Vitamin D and cancer – epidemiological association with colon and breast

Vitamin D and Cancer: An overview on Epidemiological studies

Advances in Experimental Medicine and Biology 810:17-32 · September 2014

José Manuel Ordóñez Mena1,2 and Hermann Brenner1,3

1 Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.E-Mail: 2 jose.ordonezmena@dkfz.de ; 3 hermann.brenner@dkfz.de

In recent years, a rapidly increasing number of studies have investigated the relationship of vitamin D with total cancer and site-specific cancer obtaining diverse findings. In this chapter we provide an overview of epidemiological studies of vitamin D intake, 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D serum levels and vitamin D associated polymorphisms in relation to total and site-specific cancer risk. Overall, epidemiological evidence for total cancer is inconclusive.

However, a large number of studies support a relationship of vitamin D with colorectal cancer and to a lesser extent with breast cancer. Findings are inconsistent for other cancers including all other gastrointestinal cancers and prostate cancer.

Different vitamin D associated polymorphisms were found to be significantly associated to colorectal, breast and prostate cancer risk.

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Overview Cancer-Colon and vitamin D

Overview Breast Cancer and Vitamin D contains the following summary and sections

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Cancer category starts with the following

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