Type 1 diabetes 1.6 times more likely if a Vitamin D Receptor problem
:: There are two studies on the page ::
Association of VDR polymorphisms and type 1 diabetes susceptibility in children: a meta-analysis.
Endocr Connect. 2017 Feb 23. pii: EC-16-0110. doi: 10.1530/EC-16-0110. [Epub ahead of print]
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Sahin O1, Gökşen D2, Ozpinar A3, Serdar M4, Onay H5.
1O Sahin, Pediatrics, Acibadem Universitesi Tip Fakultesi, Istanbul, Turkey ozlemnaciyeatansahin@yahoo.com.
2D Gökşen, Department of Pediatric Endocrinology,, Ege University , Izmir, Turkey.
3A Ozpinar, Biochemistry, Acibadem Universitesi Tip Fakultesi, Istanbul, Turkey.
4M Serdar, Biochemistry, Acibadem Universitesi Tip Fakultesi, Istanbul, Turkey.
5H Onay, Department of Medical Genetics, Ege University Faculty of Medicine, Department of Medical Genetics, Izmir, 35100, Turkey.
OBJECTIVE:
There are studies evluating FokI, BsmI, ApaI and TaqI polymorphisms of the vitamin D receptor gene and susceptibility to DM1 (type 1 diabetes mellitus) with controversial results. This present study aims to investigate the association between FokI, ApaI, TaqI and BsmI polymorphisms of vitamin D receptor (VDR) gene and DM1 in children.
METHODS:
A literature search was performed using Medline, EMBASE, Cochrane and Pubmed. Studies were included in the study if at least one of FokI, ApaI, TaqI and BsmI polymorphisms was determined and outcome was DM1 at pediatric age. Data were pooled in a random effects logistic regression model and reported with 95% confidence intervals (95% CI).
RESULTS:
A total of 9 studies comprising 1053 patients and 1017 controls met the study inclusion criteria. The pooled odds ratios of the FokI, ApaI, TaqI and BsmI polymorphisms were combined and calculated. Forest plots and funnel plots of the odds ratio value distributions were drawn. Our meta-analysis has demonstrated statistically significant associations between DM1 and VDR genotypes, BsmIBB(P < 0.05), BsmIBb, (P < 0.05), BsmIbb(P < 0.05), TaqITT( P< 0.05) and TaqItt (P < 0.05) in children.
CONCLUSION:
The results indicated that BsmIBB, BsmIBb and TaqItt polymorphisms were associated with an increased risk of DM1, while BsmIbb and TaqITT had protective effect for DM1 in children.
T1 Diabetes and poor Vitamin D Receptor - Dec 2017
CLINICAL AND GENETIC VARIATION IN ASSOCIATION BETWEEN TYPE I DIABETES AND VITAMIN D DEFICIENCY