Vitamin D (10,000 IU) changes bacteria in the gut – RCT

The Effect of Various Doses of Oral Vitamin D3 Supplementation on Gut Microbiota in Healthy Adults: A Randomized, Double-blinded, Dose-response Study

Anticancer Research January 2020 vol. 40 no. 1 551-556

NIPITH CHAROENNGAM, ARASH SHIRVANI, TYLER A. KALAJIAN, ANJELI SONG and MICHAEL F. HOLICK⇑

Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, MA, U.S.A.

Correspondence to: Michael F. Holick, MD, Ph.D., 85 E Newton St., M-1013, Boston, MA 02118, U.S.A. Tel: +1 6173586139, e-mail: mfholick@bu.edu

* Poor absorption of Vitamin D is strongly related to type of gut bacteria – Dec 2020 * Gut microbiome altered by many nutrients – such as Vitamin D – Jan 2020 * Strong interactions between Vitamin D and the gut microbiota via Butyrate and VDR – Dec 2019 * Vitamin D, Gut Microbiota, and Chemo-radiation interactions – Dec 2019 * Gut microbiome massively changed by weekly vitamin D – July 2015 * Resveratrol, Metabolic Syndrome, and Gut Microbiota – Nov 2018 * Gut and airway bionome are affected by Vitamin D and Vitamin D Receptor – Nov 2018 * Vitamin D Receptor in gut can be activated by lithocholic acid produced by gut bacteria * Prediabetic have very different gut bacteria – March 2015 * Exploring gut microbes in Human health and disease: pushing the envelope - Aug 2014 * Vitamin D, immunity and microbiome – Dec 2014 * Gut microbiome massively changed by weekly vitamin D – July 2015 *

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% change in Gut bacteria

Background/Aim: To investigate the effects of vitamin D3 supplementation on gut microbiota.

Patients and Methods: Twenty adults with vitamin D insufficiency/deficiency [25(OH)D <30 ng/ml] were enrolled and given 600, 4,000 or 10,000 IUs/day of oral vitamin D3. Stool samples were collected at baseline and 8 weeks for identifying gut microbiota using 16S rRNA gene amplification and sequencing.

Results: Baseline serum 25(OH)D was associated with increased relative abundance of Akkermansia and decreased relative abundance of Porphyromonas (p<0.05). After the intervention, we observed a dose-dependent increase in relative abundance of Bacteroides with a significant difference between the 600 IUs and the 10,000 IUs groups (p=0.027), and Parabacteroides with a significant difference between the 600 IUs and the 4,000 IUs groups (p=0.039).

Conclusion: Increased serum 25(OH)D was associated with increased beneficial bacteria and decreased pathogenic bacteria. A dose-dependent increase in bacteria associated with decreased inflammatory bowel disease activity was observed after vitamin D3 supplementation.