Risk of Autoimmune Uveitis (an outer eye inflammation) decreases 6% for each 1 ng higher level of vitamin D – Coimbra

Created July 2024

Serum Vitamin D Levels as Biomarkers in Patients with Autoimmune Uveitis and their Possible Correlation with Disease Activity

Ocul Immunol Inflamm. 2024 Jul;32(5):628-635. doi: 10.1080/09273948.2023.2184699 PDF behind paywall

Karine Koller 1, Kimble Matos Teixeira Fonseca 1, Kelsy N Areco 2, Yuslay Fernández-Zamora 1, Luci Meire Pereira Silva 1, Ricardo Pedro Casaroli-Marano 1 3, Cicero Galli Coimbra 4, Cristina Muccioli 1

This study investigated the correlation between serum vitamin D levels and intraocular inflammation in patients with autoimmune uveitis (AIU). We evaluated 67 patients with active and inactive AIU and measured their serum 25-hydroxyvitamin D [25(OH)D] concentration, sun exposure habits, number of relapses, and complications. Of the patients evaluated, 85% had significantly lower vitamin D levels, and patients with active uveitis had lower 25(OH)D levels than those with inactive uveitis.

The odds of developing active uveitis decreased by 6% with each 1-unit increase in 25(OH)D. Patients with recurrent active AIU had significantly lower 25(OH)D serum levels than inactive forms, indicating that low vitamin D levels may alter the clinical course of intraocular inflammation in AIU. Additionally, the study found that a higher mean BMI increased the chances of an individual having active uveitis by 14%. These results suggest that serum vitamin D concentration could be a prognostic clinical biomarker in AIU.

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