Time-release form of active vitamin D granted a patent for chronic kidney disease

OPKO Granted Patent from US Patent & Trademark Office for RAYALDEE

• Treat secondary hyperparathyroidism in patients with stage 3 or 4 chronic kidney disease (CKD) and vitamin D insufficiency.

• US Pat. No. 8,778,373

Notes by VitaminDWiki

1. Standard vitamin D is not available to much of the body when the kidney is not working

2. Standard active vitamin D has a very short half life, so time release form should be an excellent improvement - see other options below

See also VitaminDWiki

• Calcitriol category listing has items along with related searches

• Vitamin D3 vs serum D3 (Calcitriol, HyD) – Jan 2012

• Vitamin D3 becomes Calcidiol which becomes Calcitriol

• Nano-encapsulated of Vitamin D3, Calcidiol, calcitriol look promising, esp time release – Dec 2012 7 day!!

• Overview Kidney and vitamin D

• Getting Vitamin D into your blood and cells

• Modified release active Vitamin D (calcifediol ) for those with poor Kidney function (USD 10,000 per year) – April 2015

See also web

• Modified-Release Calcifediol Corrects Vitamin D Deficiency, Secondary Hyperparathyroidism in Chronic Kidney Disease Nov 2014
  • They found Modified-Release Calcifediol did much better than a placebo. Apparently did not test it against Vitamin D
• Modified-release oral calcifediol corrects vitamin D insufficiency with minimal CYP24A1 upregulation Nov 2014
  • 📄 Download the PDF from VitaminDWiki.
  • One of many charts in the PDF