doctor Soliman Fakeeh Hospital, Jeddah, Saudi Arabia; 5Department of Medicine, Fakeeh College for Medical Sciences, Jeddah, Saudi Arabia; 6Department of Immunology and Hematology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia; 7Alzaidi Chair of Research in Rheumatic Diseases, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia; 8Department of Clinical Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia

Table of Contents

1. Immune systems helped by 50,000 IU of vitamin D (weekly for 3 months) – May 2021 Most, but not all, responded well to the intervention Starting with a loading dose of 50,000 IU daily for a week or 350,000 IU in a single day would have reduced the time from 3 months to <2 weeks * Vitamin D restoration then monthly was the most popular dosing by trials – Nov 2018 * Elderly Vitamin D Loading Dose of 500,000 IU is safe and effective – RCT 2009 * Vitamin D loading dose (stoss therapy) proven to improve health --- 1. Immunity category starts with: {include} 1. COVID-19 treated by Vitamin D - studies, reports, videos * {include} 1. Items in BOTH categories Immunity and Virus: {category} --- 50,000 IU weekly helped >18 health problems VitaminDWiki pages containing "50,000" in title 163 as of Dec 2021

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Vitamin D is proposed to have a potential role in the pathogenicity, clinical presentation, prognosis, complications, and treatment of several diseases. In addition to its well-known role in calcium metabolism, vitamin D regulates both innate and adaptive immunity, and subsequently modulates the antiviral and antibacterial inflammatory immune responses. In view of the emerging coronavirus disease 2019 (COVID-19) pandemic, searching for potential therapeutic and protective strategies is of urgent interest, and vitamin D is one of the promising agents in this field. In this review, we present data from literature that supports the promising role of vitamin D in treatment and/or prevention of several infections including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

This review summarizes vitamin D metabolism and its role in inflammation, thrombosis and immune regulation. It also reviews, in short, the role of vitamin D and the impact of its deficiency in several infections namely tuberculosis, influenza, human immunodeficiency virus (HIV), and SARS-CoV-2. Considering the roles of vitamin D on immune modulation, controlling of thrombosis, and attacking several microorganisms, the current review will elaborate on the association between these salient roles of vitamin D and the pathogenicity of various infectious agents including COVID-19. Consequently, the comprehensive finding of the current review shows a possible significant impact of vitamin D supplement as a hope in preventing, treating, and/or improving the progression of certain infections, specifically during the worldwide attempts to fight against the COVID-19 pandemic and minimize the severity of health complications encountered accordingly. In addition, avoiding a status of vitamin D deficiency to obtain its positive effects on the immune system and its protective mechanism during infections will be a general benefit overall.