Parkinson's disease may be treated with Thiamine
Report by Claude AI Deep Research Opus 4.7 April 2026
Thiamine for Parkinson's Disease_ Promising Signals, Weak Evidence, No RCT Yet.pdf
High-dose thiamine (HDT) is the only treatment proven to reverse Parkinson’s disease
"Mainstream doctors ignore it, even though about 70% of patients obtain nearly complete relief of their symptoms for years."
• Italian neurologist Antonio Costantini developed high-dose thiamine therapy for Parkinson’s disease in 2011 and treated more than 2,500 patients with reported improvements of 50 to 90 percent on motor and non-motor symptoms.
• Oral protocol: 2 to 3 grams per day of thiamine hydrochloride, split before and after lunch, water only, no acidic carriers.
• Oral equivalence with intramuscular or subcutaneous: 2 grams oral daily equals 100 mg IM or SQ weekly; 3 grams oral equals 75 mg twice weekly; 4 grams oral equals 100 mg twice weekly.
• Vitamin B6 sabotages thiamine treatment in patients on L-dopa because B6 activates peripheral decarboxylase and blocks L-dopa from reaching the brain, so stop supplementing it.
• Costantini died of COVID-19 in May 2020. The B1 Parkinson’s Foundation, supported by Daphne Bryan PhD and others, now continues the work and is planning a randomized controlled trial.
• Injectable thiamine in the US now requires a prescription. A 503A compounding pharmacy is the cleanest sourcing route. A sublingual thiamine mononitrate formulation offers a third option backed by anecdote rather than trial data.
Thiamine - Vitamin B1
They're two names for the same water-soluble vitamin. It's essential for carbohydrate metabolism and nerve function, and deficiency causes beriberi and Wernicke-Korsakoff syndrome.
Inhaling Thiamine thru the nose might get it directly into the brain
Parkenson's in VitaminDWiki
- Parkinson’s Disease and Vitamin D – review of 52 studies
- Vitamin D and neurodegenerative diseases
Parkinson's doubled in 26 years (1 in 3 people now how a neurological condition) – 2024
Vitamin D associated with Parkinson’s Disease in 55 studies, more studies needed
- Cognitive impairment 5 percent less likely for each ng more of Vitamin D (Parkinson’s)
- Parkinson’s patients 50X less likely to get even a little sun– meta-analysis
- Parkinson’s patients – 41 percent now supplement with Vitamin D
Parkinson's and poor Vitamin D Receptor in VitaminDWiki
- Parkinson’s risk increased 2 to 7 times depending on Vitamin D Receptor
- 2X more Parkinson's disease if modified vitamin D receptor genes – meta-analysis
- Parkinson’s Disease might be fought by Vitamin D and the activation of the Vitamin D Receptor
Glutathione and Parkinson's in VitaminDWiki
Note: Glutathione activates the Vitamin D Receptor