The more preterm the birth, the lower the vitamin D level (both mothers and infants)

Vitamin D status of early preterm infants and the effects of vitamin D intake during hospital stay

Arch Dis Child Fetal Neonatal Ed 2014;99:F166-F168 doi:10.1136/archdischild-2013-303999

Nagendra Monangi 1, Jonathan L Slaughter 2,3, Adekunle Dawodu 4, Carrie Smith 5, Henry T Akinbi 1

1Neonatal Perinatal Medicine, Perinatal Institute, Cincinnati Children's Hospital Medical Center/University of Cincinnati, Cincinnati, Ohio, USA

2Center for Perinatal Research and Ohio Perinatal Research Network, Nationwide Children's Hospital, Columbus, Ohio, USA

3Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA

4Global Health Center, Cincinnati Children's Hospital Medical Center/University of Cincinnati, Cincinnati, Ohio, USA

5University of Cincinnati Medical Center, Cincinnati, Ohio, USA

Correspondence to: Dr Henry T Akinbi, Division of Neonatology and Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229-3039, USA; henry.akinbi@cchmc.org

Abstract

Objectives To evaluate vitamin D (vitD) status in early preterm infants (EPTIs) at birth and during birth hospitalisation on current vitD intake.

Design/methods Serum 25-hydroxyvitamin-D [25(OH)D] concentrations, vitD intake and risk factors for low vitD status were assessed in 120 infants born at ≤32 weeks gestation.

Results Mean (SD) serum 25(OH)D at birth was 46.2 (14.0) nmol/L with lower concentrations in infants born <28 weeks than at 28–32 weeks gestation, p=0.02. Serum 25(OH)D was <50 nmol/L in 63% of mothers, 64% of infants at birth and 35% of infants at discharge. Mean daily vitD intake was 289±96 IU at 4 weeks of age and 60% achieved 400 IU/day intake at discharge.

Conclusions Serum 25(OH)D <50 nmol/L was widespread in parturient women and in EPTIs at birth and at discharge. Optimising maternal vitD status during pregnancy and improving postnatal vitD intake may enhance infant vitD status during hospitalisation.

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See also VitaminDWiki

• Pre-term 482 items as of Feb 2014

• Vitamin D Webinar - cost of pre-term birth etc- Baggerly Nov 2013

• WHO still says mistakenly says NO vitamin D during pregnancy, and only 200 IU after

• Pre-term birth 3X more likely and C-section 4X if less than 20 ng of vitamin D – May 2012

• Chance of preterm birth is strongly associated with low vitamin D – Feb 2015

• Overview Pregnancy and vitamin D has the following summary

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