Type 1 Diabetes (Autoimmune) and Vitamin D, Vitamin D Receptor and Cathelicidin

Created December 2020

The roles of vitamin D and cathelicidin on type 1 diabetes susceptibility

Review Endocr Connect, 2020 Dec 1;EC-20-0484.R1. doi: 10.1530/EC-20-0484

Cecília Cristelo 1, Alexandra Machado 2, Bruno Sarmento 3, Francisco Miguel Gama 4

articles are in both Diabetes and infant-Child categories (proxie for T1 Diabetes) Items in categoriesInfant-Child & Diabetes & Meta-analysis: {category} Overview Diabetes and vitamin D contains the following {include} Diabetic Epidemic {include} 162 pages in VitaminDWiki have cathelicidin as of Dec 2020 Autoimmune category starts with {include} Items in both categories Autoimmune and Diabetes are listed here: {category} --- 1. See also web * Chapter thirteen - Vitamin D, Vitamin D Receptor, and Cathelicidin in the Treatment of Tuberculosis - 2011 https://doi.org/10.1016/B978-0-12-386960-9.00013-7 * Effect of cholecalciferol supplementation on vitamin D status and cathelicidin levels in sepsis: A randomized, placebo-controlled trial - Sept 2015 FREE PDF * Autoimmune thyroid disease and type 1 diabetes mellitus: same pathogenesis; new perspective? - Sept 2020 FREE PDF

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Type 1 diabetes has increasingly greater incidence and prevalence with no cure available. Vitamin D supplementation is well documented to reduce the risk of developing type 1 diabetes. Being involved in the modulation of cathelicidin expression, the question whether cathelicidin may be one of the underlying cause arises. Cathelicidin has been implicated in both the development and the protection against type 1 diabetes by mediating the interplay between the gut microbiome, the immune system and β cell function. While its potential on type 1 diabetes treatment seems high, the understanding of its effects is still limited. This review aims to contribute to a more comprehensive understanding of the potential of vitamin D and cathelicidin as adjuvants in type 1 diabetes therapy.

Tags: Diabetes Infant-Child Vit D Receptor