Very low birth weight infants were OK with 600 IU of vitamin D plus Calcium and Phosphorus

Created May 2018

Functional indicators of vitamin D adequacy for very low birth weight infants

Journal of Perinatology (2018), doi:10.1038/s41372-018-0098-7

Sarah N. Taylor, Amy Wahlquist, Carol L. Wagner, Viswanathan Ramakrishnan,

Myla Ebeling & Bruce W. Hollis

Most studies have found that more than 600 IU is needed, even for normal births Various studies also adjust the dose with infant weight * Search VitaminDWiki for "VERY LOW BIRTH WEIGHT" 335 items as of May 2018 * Many preemies need at least 800 IU of vitamin D – RCT May 2013 * 1600 IU was the conclusion of three JAMA studies * Preemies need 1,000 IU of vitamin D – RCT Sept 2017 * Premature infants (30 weeks) who got 800-1000 IU of vitamin D were much healthier – March 2017 Infant-Child category starts with {include} {include}

Free PDF is online at Sci-Hub

Objective: To identify the vitamin D status to optimize calcium and bone health in preterm infants.

Study design

Very low birth weight infants had measurement of 25-hydroxyvitamin D status and markers of calcium and bone health from birth to term age. Piecewise linear regression modeling was performed to identify a 25-hydroxyvitamin D threshold associated with stable parathyroid hormone concentration and bone mineralization.

Results

In a cohort of 89 infants at term age, femur BMC and density increased linearly with 25-hydroxyvitamin D status until reaching a threshold of 48 ng/mL and 46 ng/mL , respectively. Parathyroid hormone status decreased as vitamin D status increased until reaching a plateau at 25-hydroxyvitamin D of 42 ng/mL.

Conclusion

Preterm infant vitamin D status was significantly associated with PTH status and femur mineralization with suggestion that achieving a specific 25-hydroxyvitamin concentration is associated with optimal calcium homeostasis and femur bone mineralization.

From the PDF

The median (interquartile range) intake through the study were

  • vitamin D 609 (519,678) IU/day,

  • calcium 182 (141, 244) mg/kg/day

  • phosphorus 122 (85, 165) mg/kg/day

Tags: Infant-Child