Those with TB were 3.2 X more likely to have low vitamin D – 13th meta-analysis

Association of Vitamin D Deficiency With Pulmonary Tuberculosis: A Systematic Review and Meta-Analysis

Cureus 13(9): e17883. doi:10.7759/cureus.17883

Sunam Kafle, Anjan Kumar Basnet, Kumar Karki, Manusha Thapa Magar, Shumneva Shrestha, Randhir S. Yadav

Pulmonary tuberculosis, caused by Mycobacterium tuberculosis, is a significant public health issue, especially in developing countries, affecting millions of people every year. Despite the development of many antitubercular antibiotics and increased awareness of preventive methods, it is still a major cause of mortality worldwide. Vitamin D, a micronutrient known to have a major role in bone and calcium metabolism, has also shown its immunomodulatory effects to suppress mycobacterial growth. We conducted a systematic review and meta-analysis of the available evidence to explore the association between vitamin D levels and tuberculosis. We performed a systematic search for articles from inception to May 2021 in multiple databases.

We included 26 studies in our qualitative synthesis and 12 studies in meta-analysis or quantitative synthesis. In our meta-analysis, we used a random-effect model to calculate the odds ratio (OR) of vitamin D deficiency in tuberculosis patients compared to the healthy controls. On pooled analysis, we found that the odds of the participants having vitamin D deficiency was 3.23 times more in tuberculosis patients compared to the healthy group (OR=3.23, CI = 1.91-5.45, p<0.0001). Thus, we concluded that there is an association between low levels of vitamin D and tuberculosis infections. We suggest conducting long-term prospective cohort studies in tuberculosis endemic countries to better understand the causal relationship between vitamin D deficiency and tuberculosis.

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Overview Tuberculosis and Vitamin D has the following summary

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A few vitamin D and TB in VitaminDWiki

• Tuberculosis recovery speeded up by single 450,000 IU dose of vitamin D – RCT Jan 2017

• Tuberculosis -100 percent cure rate with 10,000 IU of vitamin D daily – RCT 2006

• Every TB patient benefited from 2 doses of 600,000 IU of vitamin D – RCT Jan 2013

• TB arrested by cod-liver oil (containing vitamin D) in 1848 3X better than other treatments at the time

TB Meta-analysis

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A Poor Vitamin D Receptor prevents Vitamin D in blood from getting to the cells

• Vitamin D Receptor is associated in over 40 autoimmune studies

  The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

Vitamin D Receptor activation can be increased by:

(Resveratrol)),  Omega-3,  Magnesium,  Zinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc

TB and Vitamin D Receptor:

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