Ulcerative Colitis – half have poor level of Vitamin D Receptor vs only one in ten normally

Vitamin D Receptor Level in Biopsy Specimen of Patients with Ulcerative Colitis: Results from a Center in Western Anatolia

Journal of the National Medical Association, DOI: http://dx.doi.org/10.1016/j.jnma.2017.06.003

Patients with negative Vitamin D Receptor levels UC 56%,    controls 10% 1. See also VitaminDWiki * Ulcerative Colitis significantly reduced by 480,000 IU loading dose of nano Vitamin D – RCT July 2019 * Ulcerative colitis treated by injection of 300,000 IU of vitamin D – RCT July 2016 * Ulcerative colitis associated with both low Vitamin D and poor Vitamin D Receptors – Oct 2016 * Ulcerative Colitis relapse 25 percent more likely if vitamin D level is lower than 35 ng – June 2016 * Perhaps because so many with UC have poor VDR which limits how much vitamin D gets to the cells * * Vitamin D Receptor category listing has items along with related searches** Overview Gut and vitamin D contains the following summary {include} Gut category listing contains the following {include} --- 23% of UC had poor VDR vs 7.7 % of controls - March 2019 Adv Clin Exp Med. 2019 Mar 28. doi: 10.17219/acem/97376 📄 Download the PDF from VitaminDWiki Types of UC

📄 Download the PDF from VitaminDWiki

Adil Coskun, M.D. M.D. Adil Coskun, M.D. Adil Coskun, Irfan Yavasoglu, M.D., Ibrahim Meteoglu, M.D., Mustafa Unubol, M.D., Burak Yasar, M.D., Serkan Borazan, M.D., Imran Kurt Omurlu, M.D., Vahit Yukselen, M.D., M. Hadi Yasa, M.D.

Background

Ulcerative colitis (UC) is a chronic, inflammatory bowel diseases characterized by uncontrolled inflammatory condition of the colon and rectal mucosa marked by recurrent periods of remission and exacerbation. Vitamin D receptor (VDR) is a member of the steroid receptor family that mediates the effects of vitamin D by regulating transcription of multiple cellular genes. We aimed to evaluate vitamin d receptor level in biopsy specimen of patients with UC in this study.

Methods

VDR levels were retrospectively studied in colon biopsy specimens of UC patients. The Spearman's rho correlation analysis, The Kolmogorov–Smirnov, Mann Whitney U, and chi-square tests were used for statistical analysis. The p values below 0.05 were considered statistically significant.

Results

Study included 112 UC patients (65 male and 47 female) and 30 controls (19 female and 11 male) who had normal results in biopsy examinations carried out due to various reasons. VDR levels of UC patients were statistically lower than control subjects, and was not associated with duration of the disease and place of involvement.

Conclusions

VDR is an important receptor in the pathogenesis of UC, and optimizing vitamin D levels could have a therapeutic role in UC.