Some Rickets is due to poor genes - Vitamin D needed lifelong

Diagnosis and Management of Vitamin D Dependent Rickets

Front. Pediatr., 12 June 2020 | https://doi.org/10.3389/fped.2020.00315

Michael A. Levine*

Center for Bone Health and Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States

Rickets almost eradicated in counties giving free Vitamin D, perhaps the world can learn – Dec 2019 Overview of Rickets and vitamin D contains the following summary {include} Genetics has the following chart The items in both Rickets and Genetics are listed here: {category} The items in both Rickets and Vitamin D Receptor are listed here: {category}

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Note by VitaminDWiki - Vitamin D values seem to be about 40X too large - perhaps should be IU, not micrograms

The term “vitamin D dependent rickets” describes a group of genetic disorders that are characterized by early-onset rickets due to the inability to maintain adequate concentrations of active forms of vitamin D or a failure to respond fully to activated vitamin D. Although the term is now admittedly a pathophysiological misnomer, there remains clinical relevance for its continued use, as patients have a lifelong “dependency” on administration of specialized regimens of vitamin D replacement. This review provides an update on the molecular bases for the three forms of vitamin D dependent rickets, and summarizes current protocols for management of affected subjects.