Sudden Cardiac Arrest 10.8 X more likely if severe vitamin D deficiency

Vitamin D deficiency as a risk factor for sudden cardiac arrest: A multicenter case-control study

Nutr Metab Cardiovasc Dis . 2024 May 10:S0939-4753(24)00175-3. Doi: 10.1016/j.numecd.2024.05.007 PDF behind paywall

Mi Jin Lee 1, Haewon Jung 2, Sang Do Shin 3, Young Sun Ro 3, Jeong Ho Park 3, Young-Il Roh 4, Woo Jin Jung 4, Ju Ok Park 5, Seung Min Park 6, Sang-Chul Kim 7, Jonghwan Shin 8, Yong Won Kim 9, Ju-Young Hong 10, Hyun Ho Ryu 11, Su Jin Kim 12, Jong-Hak Park 12, Won Young Kim 13, Gun Tak Lee 14, Sung Bum Oh 15; CATURES II Consortium

Background and aims: Vitamin D is known to influence the risk of cardiovascular disease, which is a recognized risk factor for sudden cardiac arrest (SCA). However, the relationship between vitamin D and SCA is not well understood. Therefore, this study aims to investigate the association between vitamin D and SCA in out-of-hospital cardiac arrest (OHCA) patients compared to healthy controls.

Methods and results: Using the Phase II Cardiac Arrest Pursuit Trial with Unique Registration and Epidemiologic Surveillance (CAPTURES II) registry, a 1:1 propensity score-matched case-control study was conducted between 2017 and 2020. Serum 25-hydroxyvitamin D (vitamin D) levels in patients with OHCA (454 cases) and healthy controls (454 cases) were compared after matching for age, sex, cardiovascular risk factors, and lifestyle behaviors. The mean vitamin D levels were 14.5 ± 7.6 and 21.3 ± 8.3 ng/mL among SCA cases and controls , respectively. Logistic regression analysis was used adjusting for cardiovascular risk factors, lifestyle behaviors, corrected serum calcium levels, and estimated glomerular filtration rate (eGRF). The adjusted odds ratio (aOR) for vitamin D was 0.89 (95% confidence interval [CI] 0.87-0.91). The dose-response relationship demonstrated that vitamin D deficiency was associated with SCA incidence (severe deficiency, aOR 10.87 , 95% CI 4.82-24.54; moderate deficiency, aOR 2.24, 95% CI 1.20-4.20).

Conclusion: Vitamin D deficiency was independently and strongly associated with an increased risk of SCA, irrespective of cardiovascular and lifestyle factors, corrected calcium levels, and eGFR.

21+ VitaminDWiki pages have SUDDEN CARDIAC or CARDIOVASCULAR DEATH in the title

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