Ulcerative colitis associated with both low Vitamin D and poor Vitamin D Receptors

Created November 2016

The association between vitamin D receptor polymorphisms and serum 25-hydroxyvitamin D levels with ulcerative colitis in Chinese Han population.

Clin Res Hepatol Gastroenterol. 2016 Oct 19. pii: S2210-7401(16)30131-0. doi: 10.1016/j.clinre.2016.09.001. [Epub ahead of print]

Zheng SZ1, Zhang DG1, Wu H1, Jiang LJ2, Jin J2, Lin XQ3, Ding R4, Jiang Y5.

* Ulcerative Colitis relapse 25 percent more likely if vitamin D level is lower than 35 ng – June 2016 * IBD (Colitis, Crohn’s) was active 6X more often if low vitamin D – June 2015 * Crohn's disease associated with 7.6X deactivation of Vitamin D receptor – July 2015 Vitamin D Receptor category has the following {include} An item from the table: If poor Vitamin D Receptor | | | | --- | --- | | Risk increase | Health Problem | | 7.6 | Crohn's disease |

1Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

2Department of Gastroenterology, the Wenzhou Central Hospital, Wenzhou, China.

3Department of Gastroenterology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

4Department of Gastroenterology, Wenzhou Renmin Hospital, Wenzhou, China.

5Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. wzjiangyi@yeah.net.

There is now growing evidence suggesting that Vitamin D is playing a critical role in modulating the innate and adaptive immune responses. Several polymorphisms have been identified in the vitamin D receptor (VDR) gene but their association with ulcerative colitis (UC) susceptibility remained controversy. In the current study, we examined the association between VDR polymorphisms and serum level of 25-hydroxyvitamin D [25(OH)D] with UC in Chinese Han population. Polymorphisms of FokI (rs2228570)/BsmI (rs1544410)/ApaI (rs7975232)/TaqI (rs731236) in the VDR gene were assessed in a case-control study comprising 404 UC patients and 612 controls. Moreover, 25(OH)D levels were measured by electro-chemiluminescence immunoassay in 75 UC patients and 120 controls. Our results suggested that BsmI polymorphism frequency was significantly lower in UC patients (P=0.028), and the frequency of AAC haplotype formed by BsmI, ApaI and TaqI was also significantly lower in UC patients (P=0.012).

Moreover, FokI polymorphism was more frequently observed in patients with mild and moderate UC as compared to those with severe UC (P=0.001, P<0.001, respectively). Average 25(OH)D level was lower in UC patients than in controls (19.3±6.8 vs. 21.8±7.3ng/mL, P=0.017), and was significantly correlated with hemoglobin (β=0.49, P<0.001), C-reactive protein (β=-0.36, P<0.001), severity of UC (β=-0.21, P=0.025) and FokI polymorphism (β=-0.20, P=0.031) in UC patients.

Interestingly, there was a significant correlation between FokI polymorphism and vitamin D deficiency (<20ng/mL) in UC patients (P=0.006).

Together, these results supported that VDR polymorphisms and 25(OH)D level were significantly correlated with UC risk and severity in Chinese Han population.

PMID: 27771345 DOI: 10.1016/j.clinre.2016.09.001

Tags: Gut Vit D Receptor