The role of vitamin D in gastrointestinal inflammation (behind a 89 dollar paywall)

Expert Review of Gastroenterology & Hepatology (doi:10.1586/17474124.2014.925796)

Simon Ghaly and Ian Lawrance Ian.Lawrance@uwa.edu.au

Centre for Inflammatory Bowel Diseases, Fremantle Hospital and School of Medicine and Pharmacology, University of Western Australia, Level 5, T Block, Alma St, Fremanlte, Western Australia 6159, Australia

The emerging role of vitamin D as a regulator of both innate and adaptive immune responses has encouraged the investigation of its role in the pathogenesis of a variety of autoimmune conditions including the

• inflammatory bowel diseases (IBD),

• Crohn’s disease and

• ulcerative colitis.

Animal models consistently demonstrate that vitamin D significantly impacts on the modulation of astrointestinal inflammation, while epidemiological and observational data show an inverse relationship between vitamin D status and the onset/progression of Crohn’s disease as well as the development of colorectal cancer. As vitamin D supplementation is readily available, at low cost, it is a very attractive potential therapeutic option . The biological plausibility for a role for vitamin D in inflammation modulation, the potential genetic links associated with vitamin D metabolism and the clinical aspects for it in IBD will be discussed.

The most expensive paywall I have seen so far

See also VitaminDWiki (for free)

• Overview Gut and vitamin D

• Gut category listing with associated searches

  The TOP articles in Gut and Vitamin D are listed here:

{category}